HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G1/S-specific cyclin-D3

External ID: CHEMBL4768583

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 193
First Page: 112239
Last Page: 112239
DOI: 10.1016/j.ejmech.2020.112239

Target ChEMBL ID: CHEMBL3038472
ChEMBL Target Name: CDK4/Cyclin D3
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0027	IC50	=	2.7	nM
0.0103	IC50	=	10.3	nM
0.0045	IC50	=	4.5	nM
0.5923	IC50	=	592.3	nM
0.0022	IC50	=	2.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-87 MG

External ID: CHEMBL4768586

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 193
First Page: 112239
Last Page: 112239
DOI: 10.1016/j.ejmech.2020.112239

Target ChEMBL ID: CHEMBL614247
ChEMBL Target Name: U-87 MG
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.5851	IC50	=	585.1	nM
0.0846	IC50	=	84.6	nM
0.0648	IC50	=	64.8	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G1/S-specific cyclin-D3

External ID: CHEMBL4768584

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 193
First Page: 112239
Last Page: 112239
DOI: 10.1016/j.ejmech.2020.112239

Target ChEMBL ID: CHEMBL3038472
ChEMBL Target Name: CDK4/Cyclin D3
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0048	IC50	=	4.8	nM
0.009	IC50	=	9	nM
0.0043	IC50	=	4.3	nM
3.09	IC50	=	3090	nM
0.0025	IC50	=	2.5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：COLO 205

External ID: CHEMBL4768585

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 193
First Page: 112239
Last Page: 112239
DOI: 10.1016/j.ejmech.2020.112239

Target ChEMBL ID: CHEMBL614561
ChEMBL Target Name: COLO 205
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined
0.0564	IC50	=	56.4	nM
0.0734	IC50	=	73.4	nM
2.839	IC50	=	2839	nM

1908454-93-2 靶点实验数据