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1574495-72-9 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL4649948
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Percent Effect=-0.4113%
Percent Effect=5.918%
Percent Effect=24.74%
Percent Effect=-17.79%
Percent Effect=76.74%
22.7813IC50=22781.31nM
Percent Effect=-1.838%
Percent Effect=13.25%
Percent Effect=8.892%
Percent Effect=-2.138%
Percent Effect=-11.1%
Percent Effect=12.13%
Percent Effect=5.305%
Percent Effect=4.955%
Percent Effect=21.13%
Percent Effect=2.237%
Percent Effect=8.675%
Percent Effect=-6.461%
Percent Effect=-6.594%
Percent Effect=-15.11%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL4649949
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Percent Effect=-3.24%
Percent Effect=-13.31%
Percent Effect=-14.92%
Percent Effect=19.22%
Percent Effect=0.5922%
Percent Effect=5.491%
Percent Effect=16.44%
Percent Effect=-8.493%
Percent Effect=31.52%
Percent Effect=-34.04%
Percent Effect=15.71%
Percent Effect=7.437%
Percent Effect=1.274%
Percent Effect=47.08%
Percent Effect=-6.198%
Percent Effect=34.07%
Percent Effect=24.8%
Percent Effect=26.03%
Percent Effect=-7.513%
Percent Effect=20.66%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:histidine--tRNA ligase
External ID: CHEMBL4649954
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4662925
ChEMBL Target Name: Histidine--tRNA ligase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
Percent Effect=-1.02%
Percent Effect=-0.5917%
Percent Effect=9.091%
Percent Effect=4.95%
Percent Effect=5.752%
Percent Effect=1.639%
Percent Effect=11.88%
Percent Effect=7.955%
Percent Effect=9.278%
Percent Effect=7.772%
Percent Effect=8.537%
Percent Effect=15.61%
Percent Effect=0.7634%
Percent Effect=0.9901%
Percent Effect=2.732%
Percent Effect=10.42%
Percent Effect=4.02%
Percent Effect=1.345%
Percent Effect=2.01%
Percent Effect=-1.754%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:ATP-dependent Clp protease proteolytic subunit 2
External ID: CHEMBL4649972
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4662931
ChEMBL Target Name: ClpP1P2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
Percent Effect=-1.366%
Percent Effect=-5.825%
Percent Effect=-5.631%
Percent Effect=19.16%
Percent Effect=10.17%
Percent Effect=-1.169%
Percent Effect=-5.854%
Percent Effect=-0.3484%
Percent Effect=-1.326%
Percent Effect=3.523%
Percent Effect=-0.9636%
Percent Effect=1.828%
Percent Effect=7.868%
Percent Effect=1.716%
Percent Effect=7.492%
Percent Effect=7.841%
Percent Effect=11.39%
Percent Effect=12.52%
Percent Effect=10.65%
Percent Effect=10.36%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:methionine--tRNA ligase
External ID: CHEMBL3988443
Protocol: N/A
Comment: Target ChEMBL ID: CHEMBL4105741
ChEMBL Target Name: Methionyl-tRNA synthetase, putative
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: Gates Foundation Compound Collection
Standard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Inhibition=12.01%
Inhibition=19.55%
Inhibition=17.71%
Inhibition=16.71%
Inhibition=16.71%
Inhibition=20.2%
Inhibition=16.84%
Inhibition=7.368%
Inhibition=12.02%
Inhibition=15.85%
Inhibition=13.41%
Inhibition=18.87%
Inhibition=4.225%
Inhibition=18.31%
Inhibition=30.14%
Inhibition=11.11%
Inhibition=20.56%
Inhibition=20%
Inhibition=6.667%
Inhibition=15.66%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Coenzyme A biosynthesis bifunctional protein CoaBC
External ID: CHEMBL4649941
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4662928
ChEMBL Target Name: Coenzyme A biosynthesis bifunctional protein CoaBC
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
Percent Effect=11.11%
Percent Effect=-7.632%
30.1995IC50>30199.52nM
30.1995IC50>30199.52nM
Percent Effect=19.9%
Percent Effect=1.314%
Percent Effect=-1.687%
Percent Effect=0%
Percent Effect=12.25%
Percent Effect=4.126%
30.1995IC50>30199.52nM
30.1995IC50>30199.52nM
Percent Effect=-23.7%
Percent Effect=2.913%
Percent Effect=8.949%
Percent Effect=-1.042%
Percent Effect=0%
Percent Effect=-20.66%
Percent Effect=-3.373%
Percent Effect=17.83%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Wolbachia pipientis
External ID: CHEMBL4649973
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4649981
ChEMBL Target Name: Wolbachia pipientis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
Percent Effect=111.15%
Percent Effect=3.966%
Percent Effect=95.89%
Percent Effect=140.64%
Percent Effect=110.99%
Percent Effect=-2.894%
Percent Effect=-3.073%
Percent Effect=87.16%
Percent Effect=-17.79%
Percent Effect=-5.001%
Percent Effect=-2.33%
Percent Effect=-7.382%
Percent Effect=22.93%
Percent Effect=9.484%
Percent Effect=16.07%
Percent Effect=2.64%
Percent Effect=10.61%
Percent Effect=-16.29%
Percent Effect=137.45%
Percent Effect=111.95%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Plasmodium berghei
External ID: CHEMBL4513217
Protocol: N/A
Comment: Journal: ACS Infect Dis
Year: 2020
Volume: 6
Issue: 4
First Page: 613
Last Page: 628
DOI: 10.1021/acsinfecdis.9b00482

Target ChEMBL ID: CHEMBL612653
ChEMBL Target Name: Plasmodium berghei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening
Standard TypeStandard RelationStandard ValueStandard Units
INHIBITION=-1.64%
INHIBITION=-12.28%
INHIBITION=-27.12%
INHIBITION=-25.22%
INHIBITION=1.39%
INHIBITION=52.38%
INHIBITION=42.8%
INHIBITION=33.22%
INHIBITION=45.4%
INHIBITION=53.66%
INHIBITION=8.9%
INHIBITION=-44.94%
INHIBITION=33.4%
INHIBITION=-0.28%
INHIBITION=-14.94%
INHIBITION=6.75%
INHIBITION=23.18%
INHIBITION=-10.41%
INHIBITION=-15.71%
INHIBITION=-24.73%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HepG2
External ID: CHEMBL4513219
Protocol: N/A
Comment: Journal: ACS Infect Dis
Year: 2020
Volume: 6
Issue: 4
First Page: 613
Last Page: 628
DOI: 10.1021/acsinfecdis.9b00482

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening
Standard TypeStandard RelationStandard ValueStandard Units
INHIBITION=4.68%
INHIBITION=-3.78%
INHIBITION=4.68%
INHIBITION=2.51%
INHIBITION=6.68%
INHIBITION=-4.96%
INHIBITION=-1.16%
INHIBITION=7.76%
INHIBITION=6.31%
INHIBITION=-6.48%
INHIBITION=6.18%
INHIBITION=1.98%
INHIBITION=1.83%
INHIBITION=14.6%
INHIBITION=0.995%
INHIBITION=-2.45%
INHIBITION=-127%
INHIBITION=6.33%
INHIBITION=-6.99%
INHIBITION=9.06%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Plasmodium berghei
External ID: CHEMBL4513218
Protocol: N/A
Comment: Journal: ACS Infect Dis
Year: 2020
Volume: 6
Issue: 4
First Page: 613
Last Page: 628
DOI: 10.1021/acsinfecdis.9b00482

Target ChEMBL ID: CHEMBL612653
ChEMBL Target Name: Plasmodium berghei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening
Standard TypeStandard RelationStandard ValueStandard Units
INHIBITION=24.9%
INHIBITION=41.2%
INHIBITION=-15.7%
INHIBITION=50.7%
INHIBITION=49.9%
INHIBITION=54%
INHIBITION=6%
INHIBITION=16.8%
INHIBITION=-5.59%
INHIBITION=18.4%
INHIBITION=13.5%
INHIBITION=15.1%
INHIBITION=48.2%
INHIBITION=6%
INHIBITION=38.3%
INHIBITION=-6.42%
INHIBITION=39.1%
INHIBITION=25.1%
INHIBITION=34.2%
INHIBITION=35.8%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Polyketide synthase Pks13
External ID: CHEMBL4649965
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4105939
ChEMBL Target Name: Polyketide synthase Pks13
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
Percent Effect=-23.46%
Percent Effect=2.907%
Percent Effect=-35.82%
Percent Effect=-0.1445%
Percent Effect=-30.39%
Percent Effect=-7.866%
100IC50>100000nM
Percent Effect=-33.86%
Percent Effect=-1.069%
Percent Effect=-22.74%
Percent Effect=-31.78%
Percent Effect=-39.7%
Percent Effect=3.043%
Percent Effect=-21.69%
Percent Effect=-7.825%
Percent Effect=-5.95%
Percent Effect=4.851%
Percent Effect=-15.5%
Percent Effect=-16.25%
Percent Effect=-15.3%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Plasmodium falciparum
External ID: CHEMBL4513221
Protocol: N/A
Comment: Journal: ACS Infect Dis
Year: 2020
Volume: 6
Issue: 4
First Page: 613
Last Page: 628
DOI: 10.1021/acsinfecdis.9b00482

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening
Standard TypeStandard RelationStandard ValueStandard Units
INHIBITION=1.08%
INHIBITION=1.13%
INHIBITION=1.16%
INHIBITION=1.14%
INHIBITION=1.15%
INHIBITION=1.15%
INHIBITION=1.15%
INHIBITION=1.11%
INHIBITION=1.06%
INHIBITION=1.11%
INHIBITION=1.13%
INHIBITION=1.11%
INHIBITION=1.16%
INHIBITION=1.04%
INHIBITION=1.06%
INHIBITION=1.03%
INHIBITION=1.06%
INHIBITION=1.08%
INHIBITION=1.08%
INHIBITION=1.04%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Plasmodium falciparum
External ID: CHEMBL4513220
Protocol: N/A
Comment: Journal: ACS Infect Dis
Year: 2020
Volume: 6
Issue: 4
First Page: 613
Last Page: 628
DOI: 10.1021/acsinfecdis.9b00482

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening
Standard TypeStandard RelationStandard ValueStandard Units
INHIBITION=-51.2%
INHIBITION=-110%
INHIBITION=2.1%
INHIBITION=-108%
INHIBITION=53.6%
INHIBITION=-104%
INHIBITION=-14.1%
INHIBITION=-98.4%
INHIBITION=-79.6%
INHIBITION=-162%
INHIBITION=-52.4%
INHIBITION=-107%
INHIBITION=-30.2%
INHIBITION=-95.8%
INHIBITION=-155%
INHIBITION=-24.7%
INHIBITION=-167%
INHIBITION=-8.13%
INHIBITION=-45%
INHIBITION=7.06%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3507681
Protocol: N/A
Comment: Data Source: Gates Foundation Compound Collection
Standard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Inhibition=3.51%
Inhibition=-3.904%
Inhibition=-7.749%
Inhibition=-12.82%Outside typical range
Inhibition=-3.395%
Inhibition=-1.449%
Inhibition=-1.105%
Inhibition=-1.625%
Inhibition=4.516%
Inhibition=-2.661%
Inhibition=-1.184%
Inhibition=-12.52%Outside typical range
Inhibition=10.39%
Inhibition=-11.88%Outside typical range
Inhibition=-3.636%
Inhibition=-0.2364%
Inhibition=-5.661%
Inhibition=-6.012%
Inhibition=-6.923%
Inhibition=0.8211%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Tryptophan--tRNA ligase
External ID: CHEMBL4649957
Protocol: N/A
Comment: Target ChEMBL ID: CHEMBL4662922
ChEMBL Target Name: Tryptophan--tRNA ligase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Percent Effect=-0.729%
Percent Effect=0.9507%
Percent Effect=-4.838%
Percent Effect=1.618%
Percent Effect=-0.5913%
Percent Effect=-3.417%
Percent Effect=-0.576%
Percent Effect=-0.7843%
Percent Effect=3.749%
Percent Effect=-5.747%
Percent Effect=-3.118%
Percent Effect=-2.334%
Percent Effect=-0.402%
Percent Effect=-3.288%
Percent Effect=1.06%
Percent Effect=-1.356%
Percent Effect=-0.6056%
Percent Effect=-0.7897%
Percent Effect=1.55%
Percent Effect=-2.716%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:histidine--tRNA ligase
External ID: CHEMBL4649962
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4662927
ChEMBL Target Name: Histidine--tRNA ligase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: Gates Foundation Compound Collection
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
Percent Effect=13.33%
Percent Effect=6.731%
Percent Effect=14.42%
Percent Effect=-1.905%
Percent Effect=21.15%
27.4889IC50=27488.91nM
Percent Effect=4.124%
Percent Effect=0%
Percent Effect=10.31%
Percent Effect=0%
Percent Effect=14.43%
Percent Effect=10.31%
Percent Effect=-6.186%
Percent Effect=-20.62%
Percent Effect=0%
Percent Effect=14.43%
Percent Effect=16.49%
Percent Effect=8.247%
Percent Effect=16.49%
Percent Effect=16.49%