HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 8

External ID: CHEMBL4266931

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 19
First Page: 3216
Last Page: 3221
DOI: 10.1016/j.bmcl.2018.08.015

Target ChEMBL ID: CHEMBL5805
ChEMBL Target Name: Toll-like receptor 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.14	MEC	=	0.14	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL4266930

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 19
First Page: 3216
Last Page: 3221
DOI: 10.1016/j.bmcl.2018.08.015

Target ChEMBL ID: CHEMBL5936
ChEMBL Target Name: Toll-like receptor 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.4	MEC	=	2.4	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_7979_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	EC50 Qualifier	EC50	Target Accession(s)	Ligand	Target
EC50	>	100	>	100000	Q9NYK1	BDBM60954	Toll-like receptor 7
EC50		0.58		580	Q9NR97	BDBM227459	Toll-like receptor 8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL4296184

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 24.4 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib -0.9 Pct
5	MIC	=	5000	nM	Median N= 2
	Inhibition	=	7.42	%	Average; N=2
0.0781	MIC	<=	78.1	nM	Median N= 2
	Inhibition	=	5.44	%	Average; N=2
	Inhibition	=	-0.36	%	Average; N=2
	Inhibition	=	-1.51	%	Average; N=2
	Inhibition	=	9.71	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 6.2 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 14.7 Pct
	Inhibition	=	13.34	%	Average; N=2
	Inhibition	=	5.78	%	Average; N=2
	Inhibition	=	15.7	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 11.5 Pct
5	MIC	=	5000	nM	Median N= 2
5	MIC	=	5000	nM	Median N= 2
	Inhibition	=	9.69	%	Average; N=2
2.5	MIC	=	2500	nM	Median N= 2; Range 5 - 2.5 Um
	Inhibition	=	12.6	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella pneumoniae

External ID: CHEMBL4296186

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL350
ChEMBL Target Name: Klebsiella pneumoniae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	0.93	%	Average; N=2
Inhibition	=	16.87	%	Average; N=4
Inhibition	=	14.36	%	Average; N=4
Inhibition	=	8.63	%	Average; N=2
Inhibition	=	22.77	%	Average; N=2
MIC	>	32	ug.mL-1	Median N= 2; Maxinhib 12.7 Pct
Inhibition	=	-22.42	%	Average; N=2	Outside typical range
Inhibition	=	0.23	%	Average; N=4
MIC	>	32	ug.mL-1	Median N= 2; Maxinhib 20.1 Pct
Inhibition	=	10.23	%	Average; N=4
Inhibition	=	3.15	%	Average; N=4
Inhibition	=	7.81	%	Average; N=4
Inhibition	=	-10.52	%	Average; N=4	Outside typical range
MIC	>	32	ug.mL-1	Median N= 2; Maxinhib 19.8 Pct
Inhibition	=	7.19	%	Average; N=4
Inhibition	=	6.16	%	Average; N=2
Inhibition	=	11.98	%	Average; N=4
Inhibition	=	3.45	%	Average; N=2
Inhibition	=	3.96	%	Average; N=2
Inhibition	=	4.88	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL4296185

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 62.6 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 7.3 Pct
0.625	MIC	=	625	nM	Median N= 2
	Inhibition	=	3.55	%	Average; N=2
10	MIC	=	10000	nM	Median N= 2
	Inhibition	=	-0.79	%	Average; N=2
	Inhibition	=	-2.76	%	Average; N=2
	Inhibition	=	6.59	%	Average; N=2
	Inhibition	=	3.05	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 8.1 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 17.5 Pct
	Inhibition	=	-6.11	%	Average; N=2
	Inhibition	=	3.59	%	Average; N=2
	Inhibition	=	-1.89	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 7.5 Pct
1.25	MIC	=	1250	nM	Median N= 2; Range 2.5 - 1.25 Um
2.5	MIC	=	2500	nM	Median N= 2
	Inhibition	=	2.4	%	Average; N=2
5	MIC	=	5000	nM	Median N= 2; Range 10 - 5 Um
	Inhibition	=	-4.2	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5241470

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2021
Volume: 218
First Page: 113356
Last Page: 113356
DOI: 10.1016/j.ejmech.2021.113356

Target ChEMBL ID: CHEMBL5936
ChEMBL Target Name: Toll-like receptor 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	EC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：N/A

External ID: OBG420

Protocol: Assay Protocol Summary:

1,000 cells in 4 uL of media were dispensed into white, solid bottom 1536-well plates using a Multidrop Combi (Thermo Scientific). The Assay plates were incubated for 16 hours at 37 C with 5% CO2 in assay plates, followed by the addition of 23 nL of DMSO or drug dissolved in DMSO. Each compound was assayed in five concentrations (0.092, 0.46, 2.3, 11.5, and 57.5 uM), using the automated Wako 1536 Pin Tool workstation and incubated at 37 C with 5% CO2 48 hours. 4 uL of ATPlite, the ATP monitoring reagent, was then added to the each well of the assay plates using the Multidrop Combi reagent dispenser followed by incubation for 15 minutes at room temperature. The resulting luminescence was measured using the ViewLux plate reader.

Comment: Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, cytotoxic compounds are considered active and show up as apparent inhibitors, which are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype	Potency	Efficacy	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.051 uM	Activity at 0.256 uM	Activity at 1.283 uM	Activity at 6.551 uM	Activity at 25.26 uM	Activity at 38.52 uM	Panel ID	Panel Name
Inactive	0.0891	20.4377	-7.05	4.9549	0.5243	16	-4.4377	4	0 0 0 0 0	13.1195	-1.6147	23.0221	4.9232	22.4364		13.1195	3	PA-1
Inactive	0.5012	19.512	-6.3	4.5045	0.9837	2.5	-17.012	4	0 0 0 0 0	4.6148	-17.0933	-15.139	2.0203	0.9631		4.6148	4	SKOV3
Inactive	0.0891	10.1784	-7.05	4.9549	0.4664	-7.6784	2.5	4	0 0 0 0 0	-7.2247	0.9983	-11.3986	-10.48	-0.961		-7.2247	5	C33A
Inactive		0				0	0	4		6.8018	-1.7943	7.9288	7.7169	7.1557		6.8018	6	JEG-3
Inactive	0.631	5.8754	-6.2	4.9549	0.6533	5	-0.8754	4	0 0 0 0 0	4.9978	0.7404	-1.9795	8.0951	2.3607		4.9978	7	Es-2
Inactive		0				0	0	4		-1.5659	2.9339	-4.8958	-4.7951	1.5969		-1.5659	8	Hek293T
Inactive	0.0891	9.995	-7.05	4.9549	0.3786	-7.495	2.5	4	0 0 0 0 0	-5.4128	1.1477	-11.5205	-0.3743	-12.9125		-5.4128	9	Tov112D
Inactive		0				0	0	4		-3.2957	3.8308	1.4062	-4.436	-2.7163		-3.2957	10	Tov-21-G
Inactive	0.7079	14.6604	-6.15	4.9549	0.9994	11.5	-3.1604	4	0 0 0 0 1	1.8313	-3.0503	-3.0355	11.1111	11.2024		1.8313	11	OV90
Inactive	2.5119	11.0392	-5.6	1.6259	0.9918	4.5	-6.5392	4	0 0 0 0 0	4.3244	-5.7563	-6.6993	-3.0441	3.0217		4.3244	12	CASKI
Inactive		0				0	0	4		4.0002	9.2609	1.7307	16.1689	8.2706	4.0002		1	CAOV3
Inactive	0.1	12.4224	-7	1.6436	0.8881	-1.9224	10.5	4	0 0 0 0 0	-4.5186	7.7607	0.4819	-0.6217	-0.7957	-4.5186		2	HeLa
Inactive		0				0	0	4		9.027	13.2513	1.7412	13.5275	17.6857	9.027		3	PA-1
Inactive	0.3162	18	-6.5	4.4495	0.9637	7	25	4	0 0 0 0 1	19.6871	25.2034	21.5131	5.0173	9.4271	19.6871		4	SKOV3
Inactive		0				0	0	4		0.3369	0.4452	-0.9125	5.7292	4.44	0.3369		5	C33A
Inactive	0.0631	10.5	-7.2	4.9549	0.8451	2	12.5	4	0 0 0 0 0	1.0879	10.8386	0.1902	2.4619	4.6395	1.0879		6	JEG-3
Inactive	0.5012	9.5598	-6.3	4.9549	0.9517	0	-9.5598	4	0 0 0 0 0	-0.0179	-8.4158	-10.4665	0.9667	-1.2439	-0.0179		7	Es-2
Inactive	0.0631	14.8119	-7.2	4.9549	0.534	-5.8119	9	4	0 0 0 0 1	0.2814	6.5861	-12.7599	1.4268	-6.0897	0.2814		8	Hek293T
Inactive	8.9125	8.541	-5.05	4.045	0.614	8	-0.541	4	0 0 0 0 0	7.7519	3.7595	-4.2009	-0.5734	0.6635	7.7519		9	Tov112D
Inactive		0				0	0	4		1.0625	-0.4666	0.2533	-1.2691	-7.1333	1.0625		10	Tov-21-G

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4303805

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	-11.52	%	Outside typical range
Inhibition	=	5.09	%
Inhibition	=	-1.71	%
Inhibition	=	3.69	%
Inhibition	=	22.47	%
Inhibition	=	8.51	%
Inhibition	=	-6.86	%
Inhibition	=	-6.18	%
Inhibition	=	-2.07	%
Inhibition	=	3.91	%
Inhibition	=	-5.9	%
Inhibition	=	-2.45	%
Inhibition	=	-5.55	%
Inhibition	=	6.31	%
Inhibition	=	-1.08	%
Inhibition	=	12.7	%
Inhibition	=	0.37	%
Inhibition	=	8.88	%
Inhibition	=	11.63	%
Inhibition	=	-1.96	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5511268

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5511267

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5511266

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL4296191

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	CC50	>	10000	nM	Median N= 2; Maxinhib 33.3 Pct
2.37	CC50	=	2370	nM	Median N= 2; Range 3.25 - 2.37 Um
20	CC50	>	20000	nM	Median N= 2; Maxinhib 28.6 Pct
10	CC50	>	10000	nM	Median N= 2; Maxinhib 38.8 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 25.1 Pct
10	CC50	>	10000	nM	Median N= 2; Maxinhib 14.6 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 9.0 Pct
1.13	CC50	=	1130	nM	Median N= 2; Range 1.16 - 1.13 Um
10	CC50	>	10000	nM	Median N= 2; Maxinhib 21.9 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 27.6 Pct
10	CC50	>	10000	nM	Median N= 2; Maxinhib 12.3 Pct
10	CC50	>	10000	nM	Median N= 2; Maxinhib 39.0 Pct
10	CC50	>	10000	nM	Median N= 2; Maxinhib 44.0 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 19.6 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 26.9 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 32.2 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 16.0 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 33.3 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 40.6 Pct
20	CC50	>	20000	nM	Median N= 2; Maxinhib 27.8 Pct

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5511265

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5511264

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL5511263

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acinetobacter baumannii

External ID: CHEMBL4296188

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL614425
ChEMBL Target Name: Acinetobacter baumannii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 10.4 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 10.3 Pct
5	MIC	=	5000	nM	Median N= 2
	Inhibition	=	22.02	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 7.2 Pct
	Inhibition	=	0.29	%	Average; N=2
	Inhibition	=	13.44	%	Average; N=2
	Inhibition	=	15.75	%	Average; N=2
	Inhibition	=	30.31	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 19.9 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 13.5 Pct
	Inhibition	=	12.68	%	Average; N=2
	Inhibition	=	8.04	%	Average; N=2
	Inhibition	=	21.28	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 17.6 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 10.9 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 24.8 Pct
	Inhibition	=	19.94	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 15.2 Pct
	Inhibition	=	19.7	%	Average; N=2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL4296187

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	10.84	%	Average; N=1
Inhibition	=	14.55	%	Average; N=1
Inhibition	=	-13.46	%	Average; N=1	Outside typical range
Inhibition	=	21.47	%	Average; N=2
Inhibition	=	32.07	%	Average; N=1
Inhibition	=	2.27	%	Average; N=1
Inhibition	=	-21.74	%	Average; N=1	Outside typical range
Inhibition	=	9.41	%	Average; N=1
Inhibition	=	19.34	%	Average; N=1
Inhibition	=	-25.08	%	Average; N=1	Outside typical range
Inhibition	=	9.21	%	Average; N=4
Inhibition	=	15.98	%	Average; N=4
Inhibition	=	8.03	%	Average; N=1
Inhibition	=	-1.26	%	Average; N=1
Inhibition	=	6.81	%	Average; N=1
Inhibition	=	-8.48	%	Average; N=1
Inhibition	=	25.25	%	Average; N=1
Inhibition	=	44.67	%	Average; N=1
Inhibition	=	1.69	%	Average; N=1
Inhibition	=	2.93	%	Average; N=1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 8

External ID: CHEMBL5511261

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL5805
ChEMBL Target Name: Toll-like receptor 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	Activity				Not Active
125.21	EC50	=	125210	nM		Outside typical range
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cryptococcus neoformans

External ID: CHEMBL4296190

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL365
ChEMBL Target Name: Cryptococcus neoformans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 9.6 Pct
	Inhibition	=	-7.36	%	Average; N=2; Conc=25 Um ;
20	MIC	>	20000	nM	Median N= 2; Maxinhib 17.1 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 6.5 Pct
	Inhibition	=	-5.61	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 7.2 Pct
	Inhibition	=	-0.18	%	Average; N=2
	Inhibition	=	-8.54	%	Average; N=2
	Inhibition	=	-5.03	%	Average; N=2
	Inhibition	=	-1.5	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 8.8 Pct
0.1563	MIC	=	156.3	nM	Median N= 2
	Inhibition	=	-9.6	%	Average; N=2; Conc=25 Um ;
	Inhibition	=	-0.09	%	Average; N=2
	Inhibition	=	-3.07	%	Average; N=2
	Inhibition	=	-2.97	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 9.3 Pct
	Inhibition	=	-12.66	%	Average; N=2; Conc=25 Um ;	Outside typical range
10	MIC	>	10000	nM	Median N= 2; Maxinhib 4.5 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 9.3 Pct

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5511260

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 10
First Page: 8346
Last Page: 8360
DOI: 10.1021/acs.jmedchem.4c00464

Target ChEMBL ID: CHEMBL5936
ChEMBL Target Name: Toll-like receptor 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.83	EC50	=	1830	nM
0.23	EC50	=	230	nM
0.22	EC50	=	220	nM
0.35	EC50	=	350	nM
2.92	EC50	=	2920	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL4296189

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	MIC	>	10000	nM	Median N= 2; Maxinhib 3.0 Pct
	Inhibition	=	8.04	%	Average; N=2; Conc=25 Um ;
20	MIC	>	20000	nM	Median N= 2; Maxinhib 7.4 Pct
10	MIC	>	10000	nM	Median N= 2; Maxinhib 4.8 Pct
	Inhibition	=	3.92	%	Average; N=2
10	MIC	>	10000	nM	Median N= 2; Maxinhib 10.4 Pct
	Inhibition	=	-0.23	%	Average; N=2
	Inhibition	=	0.3	%	Average; N=2
	Inhibition	=	-0.48	%	Average; N=2
	Inhibition	=	2.62	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 8.0 Pct
0.0781	MIC	<=	78.1	nM	Median N= 2
	Inhibition	=	-3.39	%	Average; N=2; Conc=25 Um ;
	Inhibition	=	5.22	%	Average; N=2
	Inhibition	=	3.37	%	Average; N=2
	Inhibition	=	4.56	%	Average; N=2
20	MIC	>	20000	nM	Median N= 2; Maxinhib 3.4 Pct
	Inhibition	=	-0.73	%	Average; N=2; Conc=25 Um ;
10	MIC	>	10000	nM	Median N= 2; Maxinhib 7.9 Pct
20	MIC	>	20000	nM	Median N= 2; Maxinhib 1.4 Pct

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL4296802

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	-33.42	%	Average; N=1	Outside typical range
Inhibition	=	1.44	%	Average; N=1
Inhibition	=	-11.05	%	Average; N=1	Outside typical range
Inhibition	=	19.22	%	Average; N=1
Inhibition	=	-31.54	%	Average; N=1	Outside typical range
Inhibition	=	-12.91	%	Average; N=1	Outside typical range
Inhibition	=	12.18	%	Average; N=1
Inhibition	=	-14.83	%	Average; N=1	Outside typical range
Inhibition	=	17.54	%	Average; N=1
Inhibition	=	-38.58	%	Average; N=1	Outside typical range
Inhibition	=	-10.22	%	Average; N=1	Outside typical range
Inhibition	=	14	%	Average; N=1
Inhibition	=	1.67	%	Average; N=1
Inhibition	=	14.76	%	Average; N=1
Inhibition	=	-28.2	%	Average; N=1	Outside typical range
Inhibition	=	13.08	%	Average; N=1
Inhibition	=	3.75	%	Average; N=1
Inhibition	=	10.88	%	Average; N=1
Inhibition	=	-0.78	%	Average; N=1
Inhibition	=	-7.12	%	Average; N=1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Erythrocyte

External ID: CHEMBL4296784

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4296518
ChEMBL Target Name: Erythrocyte
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: CO-ADD Antimicrobial Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
20	HC10	>	20	uM	Median N= 2; Maxinhib 9.1 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 1.0 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 7.0 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 5.3 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 2.5 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 3.3 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 3.5 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 3.4 Pct
10	HC10	>	10	uM	Median N= 2; Maxinhib 1.6 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 6.2 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 20.2 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 1.8 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 5.9 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 3.4 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 8.2 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 3.2 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 9.3 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 7.8 Pct
20	HC10	>	20	uM	Median N= 2; Maxinhib 1.6 Pct
10	HC10	>	10	uM	Median N= 2; Maxinhib 10.1 Pct

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 8

External ID: CHEMBL5037111

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL5805
ChEMBL Target Name: Toll-like receptor 8
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.059	EC50	=	59	nM
0.62	EC50	=	620	nM
1.4	EC50	=	1400	nM
0.095	EC50	=	95	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037110

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL5936
ChEMBL Target Name: Toll-like receptor 7
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.07	EC50	=	70	nM
0.89	EC50	=	890	nM
1.65	EC50	=	1650	nM
0.156	EC50	=	156	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Replicase polyprotein 1ab

External ID: CHEMBL4495582

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13.77	%
Inhibition	=	2.35	%
Inhibition	=	21.17	%
Inhibition	=	18.36	%
Inhibition	=	5.381	%
Inhibition	=	18.17	%
Inhibition	=	10.15	%
Inhibition	=	29.56	%
Inhibition	=	18.27	%
Inhibition	=	11.42	%
Inhibition	=	15.4	%
Inhibition	=	7.437	%
Inhibition	=	-3.216	%
Inhibition	=	18	%
Inhibition	=	1.021	%
Inhibition	=	16.4	%
Inhibition	=	2.544	%
Inhibition	=	19.11	%
Inhibition	=	26.15	%
Inhibition	=	5.133	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: CYP3A7681

Protocol: Assay Protocol Summary:

Two ul of enzyme-substrate mix was dispensed into medium binding white/solid 1536-well plates (Greiner Bio-One North America Inc., Monroe, NC) using a Flying Reagent Dispenser (FRD, Aurora Discovery, San Diego, CA). Compounds dissolved in DMSO, and positive control (ketoconazole) were transferred to the assay plates at 23 nl using a Pintool station (Wako, San Diego, CA). The assay plates were incubated at room temperature for 10 min. Then 2 ul of NADPH regeneration solution was added to each well of the assay plates using an FRD and incubated at room temperature for 1 h. The reaction was stopped by adding 4 ul of detection reagent using an FRD and after 20 min incubation at room temperature the luminescence signal was measured using a ViewLux plate reader (Perkin Elmer, Shelton, CT). Data were expressed as relative luminescence units.

Comment: Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype	Potency	Efficacy	Activity_Score	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.0003678000 uM	Activity at 0.0007363003 uM	Activity at 0.00153 uM	Activity at 0.00368 uM	Activity at 0.00914 uM	Activity at 0.018 uM	Activity at 0.039 uM	Activity at 0.092 uM	Activity at 0.191 uM	Activity at 0.460 uM	Activity at 1.182 uM	Activity at 2.302 uM	Activity at 4.834 uM	Activity at 11.49 uM	Activity at 23.94 uM	Activity at 57.45 uM	Compound QC
Inhibitor	1.0964	121.5245	87	Complete curve; high efficacy	-5.96	0.6	0.996	-99.001	22.5235	-1.1	0 0 0 0 0 0 0 0	-91.4164		21.201		18.0897		11.5563		3.2362		-23.6097		-54.3722		-70.1237		-91.4164	QC'd by GVK
Inactive			0					0	0	4		1.3029		6.409		5.7452		-8.1274		11.4345		12.799		5.9113		7.1389		1.3029	QC'd by Vitas
Inhibitor	0.055	96.7494	90	Complete curve; high efficacy	-7.26	0.6	0.9836	-74.1574	22.592	-1.1	0 0 0 0 0 0 0 0	-78.8495		12.3459		12.9899		-11.4013		-37.5586		-53.042		-61.5426		-65.313		-78.8495	QC'd by Bosche
Inactive			0					0	0	4		-9.339		-4.094		-2.8674		4.5071		-4.4459		-5.3433		-2.4671		3.5091		-9.339	QC'd by BIOMOL
Inactive			0		-6.61	4.9549	0.7785	2.5	-6.0941	4	0 0 0 0 0 0 0 1	-8.7946		-5.07		-2.6335		-5.97		-10.4951		3.4911		2.0588		1.9174		-8.7946	QC'd by SIGMA
Inhibitor	34.6713	39.827	10	Single point of activity	-4.46	2.3031	0.825	-41.327	-1.5	-3	0 0 0 0 0 0 0 0	-31.9392		3.6009		-5.2617		2.2295		4.1407		-8.6455		-6.9529		-4.2362		-31.9392	QC'd by Microsource
Inactive			0							4	0 0 0 0 0 0 0 0	-13.8986		20.6492		16.422		11.6893		9.5011		16.6467		-2.6177		-2.1673		-13.8986	QC'd by Vitas
Inhibitor	15.4871	78.5667	41	Partial curve; partial efficacy	-4.81	0.8	0.995	-76.672	1.8947	-2.2	0 0 0 0 0 0 0 0	-58.0849		2.7342		0.6745		4.0214		-0.609		-3.975		-12.9528		-31.6593		-58.0849	QC'd by Sequoia
Inactive			0					0	0	4		26.6445	12.4429		-0.6442		19.3784		7.3352		0.3513		4.2285		7.4344		26.6445		QC'd by Microsource
Inactive			0		-5.9213	4.9549	0.7942	3.5	-5.6452	4	0 0 0 0 0 0 1	-9.4213				-2.1113		-8.4544		-4.6822		-8.2265		4.1606		2.7472		-9.4213	QC'd by Tocris
Inactive			0					0	0	4		-2.8012		-11.1342		-2.192		0		-10.8176		-0.6934		-3.3166		-1.4979		-2.8012	QC'd by SIGMA
Inactive			0		-5.76	4.9549	0.5104	28.8996	-2.448	4	0 1 0 0 0 0 0 1	-2.305		23.7377		-36.8683		-4.4543		-19.5675		-9.3801		22.2432		29.0984		-2.305	QC'd by Vitas
Inhibitor	12.3018	87.4011	42	Partial curve; high efficacy	-4.91	0.6	0.9549	-73.5501	13.8509	-2.1	0 0 0 0 0 0 0 0	-54.8735		22.1453		8.3684		12.1328		9.0141		-1.3852		-8.6537		-22.9862		-54.8735	QC'd by Microsource
Inhibitor	27.5404	50.2393	10	Single point of activity	-4.56	1.7529	0.9401	-50.1648	0.0744	-3	0 0 0 0 0 0 0 0	-39.14		2.8036		-3.0335		1.3596		-6.0162		5.1159		-1.7887		-9.2175		-39.14	QC'd by Microsource
Inactive			0		-5.31	0.6	0.8041	-16.0136	17	4	0 0 0 0 0 0 0 0	-11.678		17.6825		13.4358		21.7597		6.5197		17.4375		-0.6278		-0.9036		-11.678	QC'd by Enzo
Inhibitor	15.4871	77.5471	10	Partial curve; partial efficacy; poor fit	-4.81	1.111	0.829	-67.106	10.4411	-2.4	0 0 0 0 0 0 0 0	-53.0541		0.7435		24.1655		2.7053		1.7382		25.7669		-4.8999		-19.2859		-53.0541	QC'd by Bosche
Inactive			0		-6.36	1.4641	0.8922	-22.4758	4.5	4	0 0 0 0 0 0 0 0	-25.4997		2.5425		6.3039		7.767		-1.9911		-6.3102		-26.2299		-15.2464		-25.4997	QC'd by Microsource
Inactive			0		-4.51	1.9673	0.499	14	26.5	4	0 0 0 0 0 0 0 0	16.8462		25.5317		32.6702		20.2852		28.5693		25.6359		26.9817		25.0297		16.8462	QC'd by GVK
Inhibitor	0.8709	47.2788	24	Complete curve; partial efficacy	-6.06	4.9549	0.9676	-45.6766	1.6021	-1.2	0 0 0 0 0 0 0 1	-20.5127		8.2743		0.9756		-1.5573		-1.3097		0.8922		-49.683		-41.1152		-20.5127	QC'd by Enzo
Inactive			0		-6.06	4.9549	0.439	9	-0.6762	4	0 0 0 0 0 0 0 1	-0.013		1.9538		1.5464		-4.3135		0.312		-2.7682		16.9354		0.8252		-0.013	QC'd by Sequoia

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: APP-Toga-CHIKV-nsp2-p

Protocol: PROTOCOL TABLE (as described by Inglese J, Shamu CE and Guy RK. 2007)
SEQUENCE No. (e.g., 1, 2, 3, etc.); PARAMETER (e.g., Cells, Incubation, Reagent, etc.); VALUE; DESCRIPTION.
1; Control / Compound; 20 nL; Echo 655 acoustic dispenser, Greiner 1536-well solid bottom black plate.
2; Enzyme; 4 uL; BioRAPTR FRD liquid dispenser (Beckman Coulter).
3; Incubation; 15 min; room temperature.
4; Reagent; 4 uL; 2.5 uM Peptide 2 substrate.
5; Incubation; 1 hr; room temperature.
6; Detection; Fluorescence; WiewLux microplate reader (PerkinElmer), 525 nm excitation, 598/25 nm emission.

NOTES (numbers refer to sequence numbers above).
1. Briefly, 20 nL DMSO, positive control ZnAc (20nM final concentration), and test compounds were transferred into a 1,536-well solid bottom black plate (789176-F, Greiner One) via Echo 655 acoustic dispenser (Beckman Coulter). For primary screens, compounds were tested at 7 concentrations, 1:3 dilution points ranging from 25 uM to 34 nM. Follow-up confirmatory screens were carried out at 11 concentrations, 1:3 dilution points from 25 uM to 0.42 nM.
2. Four uL nsP2pro enzyme mix (150 nM final concentration) in 10 mM Tris-HCl pH 8.0 with 0.01% Tween 20 assay buffer was dispensed into the plate using a BioRAPTR FRD liquid dispenser (Beckman Coulter).
3. The plate was incubated at room temperature (protected from light) for 15 min
4. Four microliter of peptide 2 substrate (2.5 uM final concentration) in assay buffer was added to the plate.
5. After 1 hour, plates were immediately read on a ViewLux high-throughput CCD imager (Exposure = 10 sec, Gain = High, Speed = Slow, Binning = 2X). The above assay was also incorporated in the NCATS HTS facility41, which allowed for robotic liquid and compound dispensing, microplate handling, and fluorescence reading..

REFERENCE:
Inglese J, Shamu CE and Guy RK, Reporting data from high throughput screening of small molecule libraries, Nature Chemical Biology, 2007, 3(8): 438-441. doi.org/10.1038/nchembio0807-438.

Comment: Disclaimer:
Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods [1].

Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, with a ratio activity curve class of 4, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. For a ratio activity curve class = -1.1, score = 80+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 && abs(ratio.max_response) > 6*10, score = 60+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -2.1 || ( ratio.curve_class==-2.2 && abs(ratio.max_response) > 6*10), score = 40+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 || ratio.curve_class == -2.2, score = 20+abs((log_ac50+4.5)*inf_activity/20). Inconclusive compounds, with a donor curve class other than 4, have PUBCHEM_ACTIVITY_SCORE of 10. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39.

Reference:
1. Inglese J, Auld DS, Jadhav A, et al. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A. 2006;103(31):11473-11478.

Phenotype	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.0001439601 uM	Activity at 0.0003895389 uM	Activity at 0.00154 uM	Activity at 0.00290 uM	Activity at 0.00833 uM	Activity at 0.041 uM	Activity at 0.095 uM	Activity at 0.199 uM	Activity at 0.321 uM	Activity at 0.689 uM	Activity at 1.028 uM	Activity at 2.684 uM	Activity at 5.101 uM	Activity at 10.05 uM	Activity at 24.85 uM	Compound QC
Inactive				0	0	4		58.4116	43.5916	25.8843	33.4207	9.1109	21.6395	45.6886	10.8911		28.3955	31.3127		38.9914		41.6558	58.4116	QC'd by Sytravon
Inactive				0	0	4		-12.6805						-10.7548		-9.5107			-10.6418		-15.9997		-12.6805	QC'd by Sytravon
Inactive				0	0	4		-7.1462						-9.2235		-11.8601			-6.118		-12.2196		-7.1462	QC'd by Sytravon
Inactive	-4.75	4.9549	0.6661	-22.0013	-2	4	0 0 0 0 0	-18.751						-10.987		-0.9935			2.356		1.2583		-18.751	QC'd by Sytravon
Inactive				0	0	4		-11.1249						-10.2692		-11.5229			-11.032		-13.325		-11.1249	QC'd by Sytravon
Inactive	-4.8	1.8851	0.5555	-23.9168	-5.4088	4	0 0 0 0 0	-18.264						-13.0121		-2.8407			-6.6548		-7.1687		-18.264	QC'd by Sytravon
Inactive	-6.35	4.9549	0.9083	-3.1815	-14.9283	4	0 0 0 0 1	-10.2909						-13.1276		-17.0236			-1.4012		-4.6174		-10.2909	QC'd by Sytravon
Inactive	-5.95	0.4	0.9812	-20.7272	-0.9942	4	0 0 0 0 0	-16.0227						-4.9952		-8.1266			-9.7286		-14.3153		-16.0227	QC'd by Sytravon
Inactive	-6.5	4.9549	0.6409	-9.2158	-16.6011	4	0 0 0 0 1	-12.7654						-16.3342		-16.1896			-6.0131		-13.084		-12.7654	QC'd by Sytravon
Inactive				0	0	4		1.975						2.6103		3.4198			-3.4748		1.7624		1.975	QC'd by Sytravon
Inactive				0	0	4		-8.2223						-0.1456		-4.3339			-1.582		-3.6253		-8.2223	QC'd by Sytravon
Inactive	-7.25	4.9549	0.602	-10.0715	2	4	0 0 0 0 0	-12.6011						0.2325		-14.2262			-4.5441		-8.7364		-12.6011	QC'd by Sytravon
Inactive	-4.75	4.5045	0.9809	-24.6554	-10.8442	4	0 0 0 0 0	-22.2129						-9.8702		-10.3098			-11.7375		-10.6121		-22.2129	QC'd by Sytravon
Inactive	-4.75	4.9549	0.8409	-13.5514	2	4	0 0 0 0 0	-11.2928						-1.9276		4.6106			1.3336		4.0275		-11.2928	QC'd by Sytravon
Inactive	-5.2	0.5	0.9077	-28.8252	-9.4452	4	0 0 0 0 0	-23.1876						-10.7877		-12.0613			-16.7104		-16.3414		-23.1876	QC'd by Sytravon
Inactive				0	0	4		-18.3436						-16.2788		-21.7212			-19.8613		-16.6894		-18.3436	QC'd by Sytravon
Inactive				0	0	4		-5.4025						-9.518		-0.1694			0.2848		-4.8162		-5.4025	QC'd by Sytravon
Inactive				0	0	4		-23.1229						-14.0834		-13.5556			-16.7644		-18.8145		-23.1229	QC'd by Sytravon
Inactive	-4.95	3.2975	0.9426	-35.5663	-15.2262	4	0 0 0 0 0	-34.2687						-12.6885		-18.3414			-14.0693		-16.4909		-34.2687	QC'd by Sytravon
Inactive	-4.75	4.9549	0.7952	-15.6253	-4.8932	4	0 0 0 0 0	-13.8544						-4.3645		-8.5252			-3.661		-3.9903		-13.8544	QC'd by Sytravon

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5037149

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peritoneal macrophage

External ID: CHEMBL5520421

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 5
First Page: 3321
Last Page: 3338
DOI: 10.1021/acs.jmedchem.3c01504

Target ChEMBL ID: CHEMBL5314330
ChEMBL Target Name: Peritoneal macrophage
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	29.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5037148

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peritoneal macrophage

External ID: CHEMBL5520416

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 5
First Page: 3321
Last Page: 3338
DOI: 10.1021/acs.jmedchem.3c01504

Target ChEMBL ID: CHEMBL5314330
ChEMBL Target Name: Peritoneal macrophage
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	65.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CT26

External ID: CHEMBL5037142

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL613866
ChEMBL Target Name: CT26
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CT26

External ID: CHEMBL5037140

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL613866
ChEMBL Target Name: CT26
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037135

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037134

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037133

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037132

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037137

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037127

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037131

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037130

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037129

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Toll-like receptor 7

External ID: CHEMBL5037128

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL3137288
ChEMBL Target Name: TLR7 and TLR8
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
ECmax	=	2	ug ml-1
ECmax	=	0.1	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5037183

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CT26

External ID: CHEMBL5037181

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL613866
ChEMBL Target Name: CT26
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CT26

External ID: CHEMBL5037180

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Target ChEMBL ID: CHEMBL613866
ChEMBL Target Name: CT26
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5037186

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5037185

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 11.0
First Page: 7507
Last Page: 7532
DOI: 10.1021/acs.jmedchem.1c00179

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

144875-48-9 靶点实验数据