HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4809354

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 9.0
First Page: 5632
Last Page: 5644
DOI: 10.1021/acs.jmedchem.0c02124

Standard Type	Activity Comment
Activity	Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4825257

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2021
Volume: 46
First Page: 116364
Last Page: 116364
DOI: 10.1016/j.bmc.2021.116364

Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.23	EC50	=	230	nM
0.11	EC50	=	110	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL5336305

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.39	EC50	=	390	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5336299

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	>	1282

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4825255

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2021
Volume: 46
First Page: 116364
Last Page: 116364
DOI: 10.1016/j.bmc.2021.116364

Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	99	%
Inhibition	=	65	%
Inhibition	=	99	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5336300

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Yellow fever virus

External ID: CHEMBL2020510

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL613731
ChEMBL Target Name: Yellow fever virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	EC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：dengue virus type 2

External ID: CHEMBL2020511

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL613966
ChEMBL Target Name: dengue virus type 2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5336289

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	13	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL2020509

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
39	EC50	=	39000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5336290

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Standard Type	Standard Relation	Standard Value
Fu	=	0.62

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5336287

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	16	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5336288

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 257
First Page: 115503
Last Page: 115503
DOI: 10.1016/j.ejmech.2023.115503

Standard Type	Standard Relation	Standard Value	Standard Units
F	<	8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fibroblast

External ID: CHEMBL4809334

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 9.0
First Page: 5632
Last Page: 5644
DOI: 10.1021/acs.jmedchem.0c02124

Target ChEMBL ID: CHEMBL5314315
ChEMBL Target Name: Fibroblast
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.4	CC50	=	2400	nM
17	CC50	=	17000	nM
9.3	CC50	=	9300	nM
10	CC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4809335

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 9.0
First Page: 5632
Last Page: 5644
DOI: 10.1021/acs.jmedchem.0c02124

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	>	44
Ratio CC50/EC50	=	76

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4809332

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 9.0
First Page: 5632
Last Page: 5644
DOI: 10.1021/acs.jmedchem.0c02124

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.092	EC50	=	92	nM
2.5	EC50	=	2500	nM
2.2	EC50	=	2200	nM
1.9	EC50	=	1900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4809333

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 9.0
First Page: 5632
Last Page: 5644
DOI: 10.1021/acs.jmedchem.0c02124

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	EC50	=	100	nM
2.4	EC50	=	2400	nM
0.88	EC50	=	880	nM
1.6	EC50	=	1600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MRC5

External ID: CHEMBL2020522

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL614181
ChEMBL Target Name: MRC5
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	CC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5324153

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 17
First Page: 11701
Last Page: 11717
DOI: 10.1021/acs.jmedchem.3c00750

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDCK

External ID: CHEMBL2020523

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL614068
ChEMBL Target Name: MDCK
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	CC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL5324154

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 17
First Page: 11701
Last Page: 11717
DOI: 10.1021/acs.jmedchem.3c00750

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL2020520

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	CC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824009

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
Drug metabolism	=	1.1	pmol
Drug metabolism	=	6.54	pmol

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7

External ID: CHEMBL2020521

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL614039
ChEMBL Target Name: Huh-7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
45	CC50	>	45000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7

External ID: CHEMBL2020525

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL614039
ChEMBL Target Name: Huh-7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
5.08E-5	Cmax	=	0.0508	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human respirovirus 3

External ID: CHEMBL2020514

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL613126
ChEMBL Target Name: Human respirovirus 3
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Respiratory syncytial virus

External ID: CHEMBL4824003

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Target ChEMBL ID: CHEMBL612679
ChEMBL Target Name: Respiratory syncytial virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.42	EC50	=	420	nM
2.5	EC50	=	2500	nM
5	EC50	>	5000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome-related coronavirus

External ID: CHEMBL2020515

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL4303836
ChEMBL Target Name: SARS-CoV
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
14	EC50	=	14000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824004

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value
Ratio EC50	=	8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：West Nile virus

External ID: CHEMBL2020512

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL613730
ChEMBL Target Name: West Nile virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824001

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	3.4	%
F	<	1	%
F	=	28	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Influenza A virus

External ID: CHEMBL2020513

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL613740
ChEMBL Target Name: Influenza A virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824002

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value
Ratio CC50/EC50	>	189
Ratio CC50/EC50	=	407
Ratio CC50/EC50	>	277

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL2020518

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	CC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824007

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
Drug metabolism	=	2	pmol
Drug metabolism	=	22	pmol

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL2020519

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	CC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824008

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
Drug metabolism	=	0.9	pmol
Drug metabolism	=	20.5	pmol

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL2020516

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Coxsackievirus A21

External ID: CHEMBL2020517

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 8
First Page: 2705
Last Page: 2707
DOI: 10.1016/j.bmcl.2012.02.105

Target ChEMBL ID: CHEMBL613553
ChEMBL Target Name: Coxsackievirus A21
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
30	EC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MT4

External ID: CHEMBL4823995

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Target ChEMBL ID: CHEMBL388
ChEMBL Target Name: MT4
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
200	CC50	>	200000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4823996

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value
LogD	<	0.3
LogD	=	2.4
LogD	=	1.1
LogD	=	3.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepacivirus hominis

External ID: CHEMBL4823993

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Target ChEMBL ID: CHEMBL379
ChEMBL Target Name: Hepatitis C virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
89	EC50	>	89000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Huh-7

External ID: CHEMBL4823994

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Target ChEMBL ID: CHEMBL614039
ChEMBL Target Name: Huh-7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
89	CC50	>	89000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4823999

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	12	%
F	=	57	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4824000

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	89	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4823997

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
permeability	=	0.17	10^-6 cm/s
permeability	=	2.1	10^-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4823998

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Standard Type	Standard Relation	Standard Value	Standard Units
permeability	=	2.1	10^-6 cm/s
permeability	=	1.5	10^-6 cm/s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human orthopneumovirus

External ID: CHEMBL4823991

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Target ChEMBL ID: CHEMBL613127
ChEMBL Target Name: Human orthopneumovirus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.15	EC50	=	150	nM
0.075	EC50	=	75	nM
0.36	EC50	=	360	nM
0.75	EC50	=	750	nM
0.31	EC50	=	310	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEp-2

External ID: CHEMBL4823992

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

Target ChEMBL ID: CHEMBL614735
ChEMBL Target Name: HEp-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.7	CC50	=	8700	nM
34	CC50	=	34000	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4823989

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 8.0
First Page: 5001
Last Page: 5017
DOI: 10.1021/acs.jmedchem.1c00071

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
38	IC50	=	38000	nM

1191237-69-0 靶点实验数据