HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transthyretin

External ID: CHEMBL4413998

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 4
First Page: 2076
Last Page: 2082
DOI: 10.1021/acs.jmedchem.8b01700

Target ChEMBL ID: CHEMBL3194
ChEMBL Target Name: Transthyretin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL917611

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 5
First Page: 1007
Last Page: 1018
DOI: 10.1021/jm061162u

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
24	IC50	=	24000	nM
0.001	IC50	=	1	nM
19	IC50	=	19000	nM
25	IC50	=	25000	nM
31	IC50	=	31000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL917612

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 5
First Page: 1007
Last Page: 1018
DOI: 10.1021/jm061162u

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
21	IC50	=	21000	nM
0.001	IC50	=	1	nM
10	IC50	=	10000	nM
14	IC50	=	14000	nM
24	IC50	=	24000	nM
100	IC50	>	100000	nM
37	IC50	=	37000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MIA PaCa-2

External ID: CHEMBL917613

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 5
First Page: 1007
Last Page: 1018
DOI: 10.1021/jm061162u

Target ChEMBL ID: CHEMBL614725
ChEMBL Target Name: MIA PaCa-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
32	IC50	=	32000	nM
0.001	IC50	=	1	nM
15	IC50	=	15000	nM
23	IC50	=	23000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
71	IC50	=	71000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gallus gallus

External ID: CHEMBL656664

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 4
First Page: 590
Last Page: 592
DOI: 10.1021/jm00358a025

Target ChEMBL ID: CHEMBL613109
ChEMBL Target Name: Gallus gallus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Lethal dose	=	0.01	p.p.m.
Lethal dose	=	81	p.p.m.
Lethal dose	=	81	p.p.m.
Lethal dose	=	81	p.p.m.
Lethal dose	=	9	p.p.m.
Lethal dose	=	81	p.p.m.
Lethal dose	=	81	p.p.m.
Lethal dose	=	81	p.p.m.
Lethal dose	=	0.33	p.p.m.
Lethal dose	=	1	p.p.m.

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transthyretin

External ID: CHEMBL4413992

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 4
First Page: 2076
Last Page: 2082
DOI: 10.1021/acs.jmedchem.8b01700

Target ChEMBL ID: CHEMBL3194
ChEMBL Target Name: Transthyretin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	98	%
Activity	=	100	%
Activity	=	110	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL1815949

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2011
Volume: 46
Issue: 8
First Page: 3444
Last Page: 3454
DOI: 10.1016/j.ejmech.2011.05.009

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
380.189	IC50	=	380189.4	nM	Outside typical range
1584.89	IC50	=	1584893.19	nM	Outside typical range
16.9824	IC50	=	16982.44	nM
1584.89	IC50	=	1584893.19	nM	Outside typical range
45.7088	IC50	=	45708.82	nM
1584.89	IC50	=	1584893.19	nM	Outside typical range
75.8578	IC50	=	75857.76	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transthyretin

External ID: CHEMBL4413993

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 4
First Page: 2076
Last Page: 2082
DOI: 10.1021/acs.jmedchem.8b01700

Target ChEMBL ID: CHEMBL3194
ChEMBL Target Name: Transthyretin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	88	%
Activity	=	100	%
Activity	=	99	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SW-620

External ID: CHEMBL917614

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 5
First Page: 1007
Last Page: 1018
DOI: 10.1021/jm061162u

Target ChEMBL ID: CHEMBL612262
ChEMBL Target Name: SW-620
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
72	IC50	=	72000	nM
1.0E-4	IC50	=	0.1	nM
19	IC50	=	19000	nM
6	IC50	=	6000	nM
39	IC50	=	39000	nM
100	IC50	>	100000	nM
40	IC50	=	40000	nM
100	IC50	>=	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transthyretin

External ID: CHEMBL4413994

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 4
First Page: 2076
Last Page: 2082
DOI: 10.1021/acs.jmedchem.8b01700

Target ChEMBL ID: CHEMBL3194
ChEMBL Target Name: Transthyretin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	110	%
Activity	=	100	%
Activity	=	74	%
Activity	=	58	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL917615

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 5
First Page: 1007
Last Page: 1018
DOI: 10.1021/jm061162u

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
0.5	IC50	=	500	nM
8	IC50	=	8000	nM
25	IC50	=	25000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
44	IC50	=	44000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

17455-13-9 靶点实验数据