HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL891104

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 5
First Page: 2006
Last Page: 2015
DOI: 10.1016/j.bmc.2006.12.038

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
39810700	IC50	=	3.981071705535E10	nM	Outside typical range
5750	IC50	=	5750000	nM	Outside typical range
173780000	IC50	=	1.7378008287494E11	nM	Outside typical range
3120	IC50	=	3120000	nM	Outside typical range
323594000	IC50	=	3.2359365692963E11	nM	Outside typical range
50500	IC50	=	50500000	nM	Outside typical range
19952600	IC50	=	1.995262314969E10	nM	Outside typical range
14200	IC50	=	14200000	nM	Outside typical range
70794600	IC50	=	7.079457843841E10	nM	Outside typical range
16250	IC50	=	16250000	nM	Outside typical range
61659500	IC50	=	6.165950018615E10	nM	Outside typical range
5900	IC50	=	5900000	nM	Outside typical range
169824000	IC50	=	1.6982436524617E11	nM	Outside typical range
5550	IC50	=	5550000	nM	Outside typical range
181970000	IC50	=	181970085861	nM	Outside typical range
42880	IC50	=	42880000	nM	Outside typical range
23442300	IC50	=	2.34422881532E10	nM	Outside typical range
13300	IC50	=	13300000	nM	Outside typical range
75857800	IC50	=	7.585775750292E10	nM	Outside typical range
29500	IC50	=	29500000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789851

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	11.2
FC	=	2.6
FC	=	9.8
FC	=	11.2
FC	=	9.8
FC	=	9.8
FC	=	2.6
FC	=	2.6
FC	=	2.6
FC	=	8
FC	=	2.1
FC	=	9.8
FC	=	2.1
FC	=	4.9
FC	=	4.9
FC	=	11.2
FC	=	8
FC	=	2.6
FC	=	8
FC	=	9.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789850

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	25	ug
LD50	=	6	ug
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	25	ug
LD50				Not Active
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50	=	22	ug
LD50				Not Active
LD50				Not Active
LD50	=	6	ug
LD50	=	6	ug
LD50	=	6	ug
LD50	=	18	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789855

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789854

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MHC	=	10	ug
MHC	=	50	ug
MHC	=	15	ug
MHC	=	20	ug
MHC	=	20	ug
MHC	=	10	ug
MHC				Not Active
MHC	=	10	ug
MHC	=	15	ug
MHC	=	10	ug
MHC	=	25	ug
MHC	=	30	ug
MHC				Not Active
MHC	=	50	ug
MHC	=	15	ug
MHC				Not Active
MHC	=	60	ug
MHC	=	30	ug
MHC	=	50	ug
MHC	=	10	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789853

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789852

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	9	ug
LD50	=	3	ug
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50	=	9	ug
LD50				Not Active
LD50				Not Active
LD50	=	3	ug
LD50	=	3	ug
LD50	=	3	ug
LD50	=	6	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL1012121

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1989
Volume: 52
Issue: 6
First Page: 1252
Last Page: 1257
DOI: 10.1021/np50066a009

Target ChEMBL ID: CHEMBL3608
ChEMBL Target Name: Epidermal growth factor receptor erbB1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	2.7	ug.mL-1
IC50	=	0.2	ug.mL-1
IC50	=	0.0044	ug.mL-1
IC50	=	0.012	ug.mL-1
IC50	>	100	ug.mL-1	Outside typical range
IC50	=	33	ug.mL-1
IC50	=	0.49	ug.mL-1
IC50	=	0.011	ug.mL-1
IC50	=	0.35	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Myeloperoxidase

External ID: CHEMBL3877132

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2017
Volume: 8
Issue: 2
First Page: 206
Last Page: 210
DOI: 10.1021/acsmedchemlett.6b00417

Target ChEMBL ID: CHEMBL2439
ChEMBL Target Name: Myeloperoxidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	61	%
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition	=	61	%
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789859

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50	=	10	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	8	ug
LD50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789858

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	3.75
FC	=	1.25
FC	=	3.75
FC	=	2.5
FC	=	3.75
FC	=	1.25
FC	=	3.75
FC	=	1.25
FC	=	1.25
FC	=	2.5
FC	=	2.5
FC	=	1.25
FC	=	2.5
FC	=	2.5
FC	=	2.5
FC	=	3.75
FC	=	3.75
FC	=	1.25
FC	=	2.5
FC	=	3.75

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789857

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
LD50				Not Active
LD50	=	150	ug
LD50	=	50	ug
LD50				Not Active
LD50	=	150	ug
LD50				Not Active
LD50				Not Active
LD50				Not Active
LD50	=	100	ug
LD50				Not Active
LD50				Not Active
LD50	=	150	ug
LD50	=	50	ug
LD50	=	150	ug
LD50				Not Active
LD50				Not Active
LD50	=	50	ug
LD50	=	50	ug
LD50	=	100	ug
LD50	=	100	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789856

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
LogP	=	1.24
LogP	=	0.97
LogP	=	2.39
LogP	=	1.15
LogP	=	1.48
LogP	=	1.87
LogP	=	1.76
LogP	=	1.47
LogP	=	1.44
LogP	=	1.15
LogP	=	1.48
LogP	=	1.48
LogP	=	1.47
LogP	=	3.19
LogP	=	1.19
LogP	=	1.47
LogP	=	2
LogP	=	1.15
LogP	=	1.19
LogP	=	1.15

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789862

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3789861

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 114
First Page: 209
Last Page: 219
DOI: 10.1016/j.ejmech.2016.03.008

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MHC	=	10	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	5	ug
MHC	=	5	ug
MHC				Not Active
MHC	=	5	ug
MHC	=	5	ug
MHC	=	10	ug
MHC	=	15	ug
MHC	=	5	ug
MHC	=	10	ug
MHC	=	10	ug
MHC	=	5	ug
MHC				Not Active
MHC	=	20	ug
MHC	=	15	ug
MHC	=	5	ug
MHC	=	5	ug

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania donovani

External ID: CHEMBL3371121

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2014
Volume: 77
Issue: 9
First Page: 1987
Last Page: 1991
DOI: 10.1021/np5000473

Target ChEMBL ID: CHEMBL367
ChEMBL Target Name: Leishmania donovani
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.4	IC90	=	400	nM
9.2	IC50	=	9200	nM
12.4	IC90	=	12400	nM
3.3	IC50	=	3300	nM
6.1	IC90	=	6100	nM
8.5	IC50	=	8500	nM
10.4	IC90	=	10400	nM
13	IC50	=	13000	nM
22	IC90	=	22000	nM
6.9	IC50	=	6900	nM
61	IC90	=	61000	nM
34	IC50	=	34000	nM

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2

1194-98-5 靶点实验数据

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	10
FC	=	3
FC	=	4
FC	=	4
FC	=	2
FC	=	2
FC	=	3
FC	=	2
FC	=	5
FC	=	6
FC	=	10
FC	=	3
FC	=	12
FC	=	6
FC	=	10
FC	=	2
FC	=	7
FC	=	5
FC	=	8

Standard Type	Standard Relation	Standard Value
FC	=	3.2
FC	=	1
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	3.2
FC	=	1
FC	=	1
FC	=	1
FC	=	2.1
FC	=	1
FC	=	3.2
FC	=	1
FC	=	1
FC	=	2.1
FC	=	3.2
FC	=	2.1
FC	=	1
FC	=	2.1
FC	=	3.2

Standard Type	Standard Relation	Standard Value
FC	=	2
FC	=	2
FC	=	2
FC	=	2
FC	=	1
FC	=	1
FC	=	1
FC	=	1
FC	=	2
FC	=	3
FC	=	1
FC	=	2
FC	=	2
FC	=	1
FC	=	4
FC	=	3
FC	=	1
FC	=	1
FC	=	3
FC	=	2