HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4880078

Protocol: N/A

Comment: Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Activity Comment
fluorescence	=	1.2	Not Active
fluorescence	=	2	Not Active
fluorescence	=	1.4	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	2	Active
fluorescence	=	0.5	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.6	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	5.4	Active
fluorescence	=	0.8	Not Active
fluorescence	=	1.2	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.7	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	3.4	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4880077

Protocol: N/A

Comment: Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Activity Comment
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4880076

Protocol: N/A

Comment: Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Activity Comment
fluorescence	=	1.1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active
fluorescence	=	1	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4880075

Protocol: N/A

Comment: Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Activity Comment
fluorescence	=	1.1	Not Active
fluorescence	=	1.1	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.7	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	0.8	Not Active
fluorescence	=	1.2	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	0.9	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4880079

Protocol: N/A

Comment: Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Activity Comment
fluorescence	=	0.9	Not Active
fluorescence	=	1.7	Not Active
fluorescence	=	3.3	Active
fluorescence	=	0.4	Not Active
fluorescence	=	2.5	Active
fluorescence	=	0.4	Not Active
fluorescence	=	0.7	Not Active
fluorescence	=	0.6	Not Active
fluorescence	=	0.6	Not Active
fluorescence	=	1.2	Not Active
fluorescence	=	0.7	Not Active
fluorescence	=	0.7	Not Active
fluorescence	=	1.8	Active
fluorescence	=	0.5	Not Active
fluorescence	=	1	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	1.9	Not Active
fluorescence	=	0.7	Not Active
fluorescence	=	0.9	Not Active
fluorescence	=	3.7	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1F

External ID: CHEMBL4883179

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4524122
ChEMBL Target Name: Serotonin 1 (5-HT1) receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	0	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-3 adrenergic receptor

External ID: CHEMBL4883178

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL246
ChEMBL Target Name: Beta-3 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	-6	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-2 adrenergic receptor

External ID: CHEMBL4883177

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL210
ChEMBL Target Name: Beta-2 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	4	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-1 adrenergic receptor

External ID: CHEMBL4883176

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL213
ChEMBL Target Name: Beta-1 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	-5	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 15

External ID: CHEMBL4879707

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL5198
ChEMBL Target Name: Mitogen-activated protein kinase 15
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	94	%	Not Active
% Control	=	83	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	98	%	Not Active
% Control	=	92	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	74	%	Not Active
% Control	=	82.4	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	91	%	Not Active
% Control	=	93	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-2A adrenergic receptor

External ID: CHEMBL4883173

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1867
ChEMBL Target Name: Alpha-2a adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	5	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 6

External ID: CHEMBL4879704

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5121
ChEMBL Target Name: Mitogen-activated protein kinase 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	90	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	97	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	71	%	Not Active
% Control	=	95	%	Not Active
% Control	=	88	%	Not Active
% Control	=	99.9	%	Not Active
% Control	=	94	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Insulin receptor-related protein

External ID: CHEMBL4879756

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5483
ChEMBL Target Name: Insulin receptor-related protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	97	%	Not Active
% Control	=	100	%	Not Active
% Control	=	94	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	97	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	77	%	Not Active
% Control	=	98	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	95	%	Not Active
% Control	=	91	%	Not Active
% Control	=	67	%	Not Active
% Control	=	100	%	Not Active
% Control	=	90	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase WNK2

External ID: CHEMBL4880012

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5639
ChEMBL Target Name: Serine/threonine-protein kinase WNK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	60.2	%	Not Active
% Control	=	58	%	Not Active
% Control	=	95	%	Not Active
% Control	=	92	%	Not Active
% Control	=	77	%	Not Active
% Control	=	92	%	Not Active
% Control	=	79	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	74	%	Not Active
% Control	=	85	%	Not Active
% Control	=	70	%	Not Active
% Control	=	98	%	Not Active
% Control	=	100	%	Not Active
% Control	=	94	%	Not Active
% Control	=	96	%	Not Active
% Control	=	84	%	Not Active
% Control	=	54.2	%	Not Active
% Control	=	96	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1D adrenergic receptor

External ID: CHEMBL3801620

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL223
ChEMBL Target Name: Alpha-1d adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0037	Ki	=	3.7	nM
0.16	Ki	=	160	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2

External ID: CHEMBL3801624

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	25	%
Inhibition	=	47	%
Inhibition	=	16	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3801623

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	11
Ratio Ki	>	750
Ratio Ki	=	800

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3801622

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	0.7
Ratio Ki	>	1700
Ratio Ki	=	200

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801628

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	4.676	L.kg-1
Vdss	=	4.432	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Non-receptor tyrosine-protein kinase TYK2

External ID: CHEMBL4880001

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3553
ChEMBL Target Name: Tyrosine-protein kinase TYK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	85.9	%	Not Active
% Control	=	80	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	86	%	Not Active
% Control	=	100	%	Not Active
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	95	%	Not Active
% Control	=	91	%	Not Active
% Control	=	94	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	87	%	Not Active
% Control	=	89	%	Not Active
% Control	=	100	%	Not Active
% Control	=	79.8	%	Not Active
% Control	=	75	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：eIF-2-alpha kinase GCN2

External ID: CHEMBL4879734

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5358
ChEMBL Target Name: Eukaryotic translation initiation factor 2-alpha kinase 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	65	%	Not Active
% Control	=	100	%	Not Active
% Control	=	90	%	Not Active
% Control	=	48	%	Slightly Active
% Control	=	78	%	Not Active
% Control	=	100	%	Not Active
% Control	=	87	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	54	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	94	%	Not Active
% Control	=	73	%	Not Active
% Control	=	100	%	Not Active
% Control	=	27	%	Slightly Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	83	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 6

External ID: CHEMBL4879995

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1628470
ChEMBL Target Name: Transient receptor potential cation channel subfamily M member 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	86	%	Not Active
% Control	=	78	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	83.8	%	Not Active
% Control	=	94.8	%	Not Active
% Control	=	64	%	Not Active
% Control	=	83	%	Not Active
% Control	=	52	%	Not Active
% Control	=	80.2	%	Not Active
% Control	=	84	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	82	%	Not Active
% Control	=	64	%	Not Active
% Control	=	92	%	Not Active
% Control	=	87	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 2

External ID: CHEMBL4879795

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5330
ChEMBL Target Name: Mitogen-activated protein kinase kinase kinase kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	54.4	%	Not Active
% Control	=	79	%	Not Active
% Control	=	92	%	Not Active
% Control	=	87	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	81	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	96	%	Not Active
% Control	=	84	%	Not Active
% Control	=	85	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	69	%	Not Active
% Control	=	100	%	Not Active
% Control	=	83	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL4880043

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL236
ChEMBL Target Name: Delta opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	Inhibition	=	-10.72	%	Not Active	Outside typical range
	Inhibition	=	20.01	%	Not Active
	Inhibition	=	12.26	%	Not Active
	Inhibition	=	20.04	%	Not Active
	Inhibition	=	-20.87	%	Not Active	Outside typical range
	Inhibition	=	36.37	%	Not Active
	Inhibition	=	-17.53	%	Not Active	Outside typical range
	Inhibition	=	-9.42	%	Not Active
	Inhibition	=	0.8	%	Not Active
	Inhibition	=	-12.09	%	Not Active	Outside typical range
	Inhibition	=	7.84	%	Not Active
	Inhibition	=	-0.84	%	Not Active
	Inhibition	=	10.29	%	Not Active
	Inhibition	=	-5.348	%	Not Active
0.0475	Ki	=	47.5	nM
0.04467	Ki	=	44.67	nM
	Inhibition	=	-32.27	%	Not Active	Outside typical range
	Inhibition	=	-0.28	%	Not Active
	Inhibition	=	7.96	%	Not Active
	Inhibition	=	5.07	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leukocyte tyrosine kinase receptor

External ID: CHEMBL4879786

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5627
ChEMBL Target Name: Leukocyte tyrosine kinase receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	74	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	81	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	89	%	Not Active
% Control	=	99	%	Not Active
% Control	=	100	%	Not Active
% Control	=	70.6	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801632

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	3.14	hr
MRT	=	4.53	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801631

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	368	ng.hr.mL-1
AUC	=	358	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801629

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	39.17	mL.min-1.kg-1
CL	=	39.92	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801636

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MED	=	10	ug/kg
MED	=	10	ug/kg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801635

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ID50	=	0.0044	mg.kg-1
Inhibition				Dose-dependent effect
ID50	=	0.0013	mg.kg-1
Inhibition				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Urinary bladder

External ID: CHEMBL3801634

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL5169291
ChEMBL Target Name: Urinary bladder
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Inhibition				Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3801633

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2016
Volume: 59
Issue: 7
First Page: 2989
Last Page: 3002
DOI: 10.1021/acs.jmedchem.5b01528

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	86	%
F	=	84.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL4880023

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	18.29	%	Not Active
Inhibition	=	20.19	%	Not Active
Inhibition	=	-10.61	%	Not Active	Outside typical range
Inhibition	=	21.04	%	Not Active
Inhibition	=	11.25	%	Not Active
Inhibition	=	19.51	%	Not Active
Inhibition	=	-13.46	%	Not Active	Outside typical range
Inhibition	=	22.66	%	Not Active
Inhibition	=	1.37	%	Not Active
Inhibition	=	22.87	%	Not Active
Inhibition	=	26.72	%	Not Active
Inhibition	=	40.51	%	Not Active
Inhibition	=	-5.214	%	Not Active
Inhibition	=	18.5	%	Not Active
Inhibition	=	-9.76	%	Not Active
Inhibition	=	11.74	%	Not Active
Inhibition	=	-22.74	%	Not Active	Outside typical range
Inhibition	=	7.698	%	Not Active
Inhibition	=	15.83	%	Not Active
Inhibition	=	5.18	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 19

External ID: CHEMBL4880020

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL6191
ChEMBL Target Name: SPS1/STE20-related protein kinase YSK4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	90.3	%	Not Active
% Control	=	77	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	84	%	Not Active
% Control	=	85	%	Not Active
% Control	=	77	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	69	%	Not Active
% Control	=	75	%	Not Active
% Control	=	85	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	1.7	%	Active
% Control	=	74	%	Not Active
% Control	=	82	%	Not Active
% Control	=	79.2	%	Not Active
% Control	=	95	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3

External ID: CHEMBL4879764

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2148
ChEMBL Target Name: Tyrosine-protein kinase JAK3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	71.3	%	Not Active
% Control	=	84	%	Not Active
% Control	=	100	%	Not Active
% Control	=	98	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	95	%	Not Active
% Control	=	100	%	Not Active
% Control	=	98	%	Not Active
% Control	=	100	%	Not Active
% Control	=	82	%	Not Active
% Control	=	65	%	Not Active
% Control	=	100	%	Not Active
% Control	=	93	%	Not Active
% Control	=	8.2	%	Active
% Control	=	92	%	Not Active
% Control	=	100	%	Not Active
% Control	=	78.4	%	Not Active
% Control	=	58	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1E

External ID: CHEMBL4880026

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL2182
ChEMBL Target Name: Serotonin 1e (5-HT1e) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
Inhibition	=	35.8	%	Not Active
Inhibition	=	-8.31	%	Not Active
Inhibition	=	18.99	%	Not Active
Inhibition	=	5.505	%	Not Active
Inhibition	=	-10.11	%	Not Active	Outside typical range
Inhibition	=	13.38	%	Not Active
Inhibition	=	-3.141	%	Not Active
Inhibition	=	6.37	%	Not Active
Inhibition	=	10.34	%	Not Active
Inhibition	=	3.83	%	Not Active
Inhibition	=	-16.23	%	Not Active	Outside typical range
Inhibition	=	-3.26	%	Not Active
Inhibition	=	18.81	%	Not Active
Inhibition	=	-9.586	%	Not Active
Inhibition	=	24.15	%	Not Active
Inhibition	=	18.19	%	Not Active
Inhibition	=	-31.19	%	Not Active	Outside typical range
Inhibition	=	10.97	%	Not Active
Inhibition	=	-0.1791	%	Not Active
Inhibition	=	-0.6879	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879567

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	80.7	%	Not Active
% Control	=	77	%	Not Active
% Control	=	100	%	Not Active
% Control	=	98	%	Not Active
% Control	=	85	%	Not Active
% Control	=	76	%	Not Active
% Control	=	91	%	Not Active
% Control	=	100	%	Not Active
% Control	=	87	%	Not Active
% Control	=	89	%	Not Active
% Control	=	92	%	Not Active
% Control	=	71	%	Not Active
% Control	=	95	%	Not Active
% Control	=	100	%	Not Active
% Control	=	45	%	Slightly Active
% Control	=	84	%	Not Active
% Control	=	84	%	Not Active
% Control	=	77.5	%	Not Active
% Control	=	92	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879566

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	58	%	Not Active
% Control	=	89	%	Not Active
% Control	=	88	%	Not Active
% Control	=	90	%	Not Active
% Control	=	100	%	Not Active
% Control	=	80	%	Not Active
% Control	=	74	%	Not Active
% Control	=	79	%	Not Active
% Control	=	86	%	Not Active
% Control	=	83	%	Not Active
% Control	=	73	%	Not Active
% Control	=	95	%	Not Active
% Control	=	75	%	Not Active
% Control	=	93	%	Not Active
% Control	=	80	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	51	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879565

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	97.7	%	Not Active
% Control	=	86	%	Not Active
% Control	=	72	%	Not Active
% Control	=	85	%	Not Active
% Control	=	84	%	Not Active
% Control	=	99	%	Not Active
% Control	=	72	%	Not Active
% Control	=	90	%	Not Active
% Control	=	87	%	Not Active
% Control	=	78	%	Not Active
% Control	=	81	%	Not Active
% Control	=	77	%	Not Active
% Control	=	100	%	Not Active
% Control	=	81	%	Not Active
% Control	=	100	%	Not Active
% Control	=	91	%	Not Active
% Control	=	94	%	Not Active
% Control	=	91.4	%	Not Active
% Control	=	94	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879564

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	61	%	Not Active
% Control	=	100	%	Not Active
% Control	=	96	%	Not Active
% Control	=	95	%	Not Active
% Control	=	75	%	Not Active
% Control	=	89	%	Not Active
% Control	=	100	%	Not Active
% Control	=	77	%	Not Active
% Control	=	72	%	Not Active
% Control	=	92	%	Not Active
% Control	=	71	%	Not Active
% Control	=	79	%	Not Active
% Control	=	74	%	Not Active
% Control	=	98	%	Not Active
% Control	=	85	%	Not Active
% Control	=	90	%	Not Active
% Control	=	86.4	%	Not Active
% Control	=	88	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL2

External ID: CHEMBL4879571

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4014
ChEMBL Target Name: Tyrosine-protein kinase ABL2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	99	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	93	%	Not Active
% Control	=	86	%	Not Active
% Control	=	100	%	Not Active
% Control	=	82.2	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879570

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	79.8	%	Not Active
% Control	=	73	%	Not Active
% Control	=	81	%	Not Active
% Control	=	84	%	Not Active
% Control	=	87	%	Not Active
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	75	%	Not Active
% Control	=	96	%	Not Active
% Control	=	72	%	Not Active
% Control	=	94	%	Not Active
% Control	=	62	%	Not Active
% Control	=	89	%	Not Active
% Control	=	68	%	Not Active
% Control	=	100	%	Not Active
% Control	=	97	%	Not Active
% Control	=	100	%	Not Active
% Control	=	68.6	%	Not Active
% Control	=	93	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879569

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	80	%	Not Active
% Control	=	96.5	%	Not Active
% Control	=	70	%	Not Active
% Control	=	85	%	Not Active
% Control	=	100	%	Not Active
% Control	=	88	%	Not Active
% Control	=	68	%	Not Active
% Control	=	98	%	Not Active
% Control	=	72	%	Not Active
% Control	=	76	%	Not Active
% Control	=	85	%	Not Active
% Control	=	81	%	Not Active
% Control	=	65	%	Not Active
% Control	=	93	%	Not Active
% Control	=	60	%	Not Active
% Control	=	88	%	Not Active
% Control	=	89	%	Not Active
% Control	=	78	%	Not Active
% Control	=	85	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879568

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	86.7	%	Not Active
% Control	=	75	%	Not Active
% Control	=	96	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	72	%	Not Active
% Control	=	73	%	Not Active
% Control	=	95	%	Not Active
% Control	=	81	%	Not Active
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	93	%	Not Active
% Control	=	100	%	Not Active
% Control	=	81	%	Not Active
% Control	=	100	%	Not Active
% Control	=	84.6	%	Not Active
% Control	=	93	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879559

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	62	%	Not Active
% Control	=	100	%	Not Active
% Control	=	89	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	57	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	86	%	Not Active
% Control	=	61	%	Not Active
% Control	=	87	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	84	%	Not Active
% Control	=	100	%	Not Active
% Control	=	78.7	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879558

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	72.5	%	Not Active
% Control	=	71	%	Not Active
% Control	=	94	%	Not Active
% Control	=	82	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	81	%	Not Active
% Control	=	100	%	Not Active
% Control	=	87	%	Not Active
% Control	=	81	%	Not Active
% Control	=	84	%	Not Active
% Control	=	100	%	Not Active
% Control	=	96	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	55	%	Not Active
% Control	=	100	%	Not Active
% Control	=	62.4	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879557

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	98.5	%	Not Active
% Control	=	76	%	Not Active
% Control	=	77	%	Not Active
% Control	=	79	%	Not Active
% Control	=	84	%	Not Active
% Control	=	100	%	Not Active
% Control	=	65	%	Not Active
% Control	=	100	%	Not Active
% Control	=	76	%	Not Active
% Control	=	86	%	Not Active
% Control	=	80	%	Not Active
% Control	=	68	%	Not Active
% Control	=	92	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	92	%	Not Active
% Control	=	96.4	%	Not Active
% Control	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879556

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	83.7	%	Not Active
% Control	=	70	%	Not Active
% Control	=	94	%	Not Active
% Control	=	90	%	Not Active
% Control	=	100	%	Not Active
% Control	=	85	%	Not Active
% Control	=	100	%	Not Active
% Control	=	87	%	Not Active
% Control	=	100	%	Not Active
% Control	=	75	%	Not Active
% Control	=	88	%	Not Active
% Control	=	65	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	83	%	Not Active
% Control	=	85	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879563

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	96.9	%	Not Active
% Control	=	69	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	99	%	Not Active
% Control	=	57	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	94	%	Not Active
% Control	=	90	%	Not Active
% Control	=	75	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	83	%	Not Active
% Control	=	87	%	Not Active
% Control	=	84.4	%	Not Active
% Control	=	91	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1

External ID: CHEMBL4879562

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1862
ChEMBL Target Name: Tyrosine-protein kinase ABL
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Control	=	100	%	Not Active
% Control	=	96.1	%	Not Active
% Control	=	81	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	91	%	Not Active
% Control	=	86	%	Not Active
% Control	=	92	%	Not Active
% Control	=	88	%	Not Active
% Control	=	85	%	Not Active
% Control	=	84	%	Not Active
% Control	=	86	%	Not Active
% Control	=	100	%	Not Active
% Control	=	100	%	Not Active
% Control	=	95	%	Not Active
% Control	=	99	%	Not Active
% Control	=	83.6	%	Not Active
% Control	=	99	%	Not Active

1191908-24-3 靶点实验数据