HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL619924

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 24
First Page: 3904
Last Page: 3909
DOI: 10.1021/jm00076a019

Target ChEMBL ID: CHEMBL312
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.2	IC50	=	200	nM
0.1	IC50	=	100	nM
43	IC50	=	43000	nM
0.0069	IC50	=	6.9	nM
400	IC50	=	400000	nM	Outside typical range
0.21	IC50	=	210	nM
0.022	IC50	=	22	nM
0.092	IC50	=	92	nM
8.9	IC50	=	8900	nM
0.0085	IC50	=	8.5	nM
0.023	IC50	=	23	nM
0.023	IC50	=	23	nM
0.011	IC50	=	11	nM
0.004	IC50	=	4	nM
0.0053	IC50	=	5.3	nM
0.01	IC50	=	10	nM
35	IC50	=	35000	nM
140	IC50	=	140000	nM	Outside typical range
0.009	IC50	=	9	nM
0.041	IC50	=	41	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL741495

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 24
First Page: 3904
Last Page: 3909
DOI: 10.1021/jm00076a019

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	24.6	%
Inhibition	=	67	%
Inhibition	=	77	%
Inhibition	=	56	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL763066

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 24
First Page: 3904
Last Page: 3909
DOI: 10.1021/jm00076a019

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
460	IC50	=	460000	nM	Outside typical range
19	IC50	=	19000	nM
24	IC50	=	24000	nM
280	IC50	=	280000	nM	Outside typical range
34	IC50	=	34000	nM
2	IC50	=	2000	nM
60	IC50	=	60000	nM
230	IC50	=	230000	nM	Outside typical range
37	IC50	=	37000	nM
130	IC50	=	130000	nM	Outside typical range
65	IC50	=	65000	nM
41	IC50	=	41000	nM
15	IC50	=	15000	nM
140	IC50	=	140000	nM	Outside typical range
44	IC50	=	44000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1073576

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 3
First Page: 1013
Last Page: 1018
DOI: 10.1016/j.bmcl.2009.12.047

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3	IC50	=	3000	nM
8.5	IC50	=	8500	nM
8	IC50	=	8000	nM
10	IC50	=	10000	nM
4	IC50	=	4000	nM
0.77	IC50	=	770	nM
1.6	IC50	=	1600	nM
0.01	IC50	=	10	nM
2.7	IC50	=	2700	nM
14	IC50	=	14000	nM
1	IC50	=	1000	nM
0.85	IC50	=	850	nM
10	IC50	=	10000	nM
3.3	IC50	=	3300	nM
10	IC50	=	10000	nM

152809-87-5 靶点实验数据