HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL676793

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 509
Last Page: 518
DOI: 10.1021/jm030182i

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.3	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	2	ug.mL-1
MIC	>	40	ug.mL-1
MIC	=	0.07	ug.mL-1
MIC	=	3.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fatty acid-binding protein, intestinal

External ID: CHEMBL684420

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 509
Last Page: 518
DOI: 10.1021/jm030182i

Target ChEMBL ID: CHEMBL4879
ChEMBL Target Name: Fatty acid binding protein intestinal
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1700	K1	=	1.7	mM
	K1	=	1.1	pM
0.5	K1	=	0.5	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fatty acid-binding protein, intestinal

External ID: CHEMBL684421

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 509
Last Page: 518
DOI: 10.1021/jm030182i

Target ChEMBL ID: CHEMBL4879
ChEMBL Target Name: Fatty acid binding protein intestinal
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	K2	=	30	uM
0.4	K2	=	0.4	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melatonin receptor type 1A

External ID: CHEMBL4390239

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 15
First Page: 3299
Last Page: 3306
DOI: 10.1016/j.bmc.2019.06.008

Target ChEMBL ID: CHEMBL1945
ChEMBL Target Name: Melatonin receptor 1A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	80.3	%
Activity	=	45.9	%
Activity	=	44.6	%
Activity	=	46.5	%
Activity	=	25.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL684423

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 3
First Page: 509
Last Page: 518
DOI: 10.1021/jm030182i

Standard Type	Activity Comment
pKa	Not Determined
pKa	Not Determined
pKa	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melatonin receptor type 1B

External ID: CHEMBL4390240

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 15
First Page: 3299
Last Page: 3306
DOI: 10.1016/j.bmc.2019.06.008

Target ChEMBL ID: CHEMBL1946
ChEMBL Target Name: Melatonin receptor 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	103	%
Activity	=	67.1	%
Activity	=	94.1	%
Activity	=	134.2	%
Activity	=	59.4	%

1965-09-9 靶点实验数据