HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Collagenase 3

External ID: CHEMBL1942127

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 23
First Page: 8174
Last Page: 8187
DOI: 10.1021/jm201129m

Target ChEMBL ID: CHEMBL280
ChEMBL Target Name: Matrix metalloproteinase 13
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：72 kDa type IV collagenase

External ID: CHEMBL1942129

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 23
First Page: 8174
Last Page: 8187
DOI: 10.1021/jm201129m

Target ChEMBL ID: CHEMBL333
ChEMBL Target Name: Matrix metalloproteinase-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
500	IC50	>	500000	nM
500	IC50	>	500000	nM	Outside typical range
18	IC50	=	18000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
210	IC50	=	210000	nM
83	IC50	=	83000	nM
24	IC50	>	24000	nM
500	IC50	>	500000	nM
20	IC50	>	20000	nM
24	IC50	=	24000	nM
22	IC50	>	22000	nM
500	IC50	>	500000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Collagenase 3

External ID: CHEMBL1942128

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 23
First Page: 8174
Last Page: 8187
DOI: 10.1021/jm201129m

Target ChEMBL ID: CHEMBL280
ChEMBL Target Name: Matrix metalloproteinase 13
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
220	IC50	=	220000	nM
0.09	IC50	=	90	nM
0.001	IC50	=	1	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
97	IC50	=	97000	nM
2.4	IC50	=	2400	nM
0.12	IC50	=	120	nM
0.25	IC50	=	250	nM
500	IC50	>	500000	nM
39	IC50	=	39000	nM
2.5	IC50	=	2500	nM
0.003	IC50	=	3	nM
25	IC50	=	25000	nM
9.6	IC50	=	9600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Matrix metalloproteinase-14

External ID: CHEMBL1942130

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2011
Volume: 54
Issue: 23
First Page: 8174
Last Page: 8187
DOI: 10.1021/jm201129m

Target ChEMBL ID: CHEMBL3869
ChEMBL Target Name: Matrix metalloproteinase 14
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
500	IC50	>	500000	nM
500	IC50	>	500000	nM	Outside typical range
8.3	IC50	=	8300	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
41	IC50	=	41000	nM
11	IC50	=	11000	nM
500	IC50	>	500000	nM
22	IC50	>	22000	nM
15	IC50	=	15000	nM
22	IC50	>	22000	nM
500	IC50	>	500000	nM

179556-14-0 靶点实验数据