HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5141201

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 14.0
First Page: 9564
Last Page: 9579
DOI: 10.1021/acs.jmedchem.2c00680

Standard Type	Standard Relation	Standard Value
LogD	=	1.8
LogD	=	0.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lysine-specific demethylase 4C

External ID: CHEMBL3778164

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 4
First Page: 1357
Last Page: 1369
DOI: 10.1021/acs.jmedchem.5b01537

Target ChEMBL ID: CHEMBL6175
ChEMBL Target Name: Lysine-specific demethylase 4C
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.12589	IC50	=	125.89	nM
0.0631	IC50	=	63.1	nM
0.1	IC50	=	100	nM
0.07943	IC50	=	79.43	nM
0.1	IC50	<=	100	nM
1.58489	IC50	=	1584.89	nM
0.12589	IC50	=	125.89	nM
0.31623	IC50	=	316.23	nM
0.50119	IC50	=	501.19	nM
0.63096	IC50	=	630.96	nM
0.12589	IC50	=	125.89	nM
0.12589	IC50	=	125.89	nM
0.19953	IC50	=	199.53	nM
0.15849	IC50	=	158.49	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lysine-specific demethylase 6B

External ID: CHEMBL3778163

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 4
First Page: 1357
Last Page: 1369
DOI: 10.1021/acs.jmedchem.5b01537

Target ChEMBL ID: CHEMBL1938211
ChEMBL Target Name: Lysine-specific demethylase 6B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
12.5892	IC50	=	12589.25	nM
100	IC50	>	100000	nM
1.25893	IC50	=	1258.93	nM
39.8107	IC50	=	39810.72	nM
6.30957	IC50	=	6309.57	nM
0.79433	IC50	=	794.33	nM
1.99526	IC50	=	1995.26	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prolyl hydroxylase EGLN3

External ID: CHEMBL3778166

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 4
First Page: 1357
Last Page: 1369
DOI: 10.1021/acs.jmedchem.5b01537

Target ChEMBL ID: CHEMBL5705
ChEMBL Target Name: Egl nine homolog 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50.1187	IC50	>	50118.72	nM
50.1187	IC50	>	50118.72	nM
50.1187	IC50	>	50118.72	nM
31.6228	IC50	=	31622.78	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lysine-specific demethylase 4D

External ID: CHEMBL3778165

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 4
First Page: 1357
Last Page: 1369
DOI: 10.1021/acs.jmedchem.5b01537

Target ChEMBL ID: CHEMBL6138
ChEMBL Target Name: Lysine-specific demethylase 4D
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	IC50	=	100	nM
0.25119	IC50	=	251.19	nM
0.39811	IC50	=	398.11	nM
0.0631	IC50	=	63.1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lysine-specific demethylase 4C

External ID: CHEMBL3779254

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 4
First Page: 1357
Last Page: 1369
DOI: 10.1021/acs.jmedchem.5b01537

Target ChEMBL ID: CHEMBL6175
ChEMBL Target Name: Lysine-specific demethylase 4C
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.30957	IC50	=	6309.57	nM
39.8107	IC50	=	39810.72	nM
7.94328	IC50	=	7943.28	nM
100	IC50	>	100000	nM
39.8107	IC50	=	39810.72	nM

1461602-86-7 靶点实验数据