HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811158

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
FC	=	3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811040

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811039

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811410

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	25	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811026

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811025

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	77	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811024

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	2.7	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811023

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	2	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811030

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811029

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811028

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811027

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811034

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811033

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811032

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	28	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811031

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811038

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3811037

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDCK

External ID: CHEMBL3811009

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614068
ChEMBL Target Name: MDCK
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Papp	=	24	10'-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDCK

External ID: CHEMBL3811014

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614068
ChEMBL Target Name: MDCK
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	0.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811018

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	2.9	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811017

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	87	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3811016

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Standard Type	Standard Relation	Standard Value
BPR	=	0.62

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDCK

External ID: CHEMBL3811015

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614068
ChEMBL Target Name: MDCK
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	0.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811022

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	18	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasma

External ID: CHEMBL3811021

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL613652
ChEMBL Target Name: Plasma
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
PPB	=	98.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811020

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3811019

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	8.8	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811415

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811412

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811418

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811417

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
FC	=	2.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811416

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha

External ID: CHEMBL3811421

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL2808
ChEMBL Target Name: LXR-alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	49	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-beta

External ID: CHEMBL3811420

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL4093
ChEMBL Target Name: LXR-beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	103	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3811005

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Standard Type	Standard Relation	Standard Value	Standard Units
PPB	=	99.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca mulatta

External ID: CHEMBL3811603

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 3489
Last Page: 3498
DOI: 10.1021/acs.jmedchem.6b00176

Target ChEMBL ID: CHEMBL614875
ChEMBL Target Name: Rhesus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	25	%

1908434-16-1 靶点实验数据