HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-secretase 1

External ID: CHEMBL1936881

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2012
Volume: 20
Issue: 2
First Page: 784
Last Page: 788
DOI: 10.1016/j.bmc.2011.12.002

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
0.2	IC50	=	200	nM
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
1432	IC50	=	1432000	nM	Outside typical range
91.8	IC50	=	91800	nM
359.2	IC50	=	359200	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4415296

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 9
First Page: 2601
Last Page: 2607
DOI: 10.1021/acs.jnatprod.9b00547

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4415297

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 9
First Page: 2601
Last Page: 2607
DOI: 10.1021/acs.jnatprod.9b00547

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	56.5	%
Activity	=	60.3	%
Activity	=	62.2	%
Activity	=	55.5	%
Activity	=	57.6	%
Activity	=	71.5	%
Activity	=	47.5	%
Activity	=	46.5	%
Activity	=	67	%
Activity	=	34.6	%
Activity	=	60.5	%
Activity	=	40.4	%
Activity	=	59.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4415298

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2019
Volume: 82
Issue: 9
First Page: 2601
Last Page: 2607
DOI: 10.1021/acs.jnatprod.9b00547

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	77	%
Activity	=	92.7	%
Activity	=	75.8	%
Activity	=	101.4	%
Activity	=	58.3	%
Activity	=	77.1	%
Activity	=	92.8	%
Activity	=	57.9	%
Activity	=	71.1	%
Activity	=	38.1	%
Activity	=	51.3	%
Activity	=	52	%
Activity	=	103.9	%

14348-22-2 靶点实验数据