HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789871

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	25	ug
Activity	=	25	ug
Activity	=	22	ug
Activity	=	2.5	ug
Activity	=	25	ug
Activity	=	6	ug
Activity	=	2.5	ug
Activity	=	5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789869

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789868

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Activity Comment
FC	=	1.5
FC	=	1.5
FC	=	1.5
FC			Not Active
FC	=	1.5
FC	=	1.5
FC			Not Active
FC	=	1.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789872

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	3.5	ug
Activity	=	3.5	ug
Activity	=	3.5	ug
Activity	=	2.5	ug
Activity	=	3.5	ug
Activity	=	3.5	ug
Activity	=	2.5	ug
Activity	=	3.5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL936122

Protocol: N/A

Comment: Journal: J Biol Chem
Year: 2007
Volume: 282
Issue: 14
First Page: 10311
Last Page: 10324
DOI: 10.1074/jbc.m608207200

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL936124

Protocol: N/A

Comment: Journal: J Biol Chem
Year: 2007
Volume: 282
Issue: 14
First Page: 10311
Last Page: 10324
DOI: 10.1074/jbc.m608207200

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	209	%	Outside typical range
Inhibition	=	-13	%	Outside typical range
Inhibition	=	0.8	%
Inhibition	=	-4.5	%
Inhibition	=	89	%
Inhibition	=	6.4	%
Inhibition	=	0.9	%
Inhibition	=	1.1	%
Inhibition	=	2.9	%
Inhibition	=	0.3	%
Inhibition	=	3.9	%
Inhibition	=	2.5	%
Inhibition	=	1.4	%
Inhibition	=	126	%
Inhibition	=	68	%
Inhibition	=	13	%
Inhibition	=	0.7	%
Inhibition	=	132	%
Inhibition	=	26	%
Inhibition	=	0.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL936125

Protocol: N/A

Comment: Journal: J Biol Chem
Year: 2007
Volume: 282
Issue: 14
First Page: 10311
Last Page: 10324
DOI: 10.1074/jbc.m608207200

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Active
Activity				Active
Activity				Not Active
Activity				Not Active
Activity				Active
Activity				Not Active
Activity				Not Active
Activity				Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Active
Activity				Not Active
Activity				Active
Activity				Active
Activity				Active
Activity				Not Active
Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL936123

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Biol Chem
Year: 2007
Volume: 282
Issue: 14
First Page: 10311
Last Page: 10324
DOI: 10.1074/jbc.m608207200

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
26.06	IC50	=	26060	nM
2.58	IC50	=	2580	nM
67.6	IC50	=	67600	nM
11.48	IC50	=	11480	nM
106.87	IC50	=	106870	nM	Outside typical range
10	IC50	=	10000	nM
361.11	IC50	=	361110	nM	Outside typical range
244.16	IC50	=	244160	nM	Outside typical range
122.19	IC50	=	122190	nM	Outside typical range
31.64	IC50	=	31640	nM
426.25	IC50	=	426250	nM	Outside typical range
0.25	IC50	=	250	nM
2787	IC50	=	2787000	nM	Outside typical range
0.12	IC50	=	120	nM
0.09	IC50	=	90	nM
7.48	IC50	=	7480	nM
0.83	IC50	=	830	nM
25.51	IC50	=	25510	nM
1.87	IC50	=	1870	nM
15.94	IC50	=	15940	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789855

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789854

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MHC	=	10	ug
MHC	=	50	ug
MHC	=	15	ug
MHC	=	20	ug
MHC	=	20	ug
MHC	=	10	ug
MHC				Not Active
MHC	=	10	ug
MHC	=	15	ug
MHC	=	10	ug
MHC	=	25	ug
MHC	=	30	ug
MHC				Not Active
MHC	=	50	ug
MHC	=	15	ug
MHC				Not Active
MHC	=	60	ug
MHC	=	30	ug
MHC	=	50	ug
MHC	=	10	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789853

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789852

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	9	ug
LD50	=	3	ug
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50	=	3	ug
LD50	=	3	ug
LD50	=	3	ug
LD50	=	6	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL631694

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1121
Last Page: 1126
DOI: 10.1021/jm00390a002

Standard Type	Standard Relation	Standard Value
LogP	=	2.26
LogP	=	0.64
LogP	=	1.71
LogP	=	2.1
LogP	=	0.97
LogP	=	1.37
LogP	=	0.65
LogP	=	1.35
LogP	=	0.59
LogP	=	2.7
LogP	=	0.9
LogP	=	-0.17
LogP	=	0.65
LogP	=	0.57
LogP	=	0.73
LogP	=	0.18
LogP	=	0.22
LogP	=	0.74
LogP	=	0.92
LogP	=	1.21

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789859

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	8	ug
LD50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL631695

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1121
Last Page: 1126
DOI: 10.1021/jm00390a002

Standard Type	Standard Relation	Standard Value
LogP	=	0.5
LogP	=	-0.71
LogP	=	-0.01
LogP	=	0.74
LogP	=	0.74
LogP	=	1.87
LogP	=	-0.11
LogP	=	-0.55
LogP	=	0.15
LogP	=	1.74
LogP	=	1
LogP	=	-2.26
LogP	=	0.41
LogP	=	-0.05
LogP	=	1.01
LogP	=	0.53
LogP	=	-1.6
LogP	=	-0.08
LogP	=	-1.4
LogP	=	0.82

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789858

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	3.75
FC	=	1.25
FC	=	3.75
FC	=	2.5
FC	=	3.75
FC	=	1.25
FC	=	3.75
FC	=	1.25
FC	=	1.25
FC	=	2.5
FC	=	2.5
FC	=	1.25
FC	=	2.5
FC	=	2.5
FC	=	2.5
FC	=	3.75
FC	=	3.75
FC	=	1.25
FC	=	2.5
FC	=	3.75

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL875968

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1121
Last Page: 1126
DOI: 10.1021/jm00390a002

Standard Type	Standard Relation	Standard Value
LogP	=	0
LogP	=	-1.54
LogP	=	-0.63
LogP	=	-0.03
LogP	=	0.04
LogP	=	1.4
LogP	=	-0.32
LogP	=	-1.7
LogP	=	0.04
LogP	=	0.99
LogP	=	0.6
LogP	=	-2.45
LogP	=	0.23
LogP	=	0.03
LogP	=	0.95
LogP	=	0.32
LogP	=	-2.56
LogP	=	-0.04
LogP	=	-2.31
LogP	=	0.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_6134_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.034	34	O75460	BDBM110972	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.079	79	O75460	BDBM110973	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.08	80	O75460	BDBM110974	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.1	100	O75460	BDBM110975	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.08	80	O75460	BDBM110975	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.11	110	O75460	BDBM110976	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.12	120	O75460	BDBM110977	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.17	170	O75460	BDBM110978	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.102	102	O75460	BDBM110979	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.102	102	O75460	BDBM110979	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.24	240	O75460	BDBM110980	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.24	240	O75460	BDBM110981	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.25	250	O75460	BDBM110982	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.27	270	O75460	BDBM110983	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.022	22	O75460	BDBM110983	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.28	280	O75460	BDBM110984	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.3	300	O75460	BDBM110985	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.772	772	O75460	BDBM110985	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.35	350	O75460	BDBM110986	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.38	380	O75460	BDBM110987	Serine/threonine-protein kinase/endoribonuclease IRE1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789857

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	150	ug
LD50	=	50	ug
LD50				Not Active
LD50	=	150	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	100	ug
LD50				Not Active
LD50				Not Active
LD50	=	150	ug
LD50	=	50	ug
LD50	=	150	ug
LD50				Not Active
LD50				Not Active
LD50	=	50	ug
LD50	=	50	ug
LD50	=	100	ug
LD50	=	100	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632430

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1121
Last Page: 1126
DOI: 10.1021/jm00390a002

Standard Type	Standard Relation	Standard Value
LogP	=	0.58
LogP	=	0.11
LogP	=	0.62
LogP	=	1.38
LogP	=	1.18
LogP	=	2.3
LogP	=	0.34
LogP	=	-0.12
LogP	=	0.23
LogP	=	1.74
LogP	=	1.42
LogP	=	-1.6
LogP	=	1.43
LogP	=	0.81
LogP	=	1.8
LogP	=	1.16
LogP	=	-1.92
LogP	=	0.56
LogP	=	-0.89
LogP	=	1.42

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789856

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
LogP	=	1.24
LogP	=	0.97
LogP	=	2.39
LogP	=	1.15
LogP	=	1.48
LogP	=	1.87
LogP	=	1.76
LogP	=	1.47
LogP	=	1.44
LogP	=	1.15
LogP	=	1.48
LogP	=	1.48
LogP	=	1.47
LogP	=	3.19
LogP	=	1.19
LogP	=	1.47
LogP	=	2
LogP	=	1.15
LogP	=	1.19
LogP	=	1.15

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632431

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1121
Last Page: 1126
DOI: 10.1021/jm00390a002

Standard Type	Standard Relation	Standard Value
LogP	=	2.37
LogP	=	-0.22
LogP	=	1.51
LogP	=	1.28
LogP	=	0.82
LogP	=	1.35
LogP	=	0.53
LogP	=	1.1
LogP	=	0.38
LogP	=	1.77
LogP	=	0.85
LogP	=	-0.34
LogP	=	0.08
LogP	=	-0.07
LogP	=	0.93
LogP	=	0.43
LogP	=	0.37
LogP	=	0.11
LogP	=	1.31
LogP	=	0.96

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789863

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632432

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1121
Last Page: 1126
DOI: 10.1021/jm00390a002

Standard Type	Standard Relation	Standard Value
LogP	=	-0.57
LogP	=	-2.3
LogP	=	-2.22
LogP	=	-1.3
LogP	=	-0.85
LogP	=	0.53
LogP	=	-0.6
LogP	=	-0.95
LogP	=	0.05
LogP	=	0.3
LogP	=	-0.3
LogP	=	-3.06
LogP	=	-0.21
LogP	=	-0.48
LogP	=	0.29
LogP	=	-0.26
LogP	=	-3.14
LogP	=	-0.62
LogP	=	-2.72
LogP	=	-0.72

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789862

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789861

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MHC	=	10	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	5	ug
MHC	=	5	ug
MHC				Not Active
MHC	=	5	ug
MHC	=	5	ug
MHC	=	10	ug
MHC	=	15	ug
MHC	=	5	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	5	ug
MHC				Not Active
MHC	=	20	ug
MHC	=	15	ug
MHC	=	5	ug
MHC	=	5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789860

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1.6
FC	=	1.6
FC	=	2
FC	=	1.6
FC	=	2
FC	=	2
FC	=	2
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789867

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Activity Comment
FC	=	10
FC	=	10
FC	=	8.8
FC			Not Active
FC	=	10
FC	=	2.4
FC			Not Active
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789866

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789865

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%
Activity	=	10	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789864

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%
Activity	=	40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL891104

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 5
First Page: 2006
Last Page: 2015
DOI: 10.1016/j.bmc.2006.12.038

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
39810700	IC50	=	3.981071705535E10	nM	Outside typical range
5750	IC50	=	5750000	nM	Outside typical range
173780000	IC50	=	1.7378008287494E11	nM	Outside typical range
3120	IC50	=	3120000	nM	Outside typical range
323594000	IC50	=	3.2359365692963E11	nM	Outside typical range
50500	IC50	=	50500000	nM	Outside typical range
19952600	IC50	=	1.995262314969E10	nM	Outside typical range
14200	IC50	=	14200000	nM	Outside typical range
70794600	IC50	=	7.079457843841E10	nM	Outside typical range
16250	IC50	=	16250000	nM	Outside typical range
61659500	IC50	=	6.165950018615E10	nM	Outside typical range
5900	IC50	=	5900000	nM	Outside typical range
169824000	IC50	=	1.6982436524617E11	nM	Outside typical range
5550	IC50	=	5550000	nM	Outside typical range
181970000	IC50	=	181970085861	nM	Outside typical range
42880	IC50	=	42880000	nM	Outside typical range
23442300	IC50	=	2.34422881532E10	nM	Outside typical range
13300	IC50	=	13300000	nM	Outside typical range
75857800	IC50	=	7.585775750292E10	nM	Outside typical range
29500	IC50	=	29500000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789851

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	11.2
FC	=	2.6
FC	=	9.8
FC	=	11.2
FC	=	9.8
FC	=	9.8
FC	=	2.6
FC	=	2.6
FC	=	2.6
FC	=	8
FC	=	2.1
FC	=	9.8
FC	=	2.1
FC	=	4.9
FC	=	4.9
FC	=	11.2
FC	=	8
FC	=	2.6
FC	=	8
FC	=	9.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789850

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	25	ug
LD50	=	6	ug
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	25	ug
LD50				Not Active
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50				Not Active
LD50	=	6	ug
LD50	=	6	ug
LD50	=	6	ug
LD50	=	18	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_3284_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.04	40	O75460	BDBM110972	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.08	80	O75460	BDBM110974	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.1	100	O75460	BDBM110975	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.11	110	O75460	BDBM110976	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.17	170	O75460	BDBM110978	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.24	240	O75460	BDBM110980	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.24	240	O75460	BDBM110981	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.25	250	O75460	BDBM110982	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.27	270	O75460	BDBM110983	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.3	300	O75460	BDBM110985	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.35	350	O75460	BDBM110986	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.38	380	O75460	BDBM110987	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.38	380	O75460	BDBM110988	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.39	390	O75460	BDBM110989	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.4	400	O75460	BDBM110990	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.4	400	O75460	BDBM110991	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.4	400	O75460	BDBM110992	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.41	410	O75460	BDBM110993	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.44	440	O75460	BDBM110994	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.51	510	O75460	BDBM110995	Serine/threonine-protein kinase/endoribonuclease IRE1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1110735

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2009
Volume: 19
Issue: 17
First Page: 4952
Last Page: 4957
DOI: 10.1016/j.bmcl.2009.07.082

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1110734

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2009
Volume: 19
Issue: 17
First Page: 4952
Last Page: 4957
DOI: 10.1016/j.bmcl.2009.07.082

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: IGROV1_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, IGROV1 is panel number 6, cell number 10. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
0809OS51	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	89.6274	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	94.0185	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	77.1805	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	76.1686	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	82.5618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	88.7561	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	83.5845	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	92.7497	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	70.9555	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	58.7306	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.6041	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	90.3839	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	110.2345	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	97.6538	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	93.7697	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	56.4618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	80.8893	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	79.078	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	-20.3008	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.0949	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_7561_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.034	34	O75460	BDBM110972	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.079	79	O75460	BDBM110973	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.08	80	O75460	BDBM110974	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.1	100	O75460	BDBM110975	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.08	80	O75460	BDBM110975	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.11	110	O75460	BDBM110976	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.17	170	O75460	BDBM110978	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.17	170	O75460	BDBM110979	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.102	102	O75460	BDBM110979	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.24	240	O75460	BDBM110980	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.24	240	O75460	BDBM110981	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.25	250	O75460	BDBM110982	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.27	270	O75460	BDBM110983	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.022	22	O75460	BDBM110983	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.28	280	O75460	BDBM110984	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.3	300	O75460	BDBM110985	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.772	772	O75460	BDBM110985	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.35	350	O75460	BDBM110986	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.38	380	O75460	BDBM110987	Serine/threonine-protein kinase/endoribonuclease IRE1
IC50	0.38	380	O75460	BDBM110988	Serine/threonine-protein kinase/endoribonuclease IRE1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4053389

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2017
Volume: 80
Issue: 2
First Page: 278
Last Page: 289
DOI: 10.1021/acs.jnatprod.6b00643

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	77.3	%
Inhibition	=	7.5	%
Inhibition	=	81.3	%
Inhibition	=	18.5	%
Inhibition	=	5.5	%
Inhibition	=	37.8	%

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

148-53-8 靶点实验数据

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2