HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL790004

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 22
First Page: 4251
Last Page: 4260
DOI: 10.1021/jm970690q

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MAP	=	34	mmHg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type-1 angiotensin II receptor

External ID: CHEMBL835595

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 13
First Page: 4389
Last Page: 4399
DOI: 10.1021/jm049024x

Target ChEMBL ID: CHEMBL227
ChEMBL Target Name: Type-1 angiotensin II receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0013	Affinity	=	1.3	nM
0.0012	Affinity	=	1.2	nM
4.0E-4	Affinity	=	0.4	nM
1.0E-4	Affinity	~	0.1	nM
0.001	Affinity	~	1	nM
0.0017	Affinity	=	1.7	nM
0.0064	Affinity	=	6.4	nM
0.0013	Affinity	=	1.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL790005

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 22
First Page: 4251
Last Page: 4260
DOI: 10.1021/jm970690q

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MAP	=	67	mmHg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL790839

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 22
First Page: 4251
Last Page: 4260
DOI: 10.1021/jm970690q

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MAP	=	81	mmHg
MAP	=	66	mmHg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type-1 angiotensin II receptor

External ID: CHEMBL650308

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 12
First Page: 2261
Last Page: 2270
DOI: 10.1021/jm0204237

Target ChEMBL ID: CHEMBL227
ChEMBL Target Name: Type-1 angiotensin II receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.044	IC50	=	44	nM
0.044	IC50	=	44	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL839152

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 13
First Page: 4389
Last Page: 4399
DOI: 10.1021/jm049024x

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	7	hr
T1/2	=	6.4	hr
T1/2	=	15	hr
T1/2	=	40	hr
T1/2	=	11	hr
T1/2	=	24	hr
T1/2	=	6.1	hr
T1/2	=	3.2	hr
T1/2	=	21	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL790840

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 22
First Page: 4251
Last Page: 4260
DOI: 10.1021/jm970690q

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MAP	=	76	mmHg
MAP	=	39	mmHg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type-1 angiotensin II receptor

External ID: CHEMBL837510

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 13
First Page: 4389
Last Page: 4399
DOI: 10.1021/jm049024x

Target ChEMBL ID: CHEMBL227
ChEMBL Target Name: Type-1 angiotensin II receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	13	hr
Emax	=	3	hr
Emax	=	0.5	hr
Emax	=	1	hr
Emax	=	1	hr
Emax	=	4	hr
Emax	=	1	hr
Emax	=	2.5	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type-1B angiotensin II receptor

External ID: CHEMBL647794

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 22
First Page: 4251
Last Page: 4260
DOI: 10.1021/jm970690q

Target ChEMBL ID: CHEMBL2094250
ChEMBL Target Name: Angiotensin II receptor (AT-1) type-1
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0065	IC50	=	6.5	nM
0.0023	IC50	=	2.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL637830

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 12
First Page: 2261
Last Page: 2270
DOI: 10.1021/jm0204237

Standard Type	Standard Relation	Standard Value
pKa	=	9.4

159237-67-9 靶点实验数据