HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2OS

External ID: CHEMBL5724701

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL615023
ChEMBL Target Name: U2OS
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
autophagy induction	=	1.311	%
autophagy induction	=	2.21	%
autophagy induction	=	-1.399	%
autophagy induction	=	-21.98	%
autophagy induction	=	12.27	%
autophagy induction	=	3.055	%
autophagy induction	=	0.8075	%
autophagy induction	=	-5.198	%
autophagy induction	=	0.1217	%
autophagy induction	=	-4.73	%
autophagy induction	=	-6.08	%
autophagy induction	=	-12.76	%
autophagy induction	=	-15.06	%
autophagy induction	=	-6.645	%
autophagy induction	=	-7.125	%
autophagy induction	=	-16.28	%
autophagy induction	=	-9.31	%
autophagy induction	=	-9.369	%
autophagy induction	=	-11.21	%
autophagy induction	=	-4.989	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL5062802

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.1409	C	Thermal Shift Assay
Delta TM	=	-0.01457	C	Thermal Shift Assay
Delta TM	=	-0.19	C
Delta TM	=	1.16	C	Thermal Shift Assay
Delta TM	=	1.921	C	Thermal Shift Assay
Delta TM	=	-0.3406	C	Thermal Shift Assay
Delta TM	=	0.6	C	Thermal Shift Assay
Delta TM	=	-0.1127	C	Thermal Shift Assay
Delta TM	=	-1.169	C	Thermal Shift Assay
Delta TM	=	0.82	C
Delta TM	=	0.31	C	Thermal Shift Assay
Delta TM	=	-0.02	C	Thermal Shift Assay
Delta TM	=	0.46	C	Thermal Shift Assay
Delta TM	=	-1.475	C	Thermal Shift Assay
Delta TM	=	-0.6313	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.6762	C	Thermal Shift Assay
Delta TM	=	1.46	C	Thermal Shift Assay
Delta TM	=	0.98	C	Thermal Shift Assay
Delta TM	=	0.83	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2OS

External ID: CHEMBL5724700

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL615023
ChEMBL Target Name: U2OS
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
autophagy induction	=	-2.464	%
autophagy induction	=	-2.287	%
autophagy induction	=	-1.179	%
autophagy induction	=	114.19	%
autophagy induction	=	-2.891	%
autophagy induction	=	-2.398	%
autophagy induction	=	-2.288	%
autophagy induction	=	114.25	%
autophagy induction	=	-6.232	%
autophagy induction	=	-4.153	%
autophagy induction	=	-3.872	%
autophagy induction	=	114.44	%
autophagy induction	=	-1.434	%
autophagy induction	=	-1.039	%
autophagy induction	=	-0.6288	%
autophagy induction	=	-0.1138	%
autophagy induction	=	-9.274	%
autophagy induction	=	-4.861	%
autophagy induction	=	-2.29	%
autophagy induction	=	-1.949	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL5063037

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-0.2647	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL5065589

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	5.443	C	Thermal Shift Assay
Delta TM	=	-0.3085	C	Thermal Shift Assay
Delta TM	=	-0.7	C
Delta TM	=	-0.03	C	Thermal Shift Assay
Delta TM	=	11.17	C	Thermal Shift Assay
Delta TM	=	-1.553	C	Thermal Shift Assay
Delta TM	=	-0.29	C	Thermal Shift Assay
Delta TM	=	-0.3615	C	Thermal Shift Assay
Delta TM	=	0.0664	C	Thermal Shift Assay
Delta TM	=	-0.66	C
Delta TM	=	-0.06	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	-0.26	C	Thermal Shift Assay
Delta TM	=	-1.145	C	Thermal Shift Assay
Delta TM	=	-0.6697	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.4876	C	Thermal Shift Assay
Delta TM	=	2.74	C	Thermal Shift Assay
Delta TM	=	0.22	C	Thermal Shift Assay
Delta TM	=	-0.06	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL5060015

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	2.866	C	Thermal Shift Assay
Delta TM	=	-0.1161	C	Thermal Shift Assay
Delta TM	=	0.32	C
Delta TM	=	0.12	C	Thermal Shift Assay
Delta TM	=	1.321	C	Thermal Shift Assay
Delta TM	=	-0.3289	C	Thermal Shift Assay
Delta TM	=	0.97	C	Thermal Shift Assay
Delta TM	=	-0.00477	C	Thermal Shift Assay
Delta TM	=	0.8545	C	Thermal Shift Assay
Delta TM	=	0.25	C
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.01	C	Thermal Shift Assay
Delta TM	=	0.57	C	Thermal Shift Assay
Delta TM	=	-0.2514	C	Thermal Shift Assay
Delta TM	=	-0.09405	C	Thermal Shift Assay
Delta TM	=	0.1211	C	Thermal Shift Assay
Delta TM	=	0.2152	C	Thermal Shift Assay
Delta TM	=	4.95	C	Thermal Shift Assay
Delta TM	=	0.78	C	Thermal Shift Assay
Delta TM	=	0.49	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N-formyl peptide receptor 2

External ID: CHEMBL5209826

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4227
ChEMBL Target Name: Lipoxin A4 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	20.59	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.14	%	Agonist %Max (Mean)
%Inhib (Mean)	=	14.37	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.69	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-16.6	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.48	%	Agonist %Max (Mean)
%Max (Mean)	=	1.81	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-36.4	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-6.18	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.47	%	Agonist %Max (Mean)
%Inhib (Mean)	=	18.01	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.849	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-28.76	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.95	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-2.24	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	61.06	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.41	%	Agonist %Max (Mean)
%Inhib (Mean)	=	35.08	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.569	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-26.45	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucagon-like peptide 1 receptor

External ID: CHEMBL5209829

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1784
ChEMBL Target Name: Glucagon-like peptide 1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Max (Mean)	=	-0.52	%	Agonist %Max (Mean)
%Inhib (Mean)	=	1.9	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	46.53	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.81	%	Agonist %Max (Mean)
%Max (Mean)	=	0	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-17.37	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.31	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-42.05	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-9.7	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.12	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-9.08	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.168	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-39.97	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.14	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-34.58	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	56.23	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0	%	Agonist %Max (Mean)
%Inhib (Mean)	=	66.71	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.9215	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-18.07	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Free fatty acid receptor 4

External ID: CHEMBL5209823

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5339
ChEMBL Target Name: G-protein coupled receptor 120
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Max (Mean)	=	-1.859	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-35.14	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-32.8	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-32.11	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.3	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-53.6	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.4171	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-68.27	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.637	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-35.64	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	1.5	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-347.9	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-179.97	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-6.66	%	Agonist %Max (Mean)
%Inhib (Mean)	=	69.11	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-41.58	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.8	%	Agonist %Max (Mean)
%Inhib (Mean)	=	0.7	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	29.29	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4303805

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	-11.52	%	Outside typical range
Inhibition	=	5.09	%
Inhibition	=	-1.71	%
Inhibition	=	3.69	%
Inhibition	=	22.47	%
Inhibition	=	8.51	%
Inhibition	=	-6.86	%
Inhibition	=	-6.18	%
Inhibition	=	-2.07	%
Inhibition	=	3.91	%
Inhibition	=	-5.9	%
Inhibition	=	-2.45	%
Inhibition	=	-5.55	%
Inhibition	=	6.31	%
Inhibition	=	-1.08	%
Inhibition	=	12.7	%
Inhibition	=	0.37	%
Inhibition	=	8.88	%
Inhibition	=	11.63	%
Inhibition	=	-1.96	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CX3C chemokine receptor 1

External ID: CHEMBL5209820

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4843
ChEMBL Target Name: C-X3-C chemokine receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Max (Mean)	=	-1.649	%	Agonist %Max (Mean)
%Inhib (Mean)	=	64.96	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	51.4	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.1251	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-25.26	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.78	%	Agonist %Max (Mean)
%Max (Mean)	=	-1.438	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-13.1	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.643	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-12	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-43.54	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.23	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-36.45	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.3693	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-17.78	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.914	%	Agonist %Max (Mean)
%Inhib (Mean)	=	60.09	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	70.16	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.07	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-31.3	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Apelin receptor

External ID: CHEMBL5209814

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1628481
ChEMBL Target Name: Apelin receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	51.27	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.352	%	Agonist %Max (Mean)
%Inhib (Mean)	=	48.63	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	15.2	%	Agonist %Max (Mean)
%Max (Mean)	=	0.339	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-14.84	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.176	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-17.21	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-3.54	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	1.328	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-25.88	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.284	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-44.48	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.987	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-2.87	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	77	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.532	%	Agonist %Max (Mean)
%Inhib (Mean)	=	77.31	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.986	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-19.81	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：C5a anaphylatoxin chemotactic receptor 1

External ID: CHEMBL5209817

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2373
ChEMBL Target Name: C5a anaphylatoxin chemotactic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	41.88	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-6.354	%	Agonist %Max (Mean)
%Inhib (Mean)	=	57.31	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.321	%	Agonist %Max (Mean)
%Inhib (Mean)	=	17.1	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.91	%	Agonist %Max (Mean)
%Max (Mean)	=	-2.603	%	Agonist %Max (Mean)
%Inhib (Mean)	=	0.05788	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-1.92	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.3276	%	Agonist %Max (Mean)
%Inhib (Mean)	=	51.77	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.185	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-53.58	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-4.451	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-15.51	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	63.75	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.4841	%	Agonist %Max (Mean)
%Inhib (Mean)	=	18.37	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.514	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-7.5	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type-1 angiotensin II receptor

External ID: CHEMBL5209811

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL227
ChEMBL Target Name: Type-1 angiotensin II receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	52.25	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.364	%	Agonist %Max (Mean)
%Inhib (Mean)	=	55.1	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.3098	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-3.515	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.68	%	Agonist %Max (Mean)
%Max (Mean)	=	-1.646	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-16.52	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	5.94	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	9.93	%	Agonist %Max (Mean)
%Inhib (Mean)	=	18.15	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-4.71	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-29.3	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.695	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-9.202	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.3162	%	Agonist %Max (Mean)
%Inhib (Mean)	=	38.16	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	75.45	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.5	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-20.38	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase A

External ID: CHEMBL5067682

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4722
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.00527	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-2 adrenergic receptor

External ID: CHEMBL5209808

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL210
ChEMBL Target Name: Beta-2 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	58.93	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-4.19	%	Agonist %Max (Mean)
%Inhib (Mean)	=	65.7	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.47	%	Agonist %Max (Mean)
%Max (Mean)	=	-1.59	%	Agonist %Max (Mean)
%Inhib (Mean)	=	6.99	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.64	%	Agonist %Max (Mean)
%Inhib (Mean)	=	8.59	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.07	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-60.51	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-68.38	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.115	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-39.37	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.53	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-0.41	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	72.72	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.99	%	Agonist %Max (Mean)
%Inhib (Mean)	=	62.59	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.9984	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-30.45	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adhesion G-protein coupled receptor F1

External ID: CHEMBL5209802

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4523872
ChEMBL Target Name: Adhesion G-protein coupled receptor F1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	35.28	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	28.31	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.874	%	Agonist %Max (Mean)
%Max (Mean)	=	19.43	%	Agonist %Max (Mean)
%Max (Mean)	=	9.721	%	Agonist %Max (Mean)
%Inhib (Mean)	=	6.04	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	4.847	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-30.63	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-35.08	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-15.65	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.759	%	Agonist %Max (Mean)
%Max (Mean)	=	21.01	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-45.16	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	10.52	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-18.11	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	49.92	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	95.59	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-13.68	%	Agonist %Max (Mean)
%Max (Mean)	=	9.4	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-36.42	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-2A adrenergic receptor

External ID: CHEMBL5209805

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1867
ChEMBL Target Name: Alpha-2a adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Max (Mean)	=	-4.6	%	Agonist %Max (Mean)
%Inhib (Mean)	=	48.8	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	26.05	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.89	%	Agonist %Max (Mean)
%Max (Mean)	=	0.4	%	Agonist %Max (Mean)
%Inhib (Mean)	=	4.5	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	8.6	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-3.8	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-19.74	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	4.5	%	Agonist %Max (Mean)
%Inhib (Mean)	=	3.9	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.71	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-32.79	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	4.8	%	Agonist %Max (Mean)
%Inhib (Mean)	=	8	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	8.5	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-11.1	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	57.67	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-0.24	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-23.02	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL5060250

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-0.1301	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1

External ID: CHEMBL5442228

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL216
ChEMBL Target Name: Muscarinic acetylcholine receptor M1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-6.06	%	Inactive
Inhibition	=	-10.04	%	Inactive	Outside typical range
Inhibition	=	-7.47	%	Inactive
Inhibition	=	-8.77	%	Inactive
Inhibition	=	-21.47	%	Inactive	Outside typical range
Inhibition	=	5.19	%	Inactive
Inhibition	=	-9.03	%	Inactive
Inhibition	=	-11.74	%	Inactive	Outside typical range
Inhibition	=	18.47	%	Inactive
Inhibition	=	-10.78	%	Inactive	Outside typical range
Inhibition	=	-13.23	%	Inactive	Outside typical range
Inhibition	=	66.4	%	Active
Inhibition	=	13.16	%	Inactive
Inhibition	=	-11.75	%	Inactive	Outside typical range
Inhibition	=	-10.9	%	Inactive	Outside typical range
Inhibition	=	4.09	%	Inactive
Inhibition	=	20.75	%	Inactive
Inhibition	=	-14.78	%	Inactive	Outside typical range
Inhibition	=	-4.88	%	Inactive
Inhibition	=	-35.02	%	Inactive	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-2 adrenergic receptor

External ID: CHEMBL5442227

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL210
ChEMBL Target Name: Beta-2 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-4.07	%	Inactive
Inhibition	=	-1.29	%	Inactive
Inhibition	=	-15.71	%	Inactive	Outside typical range
Inhibition	=	-17.06	%	Inactive	Outside typical range
Inhibition	=	-4.38	%	Inactive
Inhibition	=	4.31	%	Inactive
Inhibition	=	97.78	%	Active
Inhibition	=	100.23	%	Active
Inhibition	=	1.44	%	Inactive
Inhibition	=	-13.29	%	Inactive	Outside typical range
Inhibition	=	-11.07	%	Inactive	Outside typical range
Inhibition	=	10.44	%	Inactive
Inhibition	=	5.86	%	Inactive
Inhibition	=	34.2	%	Inactive
Inhibition	=	-7.15	%	Inactive
Inhibition	=	3.05	%	Inactive
Inhibition	=	99.01	%	Active
Inhibition	=	-6.03	%	Inactive
Inhibition	=	3.89	%	Inactive
Inhibition	=	-2.94	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-1 adrenergic receptor

External ID: CHEMBL5442226

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL213
ChEMBL Target Name: Beta-1 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	18.51	%	Inactive
Inhibition	=	11.98	%	Inactive
Inhibition	=	-6.31	%	Inactive
Inhibition	=	-2.63	%	Inactive
Inhibition	=	-14.28	%	Inactive	Outside typical range
Inhibition	=	13.85	%	Inactive
Inhibition	=	95.96	%	Active
Inhibition	=	70.92	%	Active
Inhibition	=	18.96	%	Inactive
Inhibition	=	18.3	%	Inactive
Inhibition	=	16.99	%	Inactive
Inhibition	=	-1.95	%	Inactive
Inhibition	=	36.27	%	Inactive
Inhibition	=	37.02	%	Inactive
Inhibition	=	29.92	%	Inactive
Inhibition	=	-21.92	%	Inactive	Outside typical range
Inhibition	=	31.05	%	Inactive
Inhibition	=	-38.45	%	Inactive	Outside typical range
Inhibition	=	-12.31	%	Inactive	Outside typical range
Inhibition	=	26.6	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-2C adrenergic receptor

External ID: CHEMBL5442225

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1916
ChEMBL Target Name: Alpha-2c adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-0.86	%	Inactive
Inhibition	=	-15.64	%	Inactive	Outside typical range
Inhibition	=	-5.48	%	Inactive
Inhibition	=	-11.77	%	Inactive	Outside typical range
Inhibition	=	12.31	%	Inactive
Inhibition	=	-0.17	%	Inactive
Inhibition	=	1.66	%	Inactive
Inhibition	=	1.35	%	Inactive
Inhibition	=	94.9	%	Active
Inhibition	=	12.02	%	Inactive
Inhibition	=	1.59	%	Inactive
Inhibition	=	37.95	%	Inactive
Inhibition	=	15.13	%	Inactive
Inhibition	=	66.67	%	Active
Inhibition	=	28.37	%	Inactive
Inhibition	=	25.36	%	Inactive
Inhibition	=	82.55	%	Active
Inhibition	=	-7.17	%	Inactive
Inhibition	=	-1.89	%	Inactive
Inhibition	=	4.08	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-2B adrenergic receptor

External ID: CHEMBL5442224

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1942
ChEMBL Target Name: Alpha-2b adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-2.94	%	Inactive
Inhibition	=	11.47	%	Inactive
Inhibition	=	2.24	%	Inactive
Inhibition	=	-2.96	%	Inactive
Inhibition	=	7.07	%	Inactive
Inhibition	=	34.74	%	Inactive
Inhibition	=	-0.72	%	Inactive
Inhibition	=	-0.6	%	Inactive
Inhibition	=	83.96	%	Active
Inhibition	=	15.17	%	Inactive
Inhibition	=	3.23	%	Inactive
Inhibition	=	69.49	%	Active
Inhibition	=	-1.21	%	Inactive
Inhibition	=	53.01	%	Active
Inhibition	=	28.08	%	Inactive
Inhibition	=	9.01	%	Inactive
Inhibition	=	69.72	%	Active
Inhibition	=	-23.44	%	Inactive	Outside typical range
Inhibition	=	9.08	%	Inactive
Inhibition	=	-2.75	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-2A adrenergic receptor

External ID: CHEMBL5442223

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1867
ChEMBL Target Name: Alpha-2a adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-44.43	%	Inactive	Outside typical range
Inhibition	=	8.96	%	Inactive
Inhibition	=	0.09	%	Inactive
Inhibition	=	4.57	%	Inactive
Inhibition	=	13.89	%	Inactive
Inhibition	=	11.2	%	Inactive
Inhibition	=	11.8	%	Inactive
Inhibition	=	29.02	%	Inactive
Inhibition	=	98.81	%	Active
Inhibition	=	13.99	%	Inactive
Inhibition	=	11.14	%	Inactive
Inhibition	=	72.99	%	Active
Inhibition	=	-7.52	%	Inactive
Inhibition	=	49.09	%	Inactive
Inhibition	=	6.44	%	Inactive
Inhibition	=	17.75	%	Inactive
Inhibition	=	84.59	%	Active
Inhibition	=	-16.61	%	Inactive	Outside typical range
Inhibition	=	13.41	%	Inactive
Inhibition	=	-22.55	%	Inactive	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1D adrenergic receptor

External ID: CHEMBL5442222

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL223
ChEMBL Target Name: Alpha-1d adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	6.55	%	Inactive
Inhibition	=	-5.37	%	Inactive
Inhibition	=	-15.6	%	Inactive	Outside typical range
Inhibition	=	11.02	%	Inactive
Inhibition	=	-13.69	%	Inactive	Outside typical range
Inhibition	=	-0.46	%	Inactive
Inhibition	=	8.6	%	Inactive
Inhibition	=	13.64	%	Inactive
Inhibition	=	97.84	%	Active
Inhibition	=	19.52	%	Inactive
Inhibition	=	11.1	%	Inactive
Inhibition	=	66.33	%	Active
Inhibition	=	18.28	%	Inactive
Inhibition	=	12.09	%	Inactive
Inhibition	=	13.01	%	Inactive
Inhibition	=	-10.1	%	Inactive	Outside typical range
Inhibition	=	86.54	%	Active
Inhibition	=	-25.82	%	Inactive	Outside typical range
Inhibition	=	6.2	%	Inactive
Inhibition	=	-7.75	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1B adrenergic receptor

External ID: CHEMBL5442221

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL232
ChEMBL Target Name: Alpha-1b adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	13.44	%	Inactive
Inhibition	=	1.22	%	Inactive
Inhibition	=	-5.54	%	Inactive
Inhibition	=	-4.11	%	Inactive
Inhibition	=	-15.82	%	Inactive	Outside typical range
Inhibition	=	-6.37	%	Inactive
Inhibition	=	-6.31	%	Inactive
Inhibition	=	6.47	%	Inactive
Inhibition	=	95.88	%	Active
Inhibition	=	-3.95	%	Inactive
Inhibition	=	1.04	%	Inactive
Inhibition	=	16.35	%	Inactive
Inhibition	=	32.38	%	Inactive
Inhibition	=	2.3	%	Inactive
Inhibition	=	12.86	%	Inactive
Inhibition	=	10.19	%	Inactive
Inhibition	=	81.58	%	Active
Inhibition	=	-9.67	%	Inactive
Inhibition	=	-27.6	%	Inactive	Outside typical range
Inhibition	=	13.16	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1A adrenergic receptor

External ID: CHEMBL5442220

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL229
ChEMBL Target Name: Alpha-1a adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-4	%	Inactive
Inhibition	=	-4.46	%	Inactive
Inhibition	=	11.36	%	Inactive
Inhibition	=	3.1	%	Inactive
Inhibition	=	-7.27	%	Inactive
Inhibition	=	2.69	%	Inactive
Inhibition	=	2.77	%	Inactive
Inhibition	=	32	%	Inactive
Inhibition	=	96.85	%	Active
Inhibition	=	8.06	%	Inactive
Inhibition	=	-7.95	%	Inactive
Inhibition	=	27.94	%	Inactive
Inhibition	=	17.7	%	Inactive
Inhibition	=	6.21	%	Inactive
Inhibition	=	1.19	%	Inactive
Inhibition	=	16.8	%	Inactive
Inhibition	=	90.69	%	Active
Inhibition	=	-9.2	%	Inactive
Inhibition	=	1.85	%	Inactive
Inhibition	=	-15.57	%	Inactive	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Replicase polyprotein 1ab

External ID: CHEMBL4495582

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13.77	%
Inhibition	=	2.35	%
Inhibition	=	21.17	%
Inhibition	=	18.36	%
Inhibition	=	5.381	%
Inhibition	=	18.17	%
Inhibition	=	10.15	%
Inhibition	=	29.56	%
Inhibition	=	18.27	%
Inhibition	=	11.42	%
Inhibition	=	15.4	%
Inhibition	=	7.437	%
Inhibition	=	-3.216	%
Inhibition	=	18	%
Inhibition	=	1.021	%
Inhibition	=	16.4	%
Inhibition	=	2.544	%
Inhibition	=	19.11	%
Inhibition	=	26.15	%
Inhibition	=	5.133	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fibroblast growth factor receptor 3

External ID: CHEMBL5064895

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2742
ChEMBL Target Name: Fibroblast growth factor receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-0.2928	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase A

External ID: CHEMBL5067447

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4722
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.05675	C	Thermal Shift Assay
Delta TM	=	0.06056	C	Thermal Shift Assay
Delta TM	=	-0.26	C
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.2158	C	Thermal Shift Assay
Delta TM	=	0.1132	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	0.07973	C	Thermal Shift Assay
Delta TM	=	0.3724	C	Thermal Shift Assay
Delta TM	=	-0.3	C
Delta TM	=	-0.04	C	Thermal Shift Assay
Delta TM	=	-0.08	C	Thermal Shift Assay
Delta TM	=	-0.49	C	Thermal Shift Assay
Delta TM	=	0.08515	C	Thermal Shift Assay
Delta TM	=	0.01057	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	0.1944	C	Thermal Shift Assay
Delta TM	=	2.51	C	Thermal Shift Assay
Delta TM	=	-0.01	C	Thermal Shift Assay
Delta TM	=	-0.24	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：G-protein coupled receptor 35

External ID: CHEMBL5209835

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1293267
ChEMBL Target Name: G-protein coupled receptor 35
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Max (Mean)	=	8.88	%	Agonist %Max (Mean)
%Inhib (Mean)	=	39.56	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	6.1	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-28.41	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	19.34	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-41.92	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	11.62	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-20.72	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	1.634	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-27.58	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	18.15	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-21.98	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.15	%	Agonist %Max (Mean)
%Inhib (Mean)	=	46.26	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.2834	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-13.78	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	2.683	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-23.32	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	15.06	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-44.17	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 1

External ID: CHEMBL5209836

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4333
ChEMBL Target Name: Sphingosine 1-phosphate receptor Edg-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	28.93	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.018	%	Agonist %Max (Mean)
%Inhib (Mean)	=	47.4	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.59	%	Agonist %Max (Mean)
%Max (Mean)	=	78.05	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-9.8	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	9.97	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-17.5	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-3.032	%	Agonist %Max (Mean)
%Inhib (Mean)	=	19	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-10.76	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-4.23	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-41.51	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.953	%	Agonist %Max (Mean)
%Inhib (Mean)	=	12.7	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	64.16	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	7.191	%	Agonist %Max (Mean)
%Inhib (Mean)	=	24.4	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-5.2	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-29.3	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucose-dependent insulinotropic receptor

External ID: CHEMBL5209832

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5652
ChEMBL Target Name: Glucose-dependent insulinotropic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
%Inhib (Mean)	=	43.38	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	1.857	%	Agonist %Max (Mean)
%Inhib (Mean)	=	70.66	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.54	%	Agonist %Max (Mean)
%Max (Mean)	=	0.4373	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-5.458	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.9517	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-2.657	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	0.3828	%	Agonist %Max (Mean)
%Inhib (Mean)	=	31.76	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	-13.48	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.472	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-12.35	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.503	%	Agonist %Max (Mean)
%Inhib (Mean)	=	14.46	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-2.462	%	Agonist %Max (Mean)
%Inhib (Mean)	=	82.11	%	Antagonist %Inhib (Mean)
%Inhib (Mean)	=	79.17	%	Antagonist %Inhib (Mean)
%Max (Mean)	=	-1.276	%	Agonist %Max (Mean)
%Inhib (Mean)	=	-4.84	%	Antagonist %Inhib (Mean)

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Translocator protein

External ID: CHEMBL5442260

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5742
ChEMBL Target Name: Translocator protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	34.51	%	Inactive
Inhibition	=	-17.19	%	Inactive	Outside typical range
Inhibition	=	84.71	%	Active
Inhibition	=	36.95	%	Inactive
Inhibition	=	27.53	%	Inactive
Inhibition	=	59.06	%	Active
Inhibition	=	0.37	%	Inactive
Inhibition	=	38.45	%	Inactive
Inhibition	=	31.24	%	Inactive
Inhibition	=	-1.68	%	Inactive
Inhibition	=	30.18	%	Inactive
Inhibition	=	24.43	%	Inactive
Inhibition	=	98.51	%	Active
Inhibition	=	-0.39	%	Inactive
Inhibition	=	76.47	%	Active
Inhibition	=	20.72	%	Inactive
Inhibition	=	2.96	%	Inactive
Inhibition	=	8.35	%	Inactive
Inhibition	=	20.14	%	Inactive
Inhibition	=	53.91	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma intracellular receptor 2

External ID: CHEMBL5442259

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4105907
ChEMBL Target Name: Sigma intracellular receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	3.25	%	Inactive
Inhibition	=	22.06	%	Inactive
Inhibition	=	-0.23	%	Inactive
Inhibition	=	-35.88	%	Inactive	Outside typical range
Inhibition	=	15.44	%	Inactive
Inhibition	=	8.74	%	Inactive
Inhibition	=	10.53	%	Inactive
Inhibition	=	97.54	%	Active
Inhibition	=	98.69	%	Active
Inhibition	=	-15.8	%	Inactive	Outside typical range
Inhibition	=	62.5	%	Active
Inhibition	=	95.44	%	Active
Inhibition	=	90.75	%	Active
Inhibition	=	12.31	%	Inactive
Inhibition	=	63.09	%	Active
Inhibition	=	46.71	%	Inactive
Inhibition	=	17.59	%	Inactive
Inhibition	=	-24.2	%	Inactive	Outside typical range
Inhibition	=	-5.25	%	Inactive
Inhibition	=	-19.3	%	Inactive	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent serotonin transporter

External ID: CHEMBL5442258

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL228
ChEMBL Target Name: Serotonin transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	85.43	%	Active
Inhibition	=	-24.65	%	Inactive	Outside typical range
Inhibition	=	-9.18	%	Inactive
Inhibition	=	-27.85	%	Inactive	Outside typical range
Inhibition	=	-18	%	Inactive	Outside typical range
Inhibition	=	-8.05	%	Inactive
Inhibition	=	-10.45	%	Inactive	Outside typical range
Inhibition	=	48.82	%	Inactive
Inhibition	=	80.75	%	Active
Inhibition	=	-29.9	%	Inactive	Outside typical range
Inhibition	=	-10.09	%	Inactive	Outside typical range
Inhibition	=	41.03	%	Inactive
Inhibition	=	39.04	%	Inactive
Inhibition	=	-41.14	%	Inactive	Outside typical range
Inhibition	=	3.66	%	Inactive
Inhibition	=	13.68	%	Inactive
Inhibition	=	-32.76	%	Inactive	Outside typical range
Inhibition	=	-35.25	%	Inactive	Outside typical range
Inhibition	=	-37.33	%	Inactive	Outside typical range
Inhibition	=	26.5	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peregrin

External ID: CHEMBL5061873

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3132741
ChEMBL Target Name: Peregrin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.2971	C	Thermal Shift Assay
Delta TM	=	0.5753	C	Thermal Shift Assay
Delta TM	=	0.4361	C	Thermal Shift Assay
Delta TM	=	-0.4298	C	Thermal Shift Assay
Delta TM	=	0.02717	C	Thermal Shift Assay
Delta TM	=	-5.472	C	Thermal Shift Assay
Delta TM	=	-1.59	C	Thermal Shift Assay
Delta TM	=	-0.2291	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.3072	C	Thermal Shift Assay
Delta TM	=	-0.02679	C	Thermal Shift Assay
Delta TM	=	-0.8431	C	Thermal Shift Assay
Delta TM	=	-2.387	C	Thermal Shift Assay
Delta TM	=	0.1799	C	Thermal Shift Assay
Delta TM	=	-1.436	C	Thermal Shift Assay
Delta TM	=	-1.017	C	Thermal Shift Assay
Delta TM	=	1.328	C	Thermal Shift Assay
Delta TM	=	1.119	C	Thermal Shift Assay
Delta TM	=	-1.439	C	Thermal Shift Assay
Delta TM	=	-0.7527	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fibroblast

External ID: CHEMBL4725213

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5314315
ChEMBL Target Name: Fibroblast
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	-0.32
Growth Rate	=	-0.85
Growth Rate	=	0.66
Growth Rate	=	0.58
Growth Rate	=	0.86
Growth Rate	=	0.06
Growth Rate	=	0.1
Growth Rate	=	0.63
Growth Rate	=	0.67
Growth Rate	=	0.46
Growth Rate	=	0.87
Growth Rate	=	0
Growth Rate	=	0.46
Growth Rate	=	0.87
Growth Rate	=	-0.42
Growth Rate	=	-0.57
Growth Rate	=	-0.81
Growth Rate	=	0.2
Growth Rate	=	0.77
Growth Rate	=	0.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent dopamine transporter

External ID: CHEMBL5442257

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL238
ChEMBL Target Name: Dopamine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	26.32	%	Inactive
Inhibition	=	29.52	%	Inactive
Inhibition	=	25.75	%	Inactive
Inhibition	=	27.44	%	Inactive
Inhibition	=	44.12	%	Inactive
Inhibition	=	42.07	%	Inactive
Inhibition	=	31.45	%	Inactive
Inhibition	=	21.3	%	Inactive
Inhibition	=	68.93	%	Active
Inhibition	=	32.82	%	Inactive
Inhibition	=	40.02	%	Inactive
Inhibition	=	70.16	%	Active
Inhibition	=	81.11	%	Active
Inhibition	=	32.69	%	Inactive
Inhibition	=	17.48	%	Inactive
Inhibition	=	26.87	%	Inactive
Inhibition	=	35.55	%	Inactive
Inhibition	=	-13.14	%	Inactive	Outside typical range
Inhibition	=	14.1	%	Inactive
Inhibition	=	59.83	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK-293T

External ID: CHEMBL4725212

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3706568
ChEMBL Target Name: HEK-293T
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	0.66
Growth Rate	=	0.47
Growth Rate	=	0.81
Growth Rate	=	0.62
Growth Rate	=	0.92
Growth Rate	=	0.99
Growth Rate	=	-0.15
Growth Rate	=	-0.01
Growth Rate	=	0.69
Growth Rate	=	0.27
Growth Rate	=	0.71
Growth Rate	=	0.38
Growth Rate	=	0.78
Growth Rate	=	0.46
Growth Rate	=	0.9
Growth Rate	=	0.97
Growth Rate	=	0.97
Growth Rate	=	0.5
Growth Rate	=	0.33
Growth Rate	=	0.54

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter

External ID: CHEMBL5442256

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL222
ChEMBL Target Name: Norepinephrine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	83.89	%	Active
Inhibition	=	-9.78	%	Inactive
Inhibition	=	5.56	%	Inactive
Inhibition	=	-32.43	%	Inactive	Outside typical range
Inhibition	=	1.83	%	Inactive
Inhibition	=	28.48	%	Inactive
Inhibition	=	-15.09	%	Inactive	Outside typical range
Inhibition	=	27.12	%	Inactive
Inhibition	=	53.68	%	Active
Inhibition	=	-18.29	%	Inactive	Outside typical range
Inhibition	=	-28.56	%	Inactive	Outside typical range
Inhibition	=	69.21	%	Active
Inhibition	=	59.52	%	Active
Inhibition	=	-28.76	%	Inactive	Outside typical range
Inhibition	=	54.14	%	Active
Inhibition	=	12.97	%	Inactive
Inhibition	=	-2.22	%	Inactive
Inhibition	=	-23.39	%	Inactive	Outside typical range
Inhibition	=	-17.87	%	Inactive	Outside typical range
Inhibition	=	35.61	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1

External ID: CHEMBL5442255

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL287
ChEMBL Target Name: Sigma opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	15.98	%	Inactive
Inhibition	=	29.05	%	Inactive
Inhibition	=	59.9	%	Active
Inhibition	=	6.35	%	Inactive
Inhibition	=	20.78	%	Inactive
Inhibition	=	-31.72	%	Inactive	Outside typical range
Inhibition	=	90.27	%	Active
Inhibition	=	38.72	%	Inactive
Inhibition	=	87.27	%	Active
Inhibition	=	61.39	%	Active
Inhibition	=	48.49	%	Inactive
Inhibition	=	75.19	%	Active
Inhibition	=	92.28	%	Active
Inhibition	=	-25.07	%	Inactive	Outside typical range
Inhibition	=	14.45	%	Inactive
Inhibition	=	87.3	%	Active
Inhibition	=	38.92	%	Inactive
Inhibition	=	-1.8	%	Inactive
Inhibition	=	5.27	%	Inactive
Inhibition	=	9.64	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2OS

External ID: CHEMBL4725214

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL615023
ChEMBL Target Name: U2OS
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	0.94
Growth Rate	=	0.96
Growth Rate	=	0.56
Growth Rate	=	0.78
Growth Rate	=	0.8
Growth Rate	=	0.92
Growth Rate	=	0.78
Growth Rate	=	-0.28
Growth Rate	=	-0.1
Growth Rate	=	0.54
Growth Rate	=	0.58
Growth Rate	=	0.72
Growth Rate	=	0.97
Growth Rate	=	0.76
Growth Rate	=	0.97
Growth Rate	=	0.82
Growth Rate	=	0.75
Growth Rate	=	0.87
Growth Rate	=	0.77
Growth Rate	=	0.78

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mu-type opioid receptor

External ID: CHEMBL5442254

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL233
ChEMBL Target Name: Mu opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	26.73	%	Inactive
Inhibition	=	-15.23	%	Inactive	Outside typical range
Inhibition	=	0.92	%	Inactive
Inhibition	=	-4.54	%	Inactive
Inhibition	=	5.79	%	Inactive
Inhibition	=	5.76	%	Inactive
Inhibition	=	-1.47	%	Inactive
Inhibition	=	16.79	%	Inactive
Inhibition	=	63.49	%	Active
Inhibition	=	8.2	%	Inactive
Inhibition	=	9.53	%	Inactive
Inhibition	=	-2.77	%	Inactive
Inhibition	=	36.32	%	Inactive
Inhibition	=	-2.25	%	Inactive
Inhibition	=	9.06	%	Inactive
Inhibition	=	98.51	%	Active
Inhibition	=	38.81	%	Inactive
Inhibition	=	8.82	%	Inactive
Inhibition	=	-1.77	%	Inactive
Inhibition	=	27.11	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kappa-type opioid receptor

External ID: CHEMBL5442253

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL237
ChEMBL Target Name: Kappa opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	14.68	%	Inactive
Inhibition	=	-13.81	%	Inactive	Outside typical range
Inhibition	=	27.65	%	Inactive
Inhibition	=	9.13	%	Inactive
Inhibition	=	22.52	%	Inactive
Inhibition	=	30.74	%	Inactive
Inhibition	=	3.37	%	Inactive
Inhibition	=	46.94	%	Inactive
Inhibition	=	65.83	%	Active
Inhibition	=	16.93	%	Inactive
Inhibition	=	49.15	%	Inactive
Inhibition	=	-12.49	%	Inactive	Outside typical range
Inhibition	=	21.73	%	Inactive
Inhibition	=	-20.88	%	Inactive	Outside typical range
Inhibition	=	34.63	%	Inactive
Inhibition	=	99.76	%	Active
Inhibition	=	4.22	%	Inactive
Inhibition	=	5.7	%	Inactive
Inhibition	=	-6.29	%	Inactive
Inhibition	=	25.65	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL5442252

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL236
ChEMBL Target Name: Delta opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	8.56	%	Inactive
Inhibition	=	-3.9	%	Inactive
Inhibition	=	-0.59	%	Inactive
Inhibition	=	-16.62	%	Inactive	Outside typical range
Inhibition	=	8.95	%	Inactive
Inhibition	=	13.04	%	Inactive
Inhibition	=	-12.09	%	Inactive	Outside typical range
Inhibition	=	-2.56	%	Inactive
Inhibition	=	17.74	%	Inactive
Inhibition	=	-10.72	%	Inactive	Outside typical range
Inhibition	=	-15.23	%	Inactive	Outside typical range
Inhibition	=	-1.39	%	Inactive
Inhibition	=	37.16	%	Inactive
Inhibition	=	6.63	%	Inactive
Inhibition	=	5.89	%	Inactive
Inhibition	=	99.88	%	Active
Inhibition	=	-19.94	%	Inactive	Outside typical range
Inhibition	=	45.96	%	Inactive
Inhibition	=	-3.58	%	Inactive
Inhibition	=	16.37	%	Inactive

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 7

External ID: CHEMBL5442251

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3155
ChEMBL Target Name: Serotonin 7 (5-HT7) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-26.52	%	Inactive	Outside typical range
Inhibition	=	-7.65	%	Inactive
Inhibition	=	-7.92	%	Inactive
Inhibition	=	12.04	%	Inactive
Inhibition	=	3.26	%	Inactive
Inhibition	=	13.63	%	Inactive
Inhibition	=	-19.59	%	Inactive	Outside typical range
Inhibition	=	37.81	%	Inactive
Inhibition	=	90.25	%	Active
Inhibition	=	-16.5	%	Inactive	Outside typical range
Inhibition	=	-6.37	%	Inactive
Inhibition	=	25.48	%	Inactive
Inhibition	=	-9.84	%	Inactive
Inhibition	=	-8.3	%	Inactive
Inhibition	=	11.4	%	Inactive
Inhibition	=	-19.91	%	Inactive	Outside typical range
Inhibition	=	83.62	%	Active
Inhibition	=	-34.31	%	Inactive	Outside typical range
Inhibition	=	-0.31	%	Inactive
Inhibition	=	-35.56	%	Inactive	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 6

External ID: CHEMBL5442250

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3371
ChEMBL Target Name: Serotonin 6 (5-HT6) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	12.83	%	Inactive
Inhibition	=	-23.76	%	Inactive	Outside typical range
Inhibition	=	-42.14	%	Inactive	Outside typical range
Inhibition	=	-2.9	%	Inactive
Inhibition	=	6.3	%	Inactive
Inhibition	=	25.71	%	Inactive
Inhibition	=	-17.39	%	Inactive	Outside typical range
Inhibition	=	4.75	%	Inactive
Inhibition	=	98.11	%	Active
Inhibition	=	8.17	%	Inactive
Inhibition	=	8.17	%	Inactive
Inhibition	=	-6.79	%	Inactive
Inhibition	=	-0.76	%	Inactive
Inhibition	=	-39.34	%	Inactive	Outside typical range
Inhibition	=	52.27	%	Active
Inhibition	=	5.03	%	Inactive
Inhibition	=	-43.59	%	Inactive	Outside typical range
Inhibition	=	-3.05	%	Inactive
Inhibition	=	-14.82	%	Inactive	Outside typical range
Inhibition	=	-14.96	%	Inactive	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 5A

External ID: CHEMBL5442249

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3426
ChEMBL Target Name: Serotonin 5a (5-HT5a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-11.43	%	Inactive	Outside typical range
Inhibition	=	-17.05	%	Inactive	Outside typical range
Inhibition	=	-43.59	%	Inactive	Outside typical range
Inhibition	=	4.51	%	Inactive
Inhibition	=	-19.97	%	Inactive	Outside typical range
Inhibition	=	-2.34	%	Inactive
Inhibition	=	-12.51	%	Inactive	Outside typical range
Inhibition	=	52.56	%	Active
Inhibition	=	93.97	%	Active
Inhibition	=	8.4	%	Inactive
Inhibition	=	19.68	%	Inactive
Inhibition	=	13.98	%	Inactive
Inhibition	=	4.39	%	Inactive
Inhibition	=	-0.93	%	Inactive
Inhibition	=	60.92	%	Active
Inhibition	=	-17.44	%	Inactive	Outside typical range
Inhibition	=	25.26	%	Inactive
Inhibition	=	-10.39	%	Inactive	Outside typical range
Inhibition	=	-22.5	%	Inactive	Outside typical range
Inhibition	=	-16.06	%	Inactive	Outside typical range

159752-10-0 靶点实验数据