HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906449

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Determined
Activity	Not Determined
Activity	Active
Activity	Not Active
Activity	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1109256

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 23
First Page: 7528
Last Page: 7536
DOI: 10.1021/jm801432r

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906452

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2339342

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1410
Last Page: 1418
DOI: 10.1016/j.bmc.2012.10.048

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
9.35	Ki	=	9350	nM
200	Ki	>	200000	nM	Outside typical range
4.69	Ki	=	4690	nM
88.7	Ki	=	88700	nM
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1641185

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5767
Last Page: 5772
DOI: 10.1016/j.ejmech.2010.09.034

Standard Type	Standard Relation	Standard Value
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4
Ratio	>	4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1109254

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 23
First Page: 7528
Last Page: 7536
DOI: 10.1021/jm801432r

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma cruzi

External ID: CHEMBL1641187

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5767
Last Page: 5772
DOI: 10.1016/j.ejmech.2010.09.034

Target ChEMBL ID: CHEMBL368
ChEMBL Target Name: Trypanosoma cruzi
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Active
Activity				Active
Activity				Active
GI	=	19.1	%
Activity				Active
Activity				Active
Activity				Active
Activity				Active
Activity				Active
Activity				Active
Activity				Active
Activity				Active
GI	=	25	%
GI	=	50	%
GI	=	0	%
Activity				Active
Activity				Active
Activity				Active
Activity				Active
Activity				Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906448

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Not Active
Activity	Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906457

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906458

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Not Determined
Activity	Not Determined
Activity	Non-toxic
Activity	Not Determined
Activity	Not Determined
Activity	Non-toxic
Activity	Non-toxic
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906459

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906460

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906453

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2339341

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1410
Last Page: 1418
DOI: 10.1016/j.bmc.2012.10.048

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	Ki	>	200000	nM	Outside typical range
0.65	Ki	=	650	nM
135	Ki	=	135000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
124	Ki	=	124000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1109262

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 23
First Page: 7528
Last Page: 7536
DOI: 10.1021/jm801432r

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	440	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906454

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL2339340

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1410
Last Page: 1418
DOI: 10.1016/j.bmc.2012.10.048

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.16	Ki	=	160	nM
0.38	Ki	=	380	nM
0.47	Ki	=	470	nM
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
68.7	Ki	=	68700	nM
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906455

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Toxic
Activity	Not Determined
Activity	Not Determined
Activity	Non-toxic
Activity	Not Determined
Activity	Not Determined
Activity	Non-toxic
Activity	Non-toxic
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL2339339

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1410
Last Page: 1418
DOI: 10.1016/j.bmc.2012.10.048

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.77	Ki	=	770	nM
81.5	Ki	=	81500	nM
9.1	Ki	=	9100	nM
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
65	Ki	=	65000	nM
73	Ki	=	73000	nM
54.5	Ki	=	54500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906456

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 14

External ID: CHEMBL2339338

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1410
Last Page: 1418
DOI: 10.1016/j.bmc.2012.10.048

Target ChEMBL ID: CHEMBL3510
ChEMBL Target Name: Carbonic anhydrase XIV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8.79	Ki	=	8790	nM
35.5	Ki	=	35500	nM
48.8	Ki	=	48800	nM
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
200	Ki	>	200000	nM	Outside typical range
8.53	Ki	=	8530	nM
7.97	Ki	=	7970	nM
5.38	Ki	=	5380	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1109259

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 23
First Page: 7528
Last Page: 7536
DOI: 10.1021/jm801432r

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906465

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.5	hr
Activity	=	2	hr
Activity	=	0.5	hr
Activity	=	2	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906466

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	239	umol.kg-1
ED50	=	295	umol.kg-1
ED50	=	151	umol.kg-1
ED50	=	238	umol.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906467

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
TD50	=	1422	umol/Kg
Activity	=	0	%
TD50	=	481	umol/Kg
Activity	=	0	%
TD50	=	385	umol/Kg
Activity	=	0	%
TD50	=	362	umol/Kg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906468

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.5	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906461

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Active
Activity	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906462

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906463

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906464

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Determined
Activity	Not Determined
Activity	Not Active
Activity	Not Active
Activity	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Triosephosphate isomerase, glycosomal

External ID: CHEMBL1641189

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5767
Last Page: 5772
DOI: 10.1016/j.ejmech.2010.09.034

Target ChEMBL ID: CHEMBL5834
ChEMBL Target Name: Triosephosphate isomerase, glycosomal
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition	=	52	%
Inhibition	=	35	%
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition	=	69	%
Inhibition	=	45	%
Inhibition	=	98	%
Inhibition	=	17	%
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Triosephosphate isomerase, glycosomal

External ID: CHEMBL1641190

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2010
Volume: 45
Issue: 12
First Page: 5767
Last Page: 5772
DOI: 10.1016/j.ejmech.2010.09.034

Target ChEMBL ID: CHEMBL5834
ChEMBL Target Name: Triosephosphate isomerase, glycosomal
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	33	%
Inhibition	=	24	%
Inhibition	=	18	%
Inhibition	=	83	%
Inhibition	=	93	%
Inhibition	=	30	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	76	%
Inhibition	=	14	%
Inhibition	=	29	%
Inhibition	=	87	%
Inhibition	=	74	%
Inhibition	=	95	%
Inhibition	=	0	%
Inhibition	=	53	%
Inhibition	=	25	%
Inhibition	=	0	%
Inhibition	=	32	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906446

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
PI	>	1.6
PI	>	1.6
PI	>	2.5
PI	>	1.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL658045

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2003
Volume: 13
Issue: 5
First Page: 837
Last Page: 840
DOI: 10.1016/s0960-894x(03)00028-3

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.012	Ki	=	12	nM
82	Ki	=	82000	nM
0.017	Ki	=	17	nM
0.021	Ki	=	21	nM
0.011	Ki	=	11	nM
0.027	Ki	=	27	nM
0.015	Ki	=	15	nM
0.012	Ki	=	12	nM
0.036	Ki	=	36	nM
0.049	Ki	=	49	nM
0.032	Ki	=	32	nM
0.021	Ki	=	21	nM
0.016	Ki	=	16	nM
0.012	Ki	=	12	nM
0.131	Ki	=	131	nM
100	Ki	>	100000	nM
0.148	Ki	=	148	nM
0.123	Ki	=	123	nM
0.89	Ki	=	890	nM
0.45	Ki	=	450	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL906477

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 16
First Page: 5604
Last Page: 5614
DOI: 10.1016/j.bmc.2007.05.024

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL662727

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2003
Volume: 13
Issue: 5
First Page: 837
Last Page: 840
DOI: 10.1016/s0960-894x(03)00028-3

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.9	Ki	=	900	nM
35	Ki	=	35000	nM
0.018	Ki	=	18	nM
0.023	Ki	=	23	nM
0.014	Ki	=	14	nM
0.149	Ki	=	149	nM
0.019	Ki	=	19	nM
0.013	Ki	=	13	nM
0.039	Ki	=	39	nM
0.062	Ki	=	62	nM
0.034	Ki	=	34	nM
0.017	Ki	=	17	nM
0.02	Ki	=	20	nM
0.016	Ki	=	16	nM
0.163	Ki	=	163	nM
100	Ki	>	100000	nM
0.155	Ki	=	155	nM
0.133	Ki	=	133	nM
0.96	Ki	=	960	nM
0.164	Ki	=	164	nM

14101-58-7 靶点实验数据