HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL3389997

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 20
First Page: 8540
Last Page: 8562
DOI: 10.1021/jm5010682

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.5	ug.mL-1
MIC	=	16	ug.mL-1
MIC	>	256	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	256	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	>	256	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	256	ug.mL-1
MIC	>	256	ug.mL-1
MIC	=	8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2645_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	Ki Qualifier	Ki	Target Accession(s)	Ligand	Target
Ki		0.02		20	Q9H3N8	BDBM22542	Histamine H4 receptor
Ki		0.016		16	Q9H3N8	BDBM22566	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22567	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22568	Histamine H4 receptor
Ki		0.794		794	Q9H3N8	BDBM22862	Histamine H4 receptor
Ki		1		1000	Q9H3N8	BDBM22863	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22864	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22865	Histamine H4 receptor
Ki		5.012		5012	Q9H3N8	BDBM22867	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22868	Histamine H4 receptor
Ki		0.2		200	Q9H3N8	BDBM22869	Histamine H4 receptor
Ki		5.012		5012	Q9H3N8	BDBM22870	Histamine H4 receptor
Ki		3.981		3981	Q9H3N8	BDBM22871	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22872	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22873	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22874	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22875	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22876	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22877	Histamine H4 receptor
Ki	>	10	>	10000	Q9H3N8	BDBM22879	Histamine H4 receptor

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3389999

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 20
First Page: 8540
Last Page: 8562
DOI: 10.1021/jm5010682

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
100	IC50	=	100000	nM
110	IC50	=	110000	nM	Outside typical range
110	IC50	=	110000	nM	Outside typical range
273	IC50	=	273000	nM	Outside typical range
333	IC50	>	333000	nM	Outside typical range
333	IC50	>	333000	nM	Outside typical range
333	IC50	>	333000	nM	Outside typical range
333	IC50	>	333000	nM	Outside typical range
147	IC50	=	147000	nM	Outside typical range
213	IC50	=	213000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DNA gyrase subunit B

External ID: CHEMBL3389998

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 20
First Page: 8540
Last Page: 8562
DOI: 10.1021/jm5010682

Target ChEMBL ID: CHEMBL3038482
ChEMBL Target Name: DNA gyrase
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
127	IC50	=	127000	nM	Outside typical range
410	IC50	=	410000	nM	Outside typical range
93	IC50	=	93000	nM
127	IC50	=	127000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
500	IC50	>	500000	nM	Outside typical range
93	IC50	=	93000	nM
90	IC50	=	90000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL741257

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2000
Volume: 43
Issue: 11
First Page: 2204
Last Page: 2216
DOI: 10.1021/jm990968+

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Permeability	Impermeable
Permeability
Permeability
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability	Impermeable
Permeability
Permeability
Permeability
Permeability
Permeability
Permeability
Permeability

126830-75-9 靶点实验数据