HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：9L

External ID: CHEMBL620382

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1999
Volume: 42
Issue: 5
First Page: 859
Last Page: 867
DOI: 10.1021/jm980510s

Target ChEMBL ID: CHEMBL613105
ChEMBL Target Name: 9L
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
IC50	nM	Not Determined
IC50	nM	Not Determined
IC50	nM	Not Determined
IC50	nM	Not Determined
IC50	nM	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SK-MEL-28

External ID: CHEMBL809108

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1999
Volume: 42
Issue: 5
First Page: 859
Last Page: 867
DOI: 10.1021/jm980510s

Target ChEMBL ID: CHEMBL614919
ChEMBL Target Name: SK-MEL-28
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
100	IC50	>	100000	nM
100	IC50	>	100000	nM
108	IC50	=	108000	nM	Outside typical range
100	IC50	>	100000	nM
4.5	IC50	=	4500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL818228

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 9
First Page: 2159
Last Page: 2162
DOI: 10.1016/j.bmcl.2004.02.031

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
0.53	IC50	=	530	nM
54.9	IC50	=	54900	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636810

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	155	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1637836

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ka	=	0.065	/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1637837

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ka	=	0.42	/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1637838

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	55.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636665

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	59.9	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1637839

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL/F	=	25.4	L/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636187

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	58.6	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B16

External ID: CHEMBL647182

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 1
First Page: 57
Last Page: 62
DOI: 10.1016/s0960-894x(97)10178-0

Target ChEMBL ID: CHEMBL381
ChEMBL Target Name: B16
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
IC50	nM	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636667

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	6.63	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasma

External ID: CHEMBL1636668

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL613424
ChEMBL Target Name: Plasma
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Drug uptake	=	0.832	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1637860

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CLd/F	=	15.4	L/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636820

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	7	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633406

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 9
First Page: 2159
Last Page: 2162
DOI: 10.1016/j.bmcl.2004.02.031

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	0.75	hr
T1/2	=	833.33	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636821

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Drug uptake	=	4.38	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636822

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	92.5	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636823

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	435	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636825

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	3.75	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636826

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Drug uptake	=	9.7	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636812

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	3.31	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CCRF-CEM

External ID: CHEMBL653737

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1996
Volume: 39
Issue: 9
First Page: 1757
Last Page: 1759
DOI: 10.1021/jm950836q

Target ChEMBL ID: CHEMBL382
ChEMBL Target Name: CCRF-CEM
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	ED50	>	50	uM
0.022	ED50	=	0.022	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636813

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Drug uptake	=	1.87	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CCRF-CEM

External ID: CHEMBL653738

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1996
Volume: 39
Issue: 9
First Page: 1757
Last Page: 1759
DOI: 10.1021/jm950836q

Target ChEMBL ID: CHEMBL382
ChEMBL Target Name: CCRF-CEM
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	ED50	=	50	uM
10	ED50	=	10	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636814

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	262	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636816

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	3.75	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MT2

External ID: CHEMBL713263

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1996
Volume: 39
Issue: 9
First Page: 1757
Last Page: 1759
DOI: 10.1021/jm950836q

Target ChEMBL ID: CHEMBL614184
ChEMBL Target Name: MT2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2	ED50	=	2	uM
1.5	ED50	=	1.5	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasma

External ID: CHEMBL1636817

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL613424
ChEMBL Target Name: Plasma
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Drug uptake	=	3.41	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1637859

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Vc/F	=	6.43	l

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636818

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	214	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL757722

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 9
First Page: 2159
Last Page: 2162
DOI: 10.1016/j.bmcl.2004.02.031

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
0.46	IC50	=	460	nM
100	IC50	>	100000	nM
100	IC50	>=	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon 26

External ID: CHEMBL655138

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 1
First Page: 57
Last Page: 62
DOI: 10.1016/s0960-894x(97)10178-0

Target ChEMBL ID: CHEMBL614466
ChEMBL Target Name: Colon 26
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
IC50	nM	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636827

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	112	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636828

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	749	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL694356

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1999
Volume: 42
Issue: 5
First Page: 859
Last Page: 867
DOI: 10.1021/jm980510s

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
37.9	IC50	=	37900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636830

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Tmax	=	4	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636831

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Drug uptake	=	12	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636832

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 662
Last Page: 669
DOI: 10.1128/aac.00907-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	105	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：LNCaP

External ID: CHEMBL709608

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1999
Volume: 42
Issue: 5
First Page: 859
Last Page: 867
DOI: 10.1021/jm980510s

Target ChEMBL ID: CHEMBL612518
ChEMBL Target Name: LNCaP
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL757789

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1999
Volume: 42
Issue: 5
First Page: 859
Last Page: 867
DOI: 10.1021/jm980510s

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	EC50	>	10000	nM
100	EC50	>	100000	nM
1	EC50	=	1000	nM
0.15	EC50	=	150	nM
0.26	EC50	=	260	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL757796

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1999
Volume: 42
Issue: 5
First Page: 859
Last Page: 867
DOI: 10.1021/jm980510s

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	EC90	>	10	uM
100	EC90	>	100	uM
6	EC90	=	6	uM
0.61	EC90	=	0.61	uM
3	EC90	=	3	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636886

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	568	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636887

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	790	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636888

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	979.3	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636890

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL/F	=	17.8	L/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636891

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL/F	=	29.2	L/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636892

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Vc/F	=	24.8	l

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636893

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CLd/F	=	16.3	L/hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1636878

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2009
Volume: 53
Issue: 2
First Page: 646
Last Page: 650
DOI: 10.1128/aac.00905-08

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	60.2	hr

181785-84-2 靶点实验数据