HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B16

External ID: CHEMBL648780

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL381
ChEMBL Target Name: B16
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	38	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL760218

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	107	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：M5076

External ID: CHEMBL707622

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL614120
ChEMBL Target Name: M5076
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	74	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL703478

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	56	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL762217

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
ILSmax	=	35
ILSmax	=	80
ILSmax	=	107
ILSmax	=	80
ILSmax	=	51
ILSmax	=	40
ILSmax	=	70
ILSmax	=	50
ILSmax	=	38
ILSmax	=	60
ILSmax	=	35
ILSmax	=	86
ILSmax	=	60

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lewis lung carcinoma cell line

External ID: CHEMBL711990

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL614088
ChEMBL Target Name: Lewis lung carcinoma cell line
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	69	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B16

External ID: CHEMBL652824

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL381
ChEMBL Target Name: B16
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
67	IC50	=	67000	nM
100	IC50	>	100000	nM
50	IC50	=	50000	nM
100	IC50	>	100000	nM
7	IC50	=	7000	nM
100	IC50	>	100000	nM
13	IC50	=	13000	nM
66	IC50	=	66000	nM
100	IC50	>	100000	nM
7	IC50	=	7000	nM
10	IC50	=	10000	nM
6	IC50	=	6000	nM
6	IC50	=	6000	nM
2	IC50	=	2000	nM
100	IC50	>	100000	nM
50	IC50	=	50000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL723207

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MTD	=	95	uM kg-1
MTD	=	60	uM kg-1
MTD	=	50	uM kg-1
MTD	=	60	uM kg-1
MTD	=	320	uM kg-1
MTD	=	300	uM kg-1
MTD	=	110	uM kg-1
MTD	=	670	uM kg-1
MTD	=	320	uM kg-1
MTD	=	120	uM kg-1
MTD	=	72	uM kg-1
MTD	>	600	uM kg-1
MTD	=	280	uM kg-1
MTD	=	18	uM kg-1
MTD	=	48	uM kg-1
MTD	=	82	uM kg-1
MTD	>	300	uM kg-1
MTD	=	1000	uM kg-1
MTD	=	17	uM kg-1
MTD	=	80	uM kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL712982

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL832413

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 4
First Page: 977
Last Page: 985
DOI: 10.1021/jm049430g

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.25	ug.mL-1
IC50	=	0.05	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：ADJ/PC6

External ID: CHEMBL620507

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL614265
ChEMBL Target Name: ADJ/PC6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
TGI	=	94	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL823536

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1987
Volume: 30
Issue: 12
First Page: 2181
Last Page: 2190
DOI: 10.1021/jm00395a004

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
TGI	=	88	%

1663-45-2 靶点实验数据