HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 15 member 1

External ID: CHEMBL863210

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 12
First Page: 3636
Last Page: 3644
DOI: 10.1021/jm0511029

Target ChEMBL ID: CHEMBL4605
ChEMBL Target Name: Oligopeptide transporter small intestine isoform
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
80	EC50	=	80000	nM
	EC50				Not Determined
50	EC50	=	50000	nM
	EC50				Not Determined
	EC50				Not Determined
	EC50				Not Determined
	EC50				Not Determined
130	EC50	=	130000	nM		Outside typical range
250	EC50	=	250000	nM		Outside typical range
140	EC50	=	140000	nM		Outside typical range
330	EC50	=	330000	nM		Outside typical range
580	EC50	=	580000	nM		Outside typical range
170	EC50	=	170000	nM		Outside typical range
480	EC50	=	480000	nM		Outside typical range
80	EC50	=	80000	nM
80	EC50	=	80000	nM
70	EC50	=	70000	nM
130	EC50	=	130000	nM		Outside typical range
280	EC50	=	280000	nM		Outside typical range
80	EC50	=	80000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 15 member 1

External ID: CHEMBL863211

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 12
First Page: 3636
Last Page: 3644
DOI: 10.1021/jm0511029

Target ChEMBL ID: CHEMBL4605
ChEMBL Target Name: Oligopeptide transporter small intestine isoform
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
max activation	=	108	%
max activation	=	120	%
max activation	=	99	%
max activation	=	125	%
max activation				Not Active
max activation	=	58	%
max activation				Not Active
max activation				Not Active
max activation				Not Active
max activation				Not Active
max activation	=	111	%
max activation	=	125	%
max activation	=	23	%
max activation	=	42	%
max activation	=	109	%
max activation	=	103	%
max activation	=	112	%
max activation	=	135	%
max activation	=	111	%
max activation	=	122	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL634473

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 6
First Page: 853
Last Page: 863
DOI: 10.1021/jm9704311

Standard Type	Standard Relation	Standard Value
Log K1	=	-1.53
Log K1	=	-0.83
Log K1	=	-0.68
Log K1	=	-2.73
Log K1	=	-1.94
Log K1	=	-2.55
Log K1	=	-0.78

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632517

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 6
First Page: 853
Last Page: 863
DOI: 10.1021/jm9704311

Standard Type	Standard Relation	Standard Value
Log K-1	=	-1.75
Log K-1	=	-1.7
Log K-1	=	-2.5
Log K-1	=	-1.72
Log K-1	=	-1.74
Log K-1	=	-1.77
Log K-1	=	-1.57
Log K-1	=	-1.94

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dipeptidyl peptidase 4

External ID: CHEMBL857575

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 12
First Page: 1537
Last Page: 1540
DOI: 10.1016/s0960-894x(98)00259-5

Target ChEMBL ID: CHEMBL284
ChEMBL Target Name: Dipeptidyl peptidase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	4	%
Inhibition	=	10	%
Inhibition	=	2	%
Inhibition	=	15	%
Inhibition	=	0	%
Inhibition	=	3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 15 member 1

External ID: CHEMBL863213

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 12
First Page: 3636
Last Page: 3644
DOI: 10.1021/jm0511029

Target ChEMBL ID: CHEMBL4605
ChEMBL Target Name: Oligopeptide transporter small intestine isoform
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
250	IC50	=	250000	nM		Outside typical range
	IC50				Not Determined
90	IC50	=	90000	nM
80	IC50	=	80000	nM
250	IC50	=	250000	nM		Outside typical range
	IC50				Not Determined
7310	IC50	=	7310000	nM		Outside typical range
170	IC50	=	170000	nM		Outside typical range
620	IC50	=	620000	nM		Outside typical range
120	IC50	=	120000	nM		Outside typical range
520	IC50	=	520000	nM		Outside typical range
1070	IC50	=	1070000	nM		Outside typical range
70	IC50	=	70000	nM
820	IC50	=	820000	nM		Outside typical range
70	IC50	=	70000	nM
170	IC50	=	170000	nM		Outside typical range
210	IC50	=	210000	nM		Outside typical range
330	IC50	=	330000	nM		Outside typical range
340	IC50	=	340000	nM		Outside typical range
260	IC50	=	260000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL635141

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 6
First Page: 853
Last Page: 863
DOI: 10.1021/jm9704311

Standard Type	Standard Relation	Standard Value
LogD	=	1.03
LogD	=	1.43
LogD	=	0.57
LogD	=	1.54
LogD	=	-1.38
LogD	=	-0.52
LogD	=	-1.13
LogD	=	-1.02
LogD	=	1.4
LogD	=	0.86
LogD	=	0.86
LogD	=	0.07

19653-76-0 靶点实验数据