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1890-99-9 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tyrosine-protein phosphatase non-receptor type 1
External ID: CHEMBL4035961
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=29%
Inhibition=43%
Inhibition=28%
Inhibition=55%
Inhibition=48%
Inhibition=18%
Inhibition=20%
Inhibition=75%
Inhibition=18%
Inhibition=98%
Inhibition=33%
Inhibition=15%
Inhibition=19%
Inhibition=79%
Inhibition=73%
Inhibition=47%
Inhibition=36%
Inhibition=46%
Inhibition=94%
Inhibition=52%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL4035959
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=14%
Inhibition=22%
Inhibition=0%
Inhibition=0%
Inhibition=6%
Inhibition=56%
Inhibition=9%
Inhibition=0%
Inhibition=3%
Inhibition=25%
Inhibition=3%
Inhibition=73%
Inhibition=11%
Inhibition=41%
Inhibition=0%
Inhibition=4%
Inhibition=19%
Inhibition=34%
Inhibition=3%
Inhibition=8%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:RAW264.7
External ID: CHEMBL4035957
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=13%
Inhibition=6%
Inhibition=0%
Inhibition=5%
Inhibition=14%
Inhibition=39%
Inhibition=1%
Inhibition=26%
Inhibition=58%
Inhibition=16%
Inhibition=0%
Inhibition=22%
Inhibition=0%
Inhibition=19%
Inhibition=0%
Inhibition=1%
Inhibition=0%
Inhibition=14%
Inhibition=0%
Inhibition=3%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Nuclear factor erythroid 2-related factor 2
External ID: CHEMBL4046717
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 20
First Page: 5522
Last Page: 5530
DOI: 10.1016/j.bmc.2017.08.018

Target ChEMBL ID: CHEMBL1075094
ChEMBL Target Name: Nuclear factor erythroid 2-related factor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard Value
FC=1.2
FC=1.23
FC=4.67
FC=4.07
FC=1.42
FC=4.09
FC=1.17
FC=1.87
FC=2.65
FC=1.08
FC=1.49
FC=2.17
FC=1.91
FC=2.28
FC=1.97
FC=1.41
FC=1.34
FC=1.91
FC=1.21
FC=1.12
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HepG2
External ID: CHEMBL4035954
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
GI=29%
GI=28%
GI=3%
GI=18%
GI=0%
GI=14%
GI=22%
GI=6%
GI=21%
GI=2%
GI=0%
GI=5%
GI=6%
GI=40%
GI=39%
GI=0%
GI=13%
GI=24%
GI=7%
GI=0%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:PANC-1
External ID: CHEMBL928450
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 1
First Page: 181
Last Page: 189
DOI: 10.1016/j.bmc.2007.10.004

Target ChEMBL ID: CHEMBL614139
ChEMBL Target Name: PANC-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
100CD100>100uM
100CD100>100uM
1CD100=1uM
100CD100>100uM
100CD100>100uM
100CD100>100uM
100CD100>100uM
100CD100>100uM
100CD100>100uM
100CD100>100uM
100CD100>100uM
50CD100=50uM
100CD100>100uM
100CD100>100uM
50CD100=50uM
25CD100=25uM
100CD100>100uM
100CD100>100uM
50CD100=50uM
12.5CD100=12.5uM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Polyphenol oxidase 4
External ID: CHEMBL4035963
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL6066154
ChEMBL Target Name: Mushroom tyrosinase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=2%
Inhibition=10%
Inhibition=9%
Inhibition=11%
Inhibition=12%
Inhibition=1%
Inhibition=5%
Inhibition=16%
Inhibition=2%
Inhibition=16%
Inhibition=10%
Inhibition=14%
Inhibition=15%
Inhibition=2%
Inhibition=14%
Inhibition=11%
Inhibition=2%
Inhibition=5%
Inhibition=3%
Inhibition=8%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:A549
External ID: CHEMBL995573
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 10
First Page: 5434
Last Page: 5440
DOI: 10.1016/j.bmc.2008.04.016

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
98.9IC50=98900nM
100IC50>100000nM
100IC50>100000nM
9.19IC50=9190nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
62.1IC50=62100nM
100IC50>100000nM
42.6IC50=42600nM
100IC50>100000nM
38IC50=38000nM
39.5IC50=39500nM
100IC50>100000nM
100IC50>100000nM
97.3IC50=97300nM
100IC50>100000nM
9.9IC50=9900nM
100IC50>100000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HeLa
External ID: CHEMBL995574
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 10
First Page: 5434
Last Page: 5440
DOI: 10.1016/j.bmc.2008.04.016

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
82.6IC50=82600nM
100IC50>100000nM
100IC50>100000nM
0.77IC50=770nM
92.5IC50=92500nM
100IC50>100000nM
100IC50>100000nM
84.3IC50=84300nM
67.9IC50=67900nM
100IC50>100000nM
36.1IC50=36100nM
100IC50>100000nM
39.3IC50=39300nM
23.4IC50=23400nM
100IC50>100000nM
100IC50>100000nM
47.1IC50=47100nM
61.2IC50=61200nM
24.2IC50=24200nM
100IC50>100000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL995571
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 10
First Page: 5434
Last Page: 5440
DOI: 10.1016/j.bmc.2008.04.016

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
80.5IC50=80500nM
100IC50>100000nM
100IC50>100000nM
5.78IC50=5780nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
64.9IC50=64900nM
56.3IC50=56300nM
100IC50>100000nM
44.8IC50=44800nM
100IC50>100000nM
72.6IC50=72600nM
42.4IC50=42400nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
47.5IC50=47500nM
30.4IC50=30400nM
100IC50>100000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL995572
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 10
First Page: 5434
Last Page: 5440
DOI: 10.1016/j.bmc.2008.04.016

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
84IC50=84000nM
100IC50>100000nM
100IC50>100000nM
2.59IC50=2590nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
69.1IC50=69100nM
100IC50>100000nM
34.4IC50=34400nM
100IC50>100000nM
82.7IC50=82700nM
17.2IC50=17200nM
100IC50>100000nM
100IC50>100000nM
97.6IC50=97600nM
57.2IC50=57200nM
8.4IC50=8400nM
100IC50>100000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL995570
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 10
First Page: 5434
Last Page: 5440
DOI: 10.1016/j.bmc.2008.04.016

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
21.8IC50=21800nM
98IC50=98000nM
100IC50>100000nM
0.46IC50=460nM
100IC50>100000nM
83.6IC50=83600nM
98IC50=98000nM
44.5IC50=44500nM
12.3IC50=12300nM
100IC50>100000nM
27.8IC50=27800nM
25.9IC50=25900nM
49IC50=49000nM
11.3IC50=11300nM
54.1IC50=54100nM
53.4IC50=53400nM
29.4IC50=29400nM
68.1IC50=68100nM
7.3IC50=7300nM
100IC50>100000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:MCF7
External ID: CHEMBL4035952
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
GI=6%
GI=21%
GI=0%
GI=11%
GI=0%
GI=10%
GI=26%
GI=0%
GI=0%
GI=2%
GI=2%
GI=0%
GI=17%
GI=3%
GI=16%
GI=1%
GI=27%
GI=86%
GI=73%
GI=15%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:SW480
External ID: CHEMBL4035953
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 14
First Page: 3706
Last Page: 3713
DOI: 10.1016/j.bmc.2017.05.009

Target ChEMBL ID: CHEMBL612544
ChEMBL Target Name: SW480
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
GI=21%
GI=28%
GI=43%
GI=22%
GI=16%
GI=7%
GI=25%
GI=24%
GI=19%
GI=12%
GI=4%
GI=31%
GI=34%
GI=13%
GI=20%
GI=13%
GI=9%
GI=81%
GI=58%
GI=18%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HT-1080
External ID: CHEMBL995575
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 10
First Page: 5434
Last Page: 5440
DOI: 10.1016/j.bmc.2008.04.016

Target ChEMBL ID: CHEMBL614580
ChEMBL Target Name: HT-1080
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
76.7IC50=76700nM
100IC50>100000nM
100IC50>100000nM
9.45IC50=9450nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
100IC50>100000nM
51.2IC50=51200nM
100IC50>100000nM
38.7IC50=38700nM
100IC50>100000nM
47.6IC50=47600nM
28.4IC50=28400nM
100IC50>100000nM
100IC50>100000nM
96.3IC50=96300nM
100IC50>100000nM
18.2IC50=18200nM
100IC50>100000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:DLD-1
External ID: CHEMBL1023769
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 3
First Page: 1181
Last Page: 1186
DOI: 10.1016/j.bmc.2008.12.033

Target ChEMBL ID: CHEMBL614285
ChEMBL Target Name: DLD-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
Activity=2.5