HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adrenergic receptor beta; ADRB1 & ADRB2

External ID: CHEMBL848336

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 1065
Last Page: 1080
DOI: 10.1021/jm00156a028

Target ChEMBL ID: CHEMBL2096974
ChEMBL Target Name: Adrenergic receptor beta; ADRB1 & ADRB2
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	11
Ratio	=	49
Ratio	=	0.56
Ratio	=	436
Ratio	=	407
Ratio	=	158
Ratio	=	234
Ratio	=	447
Ratio	=	0.46
Ratio	=	2692
Ratio	=	2754
Ratio	=	2630
Ratio	=	22
Ratio	=	2238

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-2 adrenergic receptor

External ID: CHEMBL651636

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 1065
Last Page: 1080
DOI: 10.1021/jm00156a028

Target ChEMBL ID: CHEMBL5414
ChEMBL Target Name: Beta-2 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.772E-4	Kd	=	0.9772	nM
4.36516	Kd	=	4365.16	nM
5.62341	Kd	=	5623.41	nM
8.51138	Kd	=	8511.38	nM
17.7828	Kd	=	17782.79	nM
0.19953	Kd	=	199.53	nM
40.738	Kd	=	40738.03	nM
1.54882	Kd	=	1548.82	nM
0.20893	Kd	=	208.93	nM
0.02455	Kd	=	24.55	nM
100	Kd	>	100000	nM
1.07152	Kd	=	1071.52	nM
0.83176	Kd	=	831.76	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-1 adrenergic receptor

External ID: CHEMBL650012

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 1065
Last Page: 1080
DOI: 10.1021/jm00156a028

Target ChEMBL ID: CHEMBL5471
ChEMBL Target Name: Beta-1 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.001738	Kd	=	1.738	nM
0.01862	Kd	=	18.62	nM
0.01288	Kd	=	12.88	nM
0.005129	Kd	=	5.129	nM
0.007586	Kd	=	7.586	nM
0.01905	Kd	=	19.05	nM
3.631E-4	Kd	=	0.3631	nM
0.0309	Kd	=	30.9	nM
0.01	Kd	=	10	nM
0.31623	Kd	>	316.23	nM
8.511E-4	Kd	=	0.8511	nM
0.01738	Kd	=	17.38	nM
0.006457	Kd	=	6.457	nM
9.333E-4	Kd	=	0.9333	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL635181

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 1065
Last Page: 1080
DOI: 10.1021/jm00156a028

Standard Type	Standard Relation	Standard Value
pKa	=	4.5
pKa	=	4.79
pKa	=	6.35
pKa	=	5.65
pKa	=	3.48
pKa	=	3.6
pKa	=	4
pKa	=	3.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-1 adrenergic receptor

External ID: CHEMBL654956

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1992
Volume: 35
Issue: 25
First Page: 4676
Last Page: 4682
DOI: 10.1021/jm00103a004

Target ChEMBL ID: CHEMBL5471
ChEMBL Target Name: Beta-1 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.001259	Kd	=	1.259	nM
0.1	Kd	=	100	nM
0.31623	Kd	=	316.23	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632358

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 1065
Last Page: 1080
DOI: 10.1021/jm00156a028

Standard Type	Standard Relation	Standard Value
LogD	=	60
LogD	=	25.5
LogD	=	9.3
LogD	=	0.27
LogD	=	40.4
LogD	=	5
LogD	=	19
LogD	=	79

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL790159

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 6
First Page: 1065
Last Page: 1080
DOI: 10.1021/jm00156a028

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Max increase	=	53
Max increase	=	42
Max increase	=	24
Max increase	=	19

123744-02-5 靶点实验数据