HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842658

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842657

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-46	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842656

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-42	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetyl-CoA acetyltransferase, mitochondrial

External ID: CHEMBL5515094

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 270
First Page: 116333
Last Page: 116333
DOI: 10.1016/j.ejmech.2024.116333

Target ChEMBL ID: CHEMBL2616
ChEMBL Target Name: Acetyl-CoA acetyltransferase, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.097	IC50	=	97	nM
0.183	IC50	=	183	nM
1.3	IC50	=	1300	nM
0.031	IC50	=	31	nM
0.059	IC50	=	59	nM
0.03	IC50	=	30	nM
0.113	IC50	=	113	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842655

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842662

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-36	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842661

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-44	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842660

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-27	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842659

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-36	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842664

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842663

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Change	<	-46	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL841906

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	1.5	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842676

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	1.1	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL622149

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Standard Type	Standard Relation	Standard Value
CLogP	=	10.4
CLogP	=	7.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842675

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	1.9	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842674

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	1.1	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL841910

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	1438	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL841909

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Reduction	=	776

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL841908

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	1.7	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL841907

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	2.8	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL843122

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	3.4	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sterol O-acyltransferase 1

External ID: CHEMBL5247064

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 14.0
First Page: 9786
Last Page: 9874
DOI: 10.1021/acs.jmedchem.1c00790

Target ChEMBL ID: CHEMBL2782
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.16	IC50	=	160	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL843121

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	4.6	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL843120

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	3	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL841911

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	857	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL842361

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	2.8	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL843124

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	4.4	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL843123

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Reduction	=	2.5	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acyl-CoA:cholesterol acyltransferase

External ID: CHEMBL641693

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 7
First Page: 1423
Last Page: 1432
DOI: 10.1021/jm9505876

Target ChEMBL ID: CHEMBL6141
ChEMBL Target Name: Acyl-CoA:cholesterol acyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.3	IC50	=	4300	nM
8.5	IC50	>	8500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acyl-CoA:cholesterol acyltransferase

External ID: CHEMBL649065

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 7
First Page: 1423
Last Page: 1432
DOI: 10.1021/jm9505876

Target ChEMBL ID: CHEMBL6141
ChEMBL Target Name: Acyl-CoA:cholesterol acyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.45	IC50	=	4450	nM
8.5	IC50	>	8500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sterol O-acyltransferase 1

External ID: CHEMBL641706

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 7
First Page: 1423
Last Page: 1432
DOI: 10.1021/jm9505876

Target ChEMBL ID: CHEMBL285
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.085	IC50	=	85	nM
0.25	IC50	=	250	nM
0.26	IC50	=	260	nM
0.11	IC50	=	110	nM
0.004	IC50	=	4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sterol O-acyltransferase 1

External ID: CHEMBL642358

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1995
Volume: 5
Issue: 2
First Page: 177
Last Page: 180
DOI: 10.1016/0960-894X(95)00003-C

Target ChEMBL ID: CHEMBL4464
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.88	IC50	=	880	nM
3.65	IC50	=	3650	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sterol O-acyltransferase 1

External ID: CHEMBL660744

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL285
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.014	IC50	=	14	nM
0.05	IC50	=	50	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acyl-CoA:cholesterol acyltransferase

External ID: CHEMBL662442

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1992
Volume: 2
Issue: 5
First Page: 375
Last Page: 380
DOI: 10.1016/S0960-894X(00)80149-3

Target ChEMBL ID: CHEMBL6141
ChEMBL Target Name: Acyl-CoA:cholesterol acyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	IC50	>	1000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sterol O-acyltransferase 1

External ID: CHEMBL646706

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1995
Volume: 5
Issue: 2
First Page: 177
Last Page: 180
DOI: 10.1016/0960-894X(95)00003-C

Target ChEMBL ID: CHEMBL285
ChEMBL Target Name: Acyl coenzyme A:cholesterol acyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.03	IC50	=	30	nM
0.75	IC50	=	750	nM

136609-26-2 靶点实验数据