HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL657971

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 25
First Page: 5471
Last Page: 5477
DOI: 10.1021/jm030911u

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.335	Ki	=	335	nM
1	Ki	>	1000	nM
1	Ki	>	1000	nM
1	Ki	>	1000	nM
0.386	Ki	=	386	nM
1	Ki	>	1000	nM
0.12	Ki	=	120	nM
1	Ki	>	1000	nM
1	Ki	>	1000	nM
1	Ki	>	1000	nM
1	Ki	>	1000	nM
0.126	Ki	=	126	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL657192

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 25
First Page: 5471
Last Page: 5477
DOI: 10.1021/jm030911u

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8	Ki	=	8000	nM
0.06	Ki	=	60	nM
10	Ki	>	10000	nM
0.57	Ki	=	570	nM
0.883	Ki	=	883	nM
10	Ki	>	10000	nM
0.129	Ki	=	129	nM
10	Ki	>	10000	nM
6	Ki	=	6000	nM
0.07	Ki	=	70	nM
0.75	Ki	=	750	nM
0.058	Ki	=	58	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL657832

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 25
First Page: 5471
Last Page: 5477
DOI: 10.1021/jm030911u

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
400	Ki	=	400000	nM	Outside typical range
59	Ki	=	59000	nM
1000	Ki	>	1000000	nM	Outside typical range
4.62	Ki	=	4620	nM
800	Ki	=	800000	nM	Outside typical range
1000	Ki	>	1000000	nM	Outside typical range
65	Ki	=	65000	nM
690	Ki	=	690000	nM	Outside typical range
40	Ki	=	40000	nM
3.1	Ki	=	3100	nM
3.7	Ki	=	3700	nM
0.71	Ki	=	710	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrases; II & IX

External ID: CHEMBL848914

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 25
First Page: 5471
Last Page: 5477
DOI: 10.1021/jm030911u

Target ChEMBL ID: CHEMBL2096906
ChEMBL Target Name: Carbonic anhydrases; II & IX
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	0.23
Ratio	=	0.51
Ratio	=	0.48
Ratio	=	23.88
Ratio	=	0.2
Ratio	=	1.84
Ratio	=	0.09
Ratio	=	1.11
Ratio	=	0.24
Ratio	=	0.46

136166-81-9 靶点实验数据