HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL680021

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 9
First Page: 1823
Last Page: 1835
DOI: 10.1021/jm9508651

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
6.0E-6	IC50	=	0.006	nM	Outside typical range
0.0023	IC50	=	2.3	nM
0.0026	IC50	=	2.6	nM
0.011	IC50	=	11	nM
0.0031	IC50	=	3.1	nM
0.0096	IC50	=	9.6	nM
0.124	IC50	=	124	nM
0.051	IC50	=	51	nM
2.03	IC50	=	2030	nM
0.052	IC50	=	52	nM
0.013	IC50	=	13	nM
0.263	IC50	=	263	nM
0.324	IC50	=	324	nM
0.034	IC50	=	34	nM
0.03	IC50	=	30	nM
0.035	IC50	=	35	nM
0.01	IC50	=	10	nM
0.029	IC50	=	29	nM
0.578	IC50	=	578	nM
0.009	IC50	=	9	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_546_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		1.46		1460	P00533	BDBM3587	Epidermal growth factor receptor
IC50		0.1		100	P00533	BDBM3589	Epidermal growth factor receptor
IC50		0.035		35	P00533	BDBM3590	Epidermal growth factor receptor
IC50		0.013		13	P00533	BDBM3593	Epidermal growth factor receptor
IC50		1.3E-4		0.13	P00533	BDBM3594	Epidermal growth factor receptor
IC50		9.1E-5		0.091	P00533	BDBM3595	Epidermal growth factor receptor
IC50		0.039		39	P00533	BDBM3596	Epidermal growth factor receptor
IC50		0.051		51	P00533	BDBM3599	Epidermal growth factor receptor
IC50		0.124		124	P00533	BDBM3602	Epidermal growth factor receptor
IC50		8.0E-6		0.008	P00533	BDBM3603	Epidermal growth factor receptor
IC50		6.0E-6		0.006	P00533	BDBM3604	Epidermal growth factor receptor
IC50		0.0026		2.6	P00533	BDBM3605	Epidermal growth factor receptor
IC50		0.0023		2.3	P00533	BDBM3606	Epidermal growth factor receptor
IC50		0.009		9	P00533	BDBM3607	Epidermal growth factor receptor
IC50	>	10	>	10000	P00533	BDBM3608	Epidermal growth factor receptor
IC50		0.324		324	P00533	BDBM3613	Epidermal growth factor receptor
IC50		0.263		263	P00533	BDBM3614	Epidermal growth factor receptor
IC50		0.603		603	P00533	BDBM3615	Epidermal growth factor receptor
IC50		0.034		34	P00533	BDBM3616	Epidermal growth factor receptor
IC50		0.0076		7.6	P00533	BDBM3617	Epidermal growth factor receptor

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL677215

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 9
First Page: 1823
Last Page: 1835
DOI: 10.1021/jm9508651

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.012	IC50	=	12	nM
0.02	IC50	=	20	nM
0.032	IC50	=	32	nM
0.016	IC50	=	16	nM
0.11	IC50	=	110	nM
2.085	IC50	=	2085	nM
0.014	IC50	=	14	nM
0.016	IC50	=	16	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL621853

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 5
First Page: 742
Last Page: 751
DOI: 10.1021/jm970641d

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0059	IC50	=	5.9	nM
0.046	IC50	=	46	nM
0.23	IC50	=	230	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL674648

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 5
First Page: 742
Last Page: 751
DOI: 10.1021/jm970641d

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1.9E-4	IC50	=	0.19	nM
0.001	IC50	=	1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_552_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	6.0E-6	0.006	P00533	BDBM3604	Epidermal growth factor receptor
IC50	0.009	9	P00533	BDBM3607	Epidermal growth factor receptor
IC50	1.9E-4	0.19	P00533	BDBM3700	Epidermal growth factor receptor

175357-96-7 靶点实验数据