HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DNA topoisomerase 2-alpha

External ID: CHEMBL1176797

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5183
Last Page: 5193
DOI: 10.1016/j.bmc.2010.05.064

Target ChEMBL ID: CHEMBL1806
ChEMBL Target Name: DNA topoisomerase II alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL1176796

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5183
Last Page: 5193
DOI: 10.1016/j.bmc.2010.05.064

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Kapp	=	0.0075	10'-7/M
Kapp	=	1.19	10'-7/M

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL1176795

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5183
Last Page: 5193
DOI: 10.1016/j.bmc.2010.05.064

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.2	IC50	=	1200	nM
20	IC50	>	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HL-60

External ID: CHEMBL1176794

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5183
Last Page: 5193
DOI: 10.1016/j.bmc.2010.05.064

Target ChEMBL ID: CHEMBL383
ChEMBL Target Name: HL-60
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
20	IC50	>	20000	nM
11.8	IC50	=	11800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL1176793

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 14
First Page: 5183
Last Page: 5193
DOI: 10.1016/j.bmc.2010.05.064

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
20	IC50	>	20000	nM
8.3	IC50	=	8300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL998393

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 7
First Page: 967
Last Page: 969
DOI: 10.1021/np50085a021

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	3.46	ug ml-1
ED50	=	1.55	ug ml-1
ED50	=	2.49	ug ml-1
ED50	=	5.68	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL998392

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1992
Volume: 55
Issue: 7
First Page: 967
Last Page: 969
DOI: 10.1021/np50085a021

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	5.91	ug ml-1
ED50	=	1.44	ug ml-1
ED50	=	0.8	ug ml-1
ED50	=	3.23	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P2Y purinoceptor 12

External ID: CHEMBL995340

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 12
First Page: 3784
Last Page: 3793
DOI: 10.1021/jm9003297

Target ChEMBL ID: CHEMBL2001
ChEMBL Target Name: Purinergic receptor P2Y12
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
2.45	Ki	=	2450	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
1.85	Ki	=	1850	nM
10	Ki	>	10000	nM
6.76	Ki	=	6760	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
25.1	Ki	=	25100	nM
7.07	Ki	=	7070	nM
19.74	Ki	=	19740	nM
12.3	Ki	=	12300	nM
10	Ki	>	10000	nM
0.063	Ki	=	63	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P2Y purinoceptor 12

External ID: CHEMBL995341

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 12
First Page: 3784
Last Page: 3793
DOI: 10.1021/jm9003297

Target ChEMBL ID: CHEMBL2001
ChEMBL Target Name: Purinergic receptor P2Y12
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	-11	%	Outside typical range
Inhibition	=	5	%
Inhibition	=	7	%
Inhibition	=	2	%
Inhibition	=	1	%
Inhibition	=	30	%
Inhibition	=	2	%
Inhibition	=	4	%
Inhibition	=	25	%
Inhibition	=	50	%
Inhibition	=	4	%
Inhibition	=	2	%
Inhibition	=	4	%
Inhibition	=	7	%
Inhibition	=	13	%

14101-04-3 靶点实验数据