HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL940973

Protocol: N/A

Comment: Journal: Nature
Year: 2007
Volume: 445
Issue: 7127
First Page: 541
Last Page: 545
DOI: 10.1038/nature05544

Target ChEMBL ID: CHEMBL1075310
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL940166

Protocol: N/A

Comment: Journal: Nature
Year: 2007
Volume: 445
Issue: 7127
First Page: 541
Last Page: 545
DOI: 10.1038/nature05544

Target ChEMBL ID: CHEMBL1075310
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL1118242

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 14
First Page: 5085
Last Page: 5107
DOI: 10.1021/jm100062h

Target ChEMBL ID: CHEMBL6007
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.319	EC50	=	319	nM
10	EC50	=	10000	nM
125	EC50	=	125000	nM	Outside typical range
1.9	EC50	=	1900	nM
28.4	EC50	=	28400	nM
1580	EC50	=	1580000	nM	Outside typical range
5	EC50	=	5000	nM
18.4	EC50	=	18400	nM
5.6	EC50	=	5600	nM
41	EC50	=	41000	nM
19.7	EC50	=	19700	nM
6.6	EC50	=	6600	nM
16	EC50	=	16000	nM
24	EC50	=	24000	nM
15.1	EC50	=	15100	nM
22.4	EC50	=	22400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1

External ID: CHEMBL940160

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nature
Year: 2007
Volume: 445
Issue: 7127
First Page: 541
Last Page: 545
DOI: 10.1038/nature05544

Target ChEMBL ID: CHEMBL6007
ChEMBL Target Name: Transient receptor potential cation channel subfamily A member 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
19	EC50	=	19000	nM
	Activity				Not Active
33.5	EC50	=	33500	nM
	Activity				Not Active
1.58	EC50	=	1580	nM
134	EC50	=	134000	nM		Outside typical range
0.1	EC50	=	100	nM
5	EC50	=	5000	nM
18.4	EC50	=	18400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Botulinum neurotoxin type A

External ID: CHEMBL4670470

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 19.0
First Page: 11100
Last Page: 11120
DOI: 10.1021/acs.jmedchem.0c01006

Target ChEMBL ID: CHEMBL5192
ChEMBL Target Name: Botulinum neurotoxin type A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Ratio	=	65	/M/s
Ratio	=	440	/M/s

190852-41-6 靶点实验数据