153-87-7 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1

External ID: CHEMBL5291801

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL343
ChEMBL Target Name: GABA receptor alpha-1 subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.0041	AC50	=	4.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.0106	AC50	=	10.6	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2

External ID: CHEMBL5291796

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL5303741
ChEMBL Target Name: Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2000	AC50	>	2000000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")	Outside typical range
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.3	AC50	=	2300	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1

External ID: CHEMBL5291798

Protocol: N/A

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2

External ID: CHEMBL5291797

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL5303741
ChEMBL Target Name: Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
6.8	AC50	=	6800	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
300	AC50	>	300000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")	Outside typical range
12.9999	AC50	=	12999.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endothelin-1 receptor

External ID: CHEMBL5291785

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL252
ChEMBL Target Name: Endothelin receptor ET-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL5291781

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
3.2	AC50	=	3200	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
1.3	AC50	=	1300	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.98	AC50	=	980	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.39	AC50	=	390	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL5291777

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL2056
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cannabinoid receptor 1

External ID: CHEMBL5291772

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL218
ChEMBL Target Name: Cannabinoid CB1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
9.4	AC50	=	9400	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cannabinoid receptor 1

External ID: CHEMBL5291771

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL218
ChEMBL Target Name: Cannabinoid CB1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocortin receptor 3

External ID: CHEMBL5291831

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL4644
ChEMBL Target Name: Melanocortin receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
18.8001	AC50	=	18800.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
27.4101	AC50	=	27410.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuropeptide Y receptor type 1

External ID: CHEMBL5291834

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL4777
ChEMBL Target Name: Neuropeptide Y receptor type 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Motilin receptor

External ID: CHEMBL5291833

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL2203
ChEMBL Target Name: Motilin receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
9.4393	AC50	=	9439.3	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-gated inwardly rectifying potassium channel KCNH2

External ID: CHEMBL5291828

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
350.002	AC50	=	350001.6	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")	Outside typical range
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
4.06	AC50	=	4060	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
9.1	AC50	=	9100	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：DNA polymerase iota [Homo sapiens]

External ID: PolI100

Protocol: Three microliters of reagents (buffer in column 3 and 4 as negative control and 10 nM Pol iota in columns 1, 2, and 5-48) will be dispensed into 1,536-well black solid-bottomed plate. Compounds (23 nL) will be transferred via Kalypsys pin tool equipped with 1536-pin array. The plates will then be incubated for 15 min at room temperature, and 1 muL substrate (50 nM final concentration) will be added to start the reaction and kinetically read twice at 0 min and 10 min on the Viewlux reader.

Comment: Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.447 uM	Activity at 2.333 uM	Activity at 11.29 uM	Activity at 58.90 uM	Activity at 114.8 uM	Compound QC
Activator	100	38.2868	Single point of activity	-4	4.9549	0.9173	40	1.7132	3	0 0 0 0 0	30.0132	5.2309	2.1349	2.7977	-1.489	30.0132	QC'd by "Asinex Ltd."
Activator	100	54.6995	Single point of activity	-4	4.9549	0.9067	56.2988	1.5993	3	0 0 0 0 0	42.8693	6.5044	4.3471	-0.522	-3.4058	42.8693	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-17.2476	21.6169	12.7311	22.8702	20.8427	-17.2476	QC'd by "Asinex Ltd."
Activator	100	74.7794	Single point of activity	-4	4.9549	0.9041	76.0108	1.2314	3	0 0 0 0 0	57.8804	6.7166	3.0104	3.7559	-6.8905	57.8804	QC'd by "Asinex Ltd."
Activator	100	53.1278	Single point of activity	-4	4.9549	0.9205	64.5427	11.4149	3	0 0 0 0 0	51.5124	12.0687	10.6696	16.4441	7.3638	51.5124	QC'd by "Asinex Ltd."
Activator	89.1251	88.3489	Single point of activity	-4.05	4.9549	0.8504	83.4345	-4.9144	3	0 0 0 0 0	66.09	-2.4773	2.699	3.4126	-18.2031	66.09	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	28.3132	7.6044	7.1621	1.8797	-18.6884	28.3132	QC'd by "Asinex Ltd."
Inactive									4	0 0 0	-12.1963	15.5341	6.1257			-12.1963	QC'd by "Asinex Ltd."
Activator	70.7946	131.9739	Single point of activity	-4.15	4.9549	0.9814	124.2791	-7.6948	3	0 0 0 0	113.1868	-14.9551	3.8059	-12.5697		113.1868	QC'd by "Asinex Ltd."
Activator	50.1187	98.8583	Partial curve; high efficacy; poor fit	-4.3	2.8473	0.9993	127.1199	28.2616	2.3	0 0 0	118.3612	29.7145	27.0534			118.3612	QC'd by "Asinex Ltd."
Activator	89.1251	52.8332	Single point of activity	-4.05	4.9549	0.8839	46.5982	-6.2351	3	0 0 0 0 0	35.9582	-5.7785	0.0051	-3.002	-11.6645	35.9582	QC'd by "Asinex Ltd."
Activator	44.6684	58.1237	Single point of activity	-4.35	3.132	1	63.6237	5.5	3	0 0 0	60.693	5.2497	5.4646			60.693	QC'd by "Asinex Ltd."
Activator	100	32	Partial curve; partial efficacy; poor fit	-4	4.9549	0.7933	42	10	2.4	0 0 0 0 0	31.927	6.4109	17.9669	11.7318	10.1379	31.927	QC'd by "Asinex Ltd."
Activator	70.7946	52.3872	Partial curve; partial efficacy; poor fit	-4.15	3.132	0.9366	88.8106	36.4234	2.4	0 0 0	79.2341	43.0009	30.195			79.2341	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	10.1042	-2.0932	-3.6864	-11.1533	-2.2306	10.1042	QC'd by "Asinex Ltd."
Activator	35.4813	94.2201	Single point of activity	-4.45	1.7137	1	103.2201	9	3	1 0 0	91.9965	33.4991	9.8887			91.9965	QC'd by "Asinex Ltd."
Activator	89.1251	188.8272	Single point of activity	-4.05	4.9549	0.9819	184.3761	-4.4511	3	0 0 0 0 0	142.9272	-4.9415	0.8751	3.841	0.2429	142.9272	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	15.1304	-16.5373	-21.4322	-21.4132	-27.9881	15.1304	QC'd by "Asinex Ltd."
Activator	89.1251	54.5907	Single point of activity	-4.05	4.9549	0.8982	43.8763	-10.7143	3	0 0 0 0 0	34.3843	-5.7785	-4.8931	-14.2749	-14.7248	34.3843	QC'd by "Asinex Ltd."
Activator	56.2341	79.3018	Partial curve; high efficacy; poor fit	-4.25	3.132	0.9915	106.1029	26.8011	2.3	0 0 0	98.2435	30.6599	23.0391			98.2435	QC'd by "Asinex Ltd."

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 3A

External ID: CHEMBL5291824

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL1899
ChEMBL Target Name: Serotonin 3a (5-HT3a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.1	AC50	=	2100	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL5291823

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL225
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
6.8	AC50	=	6800	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
5.4	AC50	=	5400	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens]

External ID: PolK100

Protocol: Three microliters of reagents (buffer in column 3 and 4 as negative control and 10 nM Pol kappa in columns 1, 2, and 5-48) were dispensed into a 1536-well black solid-bottom plate. Compounds (23 nL) were transferred via Kalypsys pin tool equipped with 1536-pin array. The plates were then incubated for 15 min at room temperature, and 1 uL substrate (50 nM final concentration) were then added to start the reaction and kinetically read twice at 0 min and 10 min on the Viewlux reader

Phenotype	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.477 uM	Activity at 2.393 uM	Activity at 11.99 uM	Activity at 60.11 uM	Activity at 107.2 uM	Compound QC
Inactive	4	0 0 0 0 0	1.4694	-3.5669	-6.235	2.8586	1.8042	1.4694	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	-4.2631	8.2218	8.0811	10.2927	-3.9947	-4.2631	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	6.0369	0.3398	-2.1048	-8.1695	-3.6822	6.0369	QC'd by "Chem Div"
Inactive	4		-2.0565	1.7294	-3.5894	-1.2575	-0.5402	-2.0565	QC'd by "Chem Div"
Inactive	4	0 0 0 0 1	2.3149	1.0048	4.6369	-1.9963	-3.3543	2.3149	QC'd by "Chem Div"
Inactive	4		7.2748	7.1515	6.1372	1.5197	5.2332	7.2748	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	1.006	-3.3873	-7.786	-9.3037	-9.1761	1.006	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	-0.0368	-9.4458	-10.5155	-9.0065	-12.9141	-0.0368	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	2.6	-7.8084	-12.3007	-2.0954	-6.6887	2.6	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	-11.4867	-18.9051	-17.4955	-19.0735	-9.6682	-11.4867	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	-7.5605	-17.2173	-11.0038	-16.5656	-22.4025	-7.5605	QC'd by "Chem Div"
Inactive	4		-7.5451	-1.1939	-1.3084	-5.8268	-5.3206	-7.5451	QC'd by "Chem Div"
Inactive	4	0 0 0 0 1	-5.5852	-4.3753	-1.0046	-3.1641	-10.1524	-5.5852	QC'd by "Chem Div"
Inactive	4	0 0 0 0 0	1.1172	-6.0391	7.0118	9.0446	1.6533	1.1172	QC'd by "Chem Div"
Inactive	4		2.3359	1.2518	1.6626	-0.9325	-0.9194	2.3359	QC'd by "Chem Div"
Inactive	4	0 0 0 0	-19.5354	0.3984	-4.1147	2.1883	-19.5354		QC'd by "Chem Div"
Inactive	4		-5.6552	-4.6769	-1.9378	-0.5867	-3.224	-5.6552	QC'd by "Chem Div"
Inactive	4		-11.3738	-10.4148	-13.8912	-10.4252	-7.8961	-11.3738	QC'd by "Chem Div"
Inactive	4		-6.1571	-8.7102	-2.9113	-5.2229	-3.4369	-6.1571	QC'd by "Chem Div"
Inactive	4	0 0 0 0 1	-7.3803	-8.8177	-11.1654	-6.5301	-15.9483	-7.3803	QC'd by "Chem Div"

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B

External ID: CHEMBL5291819

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL1833
ChEMBL Target Name: Serotonin 2b (5-HT2b) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B

External ID: CHEMBL5291821

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL1833
ChEMBL Target Name: Serotonin 2b (5-HT2b) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.03	AC50	=	30	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
5	AC50	=	5000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2	AC50	=	2000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
16	AC50	=	16000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
23.0651	AC50	=	23065.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
23.0001	AC50	=	23000.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
20	AC50	=	20000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
5.6	AC50	=	5600	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：N/A

External ID: SMAD3201

Protocol: Suspensions of trypsinized HEPG2 CAGA-GFP cells were dispensed into white, tissue culture-treated, solid 1536-well plates at 5uL/well (1000 cells/well final concentration) in DMEM medium supplemented with 1% FBS. Plates were incubated at 37 degrees C for 2 hours, after which 23 nL of compounds or DMSO were delivered to each well using a pin tool. One uL of recombinant TGF-beta in DMEM (1% FBS) was then dispensed (500 pg/mL final concentration), and plates were incubated at 37 degrees C for 18 hours. Two uL of CellTiter Glo (Promega), a luminescence-based viability reagent, was dispensed, followed by a 10 minute room temperature incubation. The plates were then measured on a PerkinElmer ViewLux plate reader for luminescence (clear filter) using a 5 second exposure. The %Activity was determined from the corrected luminescence values. Wells containing media only (no cells) were used to normalize %Activity of identified toxic compounds; media-only wells corresponded to 100%Activity (complete cell-killing), while DMSO-dosed cell controls were used to normalize 0%Activity (no toxicity).

Concentration-response curves were fitted to the signals arising from the resulting luminescence. The concentration-effect curves were then classified based on curve quality (r2), response magnitude and degree of measured activity, and compounds were subsequently categorized based on their curve class. Toxic compounds showed concentration-dependent decreases in luminescence, concordant with a decrease in intracellular ATP concentration (CellTiter Glo's marker of viability), and thus a decrease in the number of viable cells. Inactive (non-toxic) compounds showed no effect on luminescence signal. Active (toxic) compounds showed concentration dependent decrease in luminescence.

Comment: Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description".

2. For all inactive (non-toxic) compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active (toxic) compounds, a score range was given for each curve class type given above. Active (toxic) compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.074 uM	Activity at 0.369 uM	Activity at 1.840 uM	Activity at 9.233 uM	Activity at 46.10 uM	Compound QC
Inactive									4	0 0 0 0 0	0.2596	10.769	4.1255	-1.6909	-0.7487	0.2596	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-0.8876	-5.2018	-3.6707	0.3303	2.9155	-0.8876	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-4.2306	-10.0984	-0.7957	-0.9322	2.0609	-4.2306	QC'd by "Chem Div"
Inactive									4		5.8218	-1.6618	-3.0553	9.7773	-4.173	5.8218	QC'd by "Chem Div"
Inactive									4		-3.2651	11.605	-17.8848	5.9785	14.3087	-3.2651	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-7.241	3.2008	3.9728	-4.5121	3.9811	-7.241	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-9.807	8.9869	0.3484	0.3728	7.0197	-9.807	QC'd by "Chem Div"
Cytotoxic	17.7828	35.5846	Partial curve; partial efficacy	-4.75	2.3031	0.9974	-42.6167	-7.0321	-2.2	0 0 0 0 0	-39.1036	-6.2767	-6.4175	-8.2439	-13.6777	-39.1036	QC'd by "Chem Div"
Cytotoxic	3.5481	40.0619	Single point of activity	-5.45	4.9549	0.8999	-40.3659	-0.3039	-3	0 0 0 0 1	2.6367	-8.333	7.8061	-1.7484	-40.2332	2.6367	QC'd by "Chem Div"
Inactive									4	0 0 0 0 1	0.5424	1.6591	9.6647	14.2749	15.5896	0.5424	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	5.9628	-8.298	-2.3104	6.1361	-3.4428	5.9628	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-1.0151	-4.6247	-5.8885	-4.492	-0.7127	-1.0151	QC'd by "Chem Div"
Inactive									4		-0.9022	-1.2889	13.9053	-1.079	4.3101	-0.9022	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-23.5202	-1.5751	7.1469	-12.6721	9.6037	-23.5202	QC'd by "Chem Div"
Inactive									4	0 0 0 0 1	-0.075	-0.6173	-0.8732	5.135	2.1913	-0.075	QC'd by "Chem Div"
Cytotoxic	35.4813	33.3813	Single point of activity	-4.45	4.9549	0.4913	-37.3813	-4	-3	0 0 0 0 0	-30.3178	-0.6381	-23.6633	-3.8386	6.0591	-30.3178	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-17.414	0.1464	-4.8771	-5.0687	-7.6162	-17.414	QC'd by "Chem Div"
Inactive									4		-4.6673	-7.1501	-3.3264	-4.1232	-3.249	-4.6673	QC'd by "Chem Div"
Inactive									4	0 0 0 0 0	-17.3878	6.5726	2.9374	-7.8375	-3.1433	-17.3878	QC'd by "Chem Div"
Inactive									4	0 0 0 0 1	-10.2269	-7.0609	-5.5812	-5.8217	2.0518	-10.2269	QC'd by "Chem Div"

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL5291816

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL5291817

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.07	AC50	=	70	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	=	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.8	AC50	=	2800	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
17.9999	AC50	=	17999.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.9	AC50	=	900	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL5291814

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
6.9	AC50	=	6900	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
4.8	AC50	=	4800	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL5291813

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
4.4	AC50	=	4400	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL5291808

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL231
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
1.8974	AC50	=	1897.4	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
1.2	AC50	=	1200	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.5914	AC50	=	591.4	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.056	AC50	=	56	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL5291807

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL231
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
7.1	AC50	=	7100	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H2 receptor

External ID: CHEMBL5291810

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL1941
ChEMBL Target Name: Histamine H2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL5291809

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL231
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
15	AC50	=	15000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
1	AC50	>	1000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Growth hormone secretagogue receptor type 1

External ID: CHEMBL5291803

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL4616
ChEMBL Target Name: Ghrelin receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.2	AC50	=	2200	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
22.1998	AC50	=	22199.8	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
18.9998	AC50	=	18999.8	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：Smad3 [Homo sapiens]

External ID: SMAD3101

Protocol: Suspensions of trypsinized HEPG2 CAGA-GFP cells were dispensed into white, tissue culture-treated, solid 1536-well plates at 5uL/well (1000 cells/well final concentration) in DMEM medium supplemented with 1% FBS. Plates were incubated at 37 degrees C for 2 hours, after which 23 nL of compounds or DMSO were delivered to each well using a pin tool. One uL of recombinant TGF-beta in DMEM (1% FBS) was then dispensed (500 pg/mL final concentration), and plates were incubated at 37 degrees C for 18 hours. The plates were measured on an Acumen eX3 Explorer plate reader for GFP fluorescence (ex488/em500-530). GFP values were calculated by determining the mean GFP fluorescence of individual cells, and compiling these values for each well to determine a total well GFP signal. The %Activity was determined from the corrected fluorescence values. A titration of the known TGF-B inhibitor SB431542 was included to monitor plate performance, while unstimulated HEPG2 (-TGF-B) control wells were used to normalize %Activity of identified inhibitors; unstimulated wells corresponded to 100%Activity (full inhibition), while stimulated cell controls (+DMSO) were used to normalize 0%Activity (no inhibition).

Concentration-response curves were fitted to the signals arising from the resulting fluorescence. The concentration-effect curves were then classified based on curve quality (r2), response magnitude and degree of measured activity, and compounds were subsequently categorized based on their curve class. Active inhibitors showed concentration-dependent decreases in GFP fluorescence, concordant with a decrease in TGF-B/SMAD3-driven GFP expression. Inactive compounds showed no effect on fluorescence signal.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.074 uM	Activity at 0.369 uM	Activity at 1.840 uM	Activity at 9.231 uM	Activity at 46.10 uM	Compound QC
Inactive									4	0 0 0 0 0	27.0569	9.9398	10.1515	0.1671	5.5721	27.0569	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 1	-4.9362	-9.414	12.0824	-11.0493	-7.696	-4.9362	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 1	5.9595	4.342	-1.5624	-2.6449	-8.9538	5.9595	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-19.7473	-1.448	7.5701	-38.1554	-17.3097	-19.7473	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-1.2351	-5.5487	-5.0573	-16.6211	2.7653	-1.2351	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	7.1959	-7.7682	4.4899	3.3992	13.3707	7.1959	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 1	8.9833	15.335	4.2535	4.1946	-14.3236	8.9833	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	7.9022	-10.5174	13.4936	-10.4686	7.2323	7.9022	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-11.8347	12.2839	-2.7256	-19.2666	-5.8034	-11.8347	QC'd by "Asinex Ltd."
Inhibitor	35.4813	106.2444	Single point of activity	-4.45	4.4495	0.9934	-109.7251	-3.4808	-3	0 0 0 0 0	-84.6645	-7.4849	-2.0755	-4.8114	0.1432	-84.6645	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-3.6	-2.0717	4.9414	15.4055	-0.2463	-3.6	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	0.7641	0	28.3456	12.1698	0.9078	0.7641	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 1	-3.7338	-9.9559	0.3986	8.9255	12.5033	-3.7338	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-1.7797	3.883	1.182	-4.185	1.7497	-1.7797	QC'd by "Asinex Ltd."
Inhibitor	15.8489	38.9608	Single point of activity	-4.8	3.6772	0.9889	-35.4608	3.5	-3	0 0 0 0 0	-32.884	2.0677	5.819	2.7318	-1.3119	-32.884	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-3.797	8.4821	-2.1836	12.76	5.4907	-3.797	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	-18.7499	1.0272	3.815	20.5199	1.7606	-18.7499	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	0.464	0	9.4101	-6.5206	0.9067	0.464	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 0	0.2371	9.7122	-4.6112	-6.6419	-3.2889	0.2371	QC'd by "Asinex Ltd."
Inactive									4	0 0 0 0 1	3.6799	4.8924	1.7621	-1.6686	-4.4945	3.6799	QC'd by "Asinex Ltd."

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 1

External ID: CHEMBL5291805

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL330
ChEMBL Target Name: Glutamate (NMDA) receptor subunit zeta 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Progesterone receptor

External ID: CHEMBL5291860

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL208
ChEMBL Target Name: Progesterone receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Progesterone receptor

External ID: CHEMBL5291861

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL208
ChEMBL Target Name: Progesterone receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	=	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.3	AC50	>	300	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
320	AC50	=	320000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：3',5'-cyclic-AMP phosphodiesterase 4D

External ID: CHEMBL5291858

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL288
ChEMBL Target Name: Phosphodiesterase 4D
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.8844	AC50	=	2884.4	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
4.4	AC50	=	4400	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
17.9999	AC50	=	17999.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL5291852

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL236
ChEMBL Target Name: Delta opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mu-type opioid receptor

External ID: CHEMBL5291854

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL233
ChEMBL Target Name: Mu opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
28.0001	AC50	=	28000.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kappa-type opioid receptor

External ID: CHEMBL5291853

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL237
ChEMBL Target Name: Kappa opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.4133	AC50	=	413.3	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.6099	AC50	=	2609.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
17.9999	AC50	=	17999.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
2.2429	AC50	=	2242.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
7.5	AC50	=	7500	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
4.1062	AC50	=	4106.2	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucocorticoid receptor

External ID: CHEMBL5291850

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL2034
ChEMBL Target Name: Glucocorticoid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.0017	AC50	=	1.7	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2

External ID: CHEMBL5291844

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL3401
ChEMBL Target Name: Pregnane X receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
26.9998	AC50	=	26999.8	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2

External ID: CHEMBL5291846

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL3401
ChEMBL Target Name: Pregnane X receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
13.4304	AC50	=	13430.4	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2

External ID: CHEMBL5291845

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL3401
ChEMBL Target Name: Pregnane X receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
1	AC50	>	1000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A

External ID: CHEMBL5291895

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL1951
ChEMBL Target Name: Monoamine oxidase A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
5.6	AC50	=	5600	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

External ID: CHEMBL5291898

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL241
ChEMBL Target Name: Phosphodiesterase 3A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
6.1871	AC50	=	6187.1	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent serotonin transporter

External ID: CHEMBL5291892

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL228
ChEMBL Target Name: Serotonin transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.018	AC50	=	18	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
11.5239	AC50	=	11523.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
6.8	AC50	=	6800	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.01	AC50	=	10	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter

External ID: CHEMBL5291891

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL222
ChEMBL Target Name: Norepinephrine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
8.84	AC50	=	8840	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.27	AC50	=	270	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.083	AC50	=	83	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
15	AC50	=	15000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
29.9999	AC50	=	29999.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
18.6999	AC50	=	18699.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
0.6	AC50	=	600	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent dopamine transporter

External ID: CHEMBL5291890

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL238
ChEMBL Target Name: Dopamine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
23.6922	AC50	=	23692.2	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
13.8218	AC50	=	13821.8	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
19.5959	AC50	=	19595.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
14.6299	AC50	=	14629.9	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thromboxane A2 receptor

External ID: CHEMBL5291889

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Nat Commun
Year: 2023
Volume: 14
Issue: 1
First Page: 1
Last Page: 17
DOI: 10.1038/s41467-023-40064-9

Target ChEMBL ID: CHEMBL2069
ChEMBL Target Name: Thromboxane A2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
20.064	AC50	=	20064	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
15.3402	AC50	=	15340.2	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
30	AC50	>	30000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")
10	AC50	>	10000	nM	Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">")

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3137722

Protocol: N/A

Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Activity Comment
Hepatotoxicity (moderate)	=	0	references out of a total of 1
Hepatotoxicity (moderate)	=	61	references out of a total of 69
Hepatotoxicity (moderate)	=	2	references out of a total of 5
Hepatotoxicity (moderate)	=	7	references out of a total of 27
Hepatotoxicity (moderate)	=	13	references out of a total of 13
Hepatotoxicity (moderate)	=	1	references out of a total of 1
Hepatotoxicity (moderate)	=	114	references out of a total of 132
Hepatotoxicity (moderate)	=	15	references out of a total of 23
Hepatotoxicity (moderate)	=	1	references out of a total of 1
Hepatotoxicity (moderate)	=	3	references out of a total of 9
Hepatotoxicity (moderate)	=	4	references out of a total of 34
Hepatotoxicity (moderate)	=	1	references out of a total of 5
Hepatotoxicity (moderate)	=	18	references out of a total of 53
Hepatotoxicity (moderate)	=	1	references out of a total of 1
Hepatotoxicity (moderate)	=	1	references out of a total of 14
Hepatotoxicity (moderate)	=	3	references out of a total of 5
Hepatotoxicity (moderate)	=	3	references out of a total of 3
Hepatotoxicity (moderate)	=	3	references out of a total of 16
Hepatotoxicity (moderate)	=	29	references out of a total of 123
Hepatotoxicity (moderate)	=	1	references out of a total of 4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3137723

Protocol: N/A

Standard Type	Standard Relation	Standard Value	Standard Units
Hepatotoxicity (moderate)	=	0	%
Hepatotoxicity (moderate)	=	42.2	%
Hepatotoxicity (moderate)	=	0	%
Hepatotoxicity (moderate)	=	25	%
Hepatotoxicity (moderate)	=	8.3	%
Hepatotoxicity (moderate)	=	5	%
Hepatotoxicity (moderate)	=	46.4	%
Hepatotoxicity (moderate)	=	7.7	%
Hepatotoxicity (moderate)	=	0	%
Hepatotoxicity (moderate)	=	26	%
Hepatotoxicity (moderate)	=	22	%
Hepatotoxicity (moderate)	=	0	%
Hepatotoxicity (moderate)	=	5.8	%
Hepatotoxicity (moderate)	=	6	%
Hepatotoxicity (moderate)	=	7.1	%
Hepatotoxicity (moderate)	=	32	%
Hepatotoxicity (moderate)	=	12.8	%
Hepatotoxicity (moderate)	=	19	%
Hepatotoxicity (moderate)	=	90	%
Hepatotoxicity (moderate)	=	37	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3137724

Protocol: N/A

Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Standard Type	Standard Relation	Standard Value	Activity Comment
Hepatotoxicity (acute)	=	1	references out of a total of 1
Hepatotoxicity (acute)	=	11	references out of a total of 69
Hepatotoxicity (acute)	=	3	references out of a total of 5
Hepatotoxicity (acute)	=	17	references out of a total of 27
Hepatotoxicity (acute)	=	0	references out of a total of 13
Hepatotoxicity (acute)	=	1	references out of a total of 1
Hepatotoxicity (acute)	=	21	references out of a total of 132
Hepatotoxicity (acute)	=	9	references out of a total of 23
Hepatotoxicity (acute)	=	1	references out of a total of 1
Hepatotoxicity (acute)	=	5	references out of a total of 9
Hepatotoxicity (acute)	=	27	references out of a total of 34
Hepatotoxicity (acute)	=	4	references out of a total of 5
Hepatotoxicity (acute)	=	36	references out of a total of 53
Hepatotoxicity (acute)	=	1	references out of a total of 1
Hepatotoxicity (acute)	=	12	references out of a total of 14
Hepatotoxicity (acute)	=	1	references out of a total of 5
Hepatotoxicity (acute)	=	0	references out of a total of 3
Hepatotoxicity (acute)	=	5	references out of a total of 16
Hepatotoxicity (acute)	=	84	references out of a total of 123
Hepatotoxicity (acute)	=	0	references out of a total of 4