HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL999157

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1998
Volume: 61
Issue: 7
First Page: 896
Last Page: 900
DOI: 10.1021/np980028c

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	5.95	ug ml-1
ED50	=	4.95	ug ml-1
ED50	=	7.64	ug ml-1
ED50	=	10.44	ug ml-1
ED50	=	63.54	ug ml-1
ED50	=	59.32	ug ml-1
ED50	=	58.09	ug ml-1
ED50	=	95.92	ug ml-1
ED50	=	70.98	ug ml-1
ED50	=	39.86	ug ml-1
ED50	=	0.015	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Erythrocyte

External ID: CHEMBL996356

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2004
Volume: 67
Issue: 4
First Page: 631
Last Page: 637
DOI: 10.1021/np034033e

Target ChEMBL ID: CHEMBL4296518
ChEMBL Target Name: Erythrocyte
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1017630

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2004
Volume: 67
Issue: 4
First Page: 631
Last Page: 637
DOI: 10.1021/np034033e

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
163.9	IC50	=	163900	nM	Outside typical range
104.5	IC50	=	104500	nM	Outside typical range
84.1	IC50	=	84100	nM
145.2	IC50	=	145200	nM	Outside typical range
93.3	IC50	=	93300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SW480

External ID: CHEMBL2388323

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1032
Last Page: 1038
DOI: 10.1021/np400010c

Target ChEMBL ID: CHEMBL612544
ChEMBL Target Name: SW480
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
19.3	IC50	=	19300	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Erythrocyte

External ID: CHEMBL995516

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2004
Volume: 67
Issue: 4
First Page: 631
Last Page: 637
DOI: 10.1021/np034033e

Target ChEMBL ID: CHEMBL4296518
ChEMBL Target Name: Erythrocyte
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HL-60

External ID: CHEMBL2388327

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1032
Last Page: 1038
DOI: 10.1021/np400010c

Target ChEMBL ID: CHEMBL383
ChEMBL Target Name: HL-60
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
11.77	IC50	=	11770	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SMMC-7721

External ID: CHEMBL2388326

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1032
Last Page: 1038
DOI: 10.1021/np400010c

Target ChEMBL ID: CHEMBL613831
ChEMBL Target Name: SMMC-7721
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
15.48	IC50	=	15480	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL2388325

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1032
Last Page: 1038
DOI: 10.1021/np400010c

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
16.58	IC50	=	16580	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL2388324

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 6
First Page: 1032
Last Page: 1038
DOI: 10.1021/np400010c

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
20.35	IC50	=	20350	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutrophil

External ID: CHEMBL4618039

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2020
Volume: 30
Issue: 10
First Page: 127127
Last Page: 127127
DOI: 10.1016/j.bmcl.2020.127127

Target ChEMBL ID: CHEMBL5314326
ChEMBL Target Name: Neutrophil
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95.2	%
Inhibition	=	78	%
Inhibition	=	50.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Erythrocyte

External ID: CHEMBL996346

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2004
Volume: 67
Issue: 4
First Page: 631
Last Page: 637
DOI: 10.1021/np034033e

Target ChEMBL ID: CHEMBL4296518
ChEMBL Target Name: Erythrocyte
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutrophil

External ID: CHEMBL4618041

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2020
Volume: 30
Issue: 10
First Page: 127127
Last Page: 127127
DOI: 10.1016/j.bmcl.2020.127127

Target ChEMBL ID: CHEMBL5314326
ChEMBL Target Name: Neutrophil
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	61.9	%
Inhibition	=	19.9	%
Inhibition	=	22.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-1080

External ID: CHEMBL999156

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1998
Volume: 61
Issue: 7
First Page: 896
Last Page: 900
DOI: 10.1021/np980028c

Target ChEMBL ID: CHEMBL614580
ChEMBL Target Name: HT-1080
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	2.91	ug ml-1
ED50	=	5.83	ug ml-1
ED50	=	2.3	ug ml-1
ED50	=	4.05	ug ml-1
ED50	=	72.91	ug ml-1
ED50	=	45.47	ug ml-1
ED50	=	57.4	ug ml-1
ED50	=	75.43	ug ml-1
ED50	=	26.97	ug ml-1
ED50	=	38.92	ug ml-1
ED50	=	0.034	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Erythrocyte

External ID: CHEMBL996352

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2004
Volume: 67
Issue: 4
First Page: 631
Last Page: 637
DOI: 10.1021/np034033e

Target ChEMBL ID: CHEMBL4296518
ChEMBL Target Name: Erythrocyte
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4618035

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2020
Volume: 30
Issue: 10
First Page: 127127
Last Page: 127127
DOI: 10.1016/j.bmcl.2020.127127

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50	=	14.5	ug.mL-1
IC50	=	2.8	ug.mL-1
IC50	=	15.1	ug.mL-1
IC50				Not Active
IC50	=	0.4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4618037

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2020
Volume: 30
Issue: 10
First Page: 127127
Last Page: 127127
DOI: 10.1016/j.bmcl.2020.127127

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50	=	0.004	ug.mL-1
IC50	=	0.8	ug.mL-1
IC50				Not Active
IC50	=	0.057	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL4618036

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2020
Volume: 30
Issue: 10
First Page: 127127
Last Page: 127127
DOI: 10.1016/j.bmcl.2020.127127

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
IC50	=	0.07	ug.mL-1
IC50	=	1.1	ug.mL-1
IC50				Not Active
IC50	=	0.6	ug.mL-1

1909-91-7 靶点实验数据