HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614766

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	46	%
F	=	47	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Complement factor B

External ID: CHEMBL4614752

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Target ChEMBL ID: CHEMBL5731
ChEMBL Target Name: Complement factor B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
68	IC50	=	68000	nM
36	IC50	=	36000	nM
0.018	IC50	=	18	nM
0.024	IC50	=	24	nM
12	IC50	=	12000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614756

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
CL	<	3.4	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614758

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
Papp	=	16.6	10'-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614757

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	54.1	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_754_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.18	180	P00751	BDBM159157	Complement factor B
IC50	8.3	8300	P00751	BDBM159192	Complement factor B
IC50	1.5	1500	P00751	BDBM159287	Complement factor B
IC50	1.3	1300	P00751	BDBM159288	Complement factor B
IC50	0.037	37	P00751	BDBM159289	Complement factor B
IC50	9.4	9400	P00751	BDBM159292	Complement factor B
IC50	0.14	140	P00751	BDBM159303	Complement factor B
IC50	0.013	13	P00751	BDBM159545	Complement factor B
IC50	0.1	100	P00751	BDBM159841	Complement factor B
IC50	1.7	1700	P00751	BDBM159844	Complement factor B
IC50	1.1	1100	P00751	BDBM160475	Complement factor B
IC50	1.5	1500	P00751	BDBM160487	Complement factor B
IC50	3.4	3400	P00751	BDBM160487	Complement factor B
IC50	3.4	3400	P00751	BDBM160487	Complement factor B
IC50	8.2	8200	P00751	BDBM160490	Complement factor B
IC50	0.022	22	P00751	BDBM160500	Complement factor B
IC50	0.13	130	P00751	BDBM160501	Complement factor B

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614760

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	16	mL.min-1.kg-1
CL	=	6.8	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614759

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
Papp	=	0.6	10'-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614762

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	7.2	hr
T1/2	=	4.9	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614761

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	6.6	L.kg-1
Vdss	=	3.1	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614764

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
AUC	=	3211.23	ng.hr.mL-1	standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW
AUC	=	6198.24	ng.hr.mL-1	standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4614763

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 11
First Page: 5697
Last Page: 5722
DOI: 10.1021/acs.jmedchem.9b01870

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	1.6	hr
MRT	=	2.3	hr

1644669-75-9 靶点实验数据