HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

External ID: CHEMBL4268853

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL4766
ChEMBL Target Name: Pyruvate dehydrogenase kinase isoform 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	19.7	%
Inhibition				Not Active
Inhibition				Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	19.7	%
Inhibition				Not Active
Inhibition	=	19.7	%
Inhibition				Not Active
Inhibition	=	44	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4268847

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	20.3	%
Inhibition	=	13.2	%
Inhibition	=	98.9	%
Inhibition	=	54.4	%
Inhibition	=	61.4	%
Inhibition	=	85.9	%
Inhibition	=	27.9	%
Inhibition	=	86.1	%
Inhibition	=	79.8	%
Inhibition	=	74.4	%
Inhibition	=	38.9	%
Inhibition	=	48.1	%
Inhibition	=	97.6	%
Inhibition				Not Active
Inhibition	=	17.5	%
Inhibition	=	31.5	%
Inhibition	=	79.8	%
Inhibition	=	91.2	%
Inhibition	=	48.8	%
Inhibition	=	6.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H1650

External ID: CHEMBL4268846

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL1075518
ChEMBL Target Name: NCI-H1650
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	60.5	%
Inhibition	=	15.3	%
Inhibition	=	11.8	%
Inhibition	=	25.5	%
Inhibition	=	10.3	%
Inhibition	=	32.5	%
Inhibition	=	21.4	%
Inhibition	=	29.3	%
Inhibition				Not Active
Inhibition	=	26.5	%
Inhibition	=	35	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	14.8	%
Inhibition	=	27.2	%
Inhibition	=	42.2	%
Inhibition	=	23.5	%
Inhibition				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4268849

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	52.3	%
Inhibition	=	9.2	%
Inhibition	=	8.5	%
Inhibition	=	13.4	%
Inhibition				Not Active
Inhibition	=	7.5	%
Inhibition	=	8.9	%
Inhibition	=	9.3	%
Inhibition				Not Active
Inhibition	=	4.7	%
Inhibition	=	24.5	%
Inhibition				Not Active
Inhibition	=	1.4	%
Inhibition	=	3.3	%
Inhibition	=	23.7	%
Inhibition	=	22.5	%
Inhibition				Not Active
Inhibition	=	1.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4268848

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	14.6	%
Inhibition	=	9.9	%
Inhibition	=	86.7	%
Inhibition	=	28.5	%
Inhibition	=	15.9	%
Inhibition	=	44.2	%
Inhibition	=	4.6	%
Inhibition	=	50.1	%
Inhibition	=	35.8	%
Inhibition	=	52.3	%
Inhibition	=	14.8	%
Inhibition	=	15.5	%
Inhibition	=	70.5	%
Inhibition				Not Active
Inhibition	=	6.1	%
Inhibition	=	15.3	%
Inhibition	=	62.2	%
Inhibition	=	75.9	%
Inhibition	=	16.2	%
Inhibition	=	4.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H1975

External ID: CHEMBL4268843

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL614348
ChEMBL Target Name: NCI-H1975
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	72.4	%
Inhibition	=	13.2	%
Inhibition	=	54.6	%
Inhibition	=	62.2	%
Inhibition	=	12.6	%
Inhibition	=	35.1	%
Inhibition	=	31.2	%
Inhibition	=	33.8	%
Inhibition				Not Active
Inhibition	=	15.4	%
Inhibition	=	77.8	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	15.9	%
Inhibition	=	39.8	%
Inhibition	=	56.3	%
Inhibition	=	13.3	%
Inhibition	=	4.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H1975

External ID: CHEMBL4268842

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL614348
ChEMBL Target Name: NCI-H1975
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	21.6	%
Inhibition	=	19.5	%
Inhibition	=	90.6	%
Inhibition	=	54.3	%
Inhibition	=	99.4	%
Inhibition	=	98.5	%
Inhibition	=	39	%
Inhibition	=	95.8	%
Inhibition	=	58.6	%
Inhibition	=	91.4	%
Inhibition	=	27.7	%
Inhibition	=	92.1	%
Inhibition	=	99.6	%
Inhibition				Not Active
Inhibition	=	14.3	%
Inhibition	=	73.1	%
Inhibition	=	69.8	%
Inhibition	=	90.3	%
Inhibition	=	67.7	%
Inhibition	=	61.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H1650

External ID: CHEMBL4268845

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL1075518
ChEMBL Target Name: NCI-H1650
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	15.5	%
Inhibition	=	14.5	%
Inhibition	=	86.9	%
Inhibition	=	31.3	%
Inhibition	=	65.8	%
Inhibition	=	82.1	%
Inhibition	=	19.7	%
Inhibition	=	56.8	%
Inhibition	=	48.9	%
Inhibition	=	65.6	%
Inhibition	=	24.8	%
Inhibition	=	62.9	%
Inhibition	=	98.5	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	39.6	%
Inhibition	=	46.7	%
Inhibition	=	79.2	%
Inhibition	=	37.8	%
Inhibition	=	22.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H1650

External ID: CHEMBL4268844

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL1075518
ChEMBL Target Name: NCI-H1650
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	21.3	%
Inhibition	=	15.4	%
Inhibition	=	99.6	%
Inhibition	=	47.9	%
Inhibition	=	96.5	%
Inhibition	=	99.9	%
Inhibition	=	42.9	%
Inhibition	=	84.9	%
Inhibition	=	85.7	%
Inhibition	=	99.6	%
Inhibition	=	51.4	%
Inhibition	=	95.5	%
Inhibition	=	99.9	%
Inhibition				Not Active
Inhibition	=	0.4	%
Inhibition	=	90.5	%
Inhibition	=	69.6	%
Inhibition	=	96.4	%
Inhibition	=	73.4	%
Inhibition	=	49.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H1975

External ID: CHEMBL4268841

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 21
First Page: 3441
Last Page: 3445
DOI: 10.1016/j.bmcl.2018.09.026

Target ChEMBL ID: CHEMBL614348
ChEMBL Target Name: NCI-H1975
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	30.2	%
Inhibition	=	22.9	%
Inhibition	=	98.6	%
Inhibition	=	83.7	%
Inhibition	=	99.7	%
Inhibition	=	99.9	%
Inhibition	=	71	%
Inhibition	=	98.3	%
Inhibition	=	94.5	%
Inhibition	=	96.8	%
Inhibition	=	85.6	%
Inhibition	=	98.3	%
Inhibition	=	99.4	%
Inhibition				Not Active
Inhibition	=	49.5	%
Inhibition	=	98.5	%
Inhibition	=	93	%
Inhibition	=	99.4	%
Inhibition	=	96.1	%
Inhibition	=	93.7	%

121069-00-9 靶点实验数据