HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL902332

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 2
First Page: 471
Last Page: 475
DOI: 10.1016/j.bmcl.2006.10.024

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95.9	%
Inhibition	=	82.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL902333

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 2
First Page: 471
Last Page: 475
DOI: 10.1016/j.bmcl.2006.10.024

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.84	IC50	=	5840	nM
4.2	IC50	=	4200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent N-type calcium channel subunit alpha-1B

External ID: CHEMBL902334

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 2
First Page: 471
Last Page: 475
DOI: 10.1016/j.bmcl.2006.10.024

Target ChEMBL ID: CHEMBL4478
ChEMBL Target Name: Voltage-gated N-type calcium channel alpha-1B subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	67.6	%
Inhibition	<	1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2

External ID: CHEMBL766814

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2003
Volume: 13
Issue: 16
First Page: 2773
Last Page: 2775
DOI: 10.1016/s0960-894x(03)00492-x

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3.38844	IC50	=	3388.44	nM
239.883	IC50	=	239883.29	nM	Outside typical range
17.378	IC50	=	17378.01	nM
128.825	IC50	=	128824.96	nM	Outside typical range
128.825	IC50	=	128824.96	nM	Outside typical range
1.51356	IC50	=	1513.56	nM
0.32359	IC50	=	323.59	nM
0.81283	IC50	=	812.83	nM
0.0302	IC50	=	30.2	nM
0.01	IC50	=	10	nM
0.36308	IC50	=	363.08	nM
1.47911	IC50	=	1479.11	nM
1.51356	IC50	=	1513.56	nM
0.15136	IC50	=	151.36	nM
20.893	IC50	=	20892.96	nM
0.01	IC50	=	10	nM
91.2011	IC50	=	91201.08	nM
0.01	IC50	=	10	nM
3.98107	IC50	=	3981.07	nM
50.1187	IC50	=	50118.72	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: SNCA-p-activity-luciferase

Protocol: PROTOCOL TABLE
SEQUENCE No. (e.g., 1, 2, 3, etc.); PARAMETER (e.g., Cells, Incubation, Reagent, etc.); VALUE; DESCRIPTION

1; Cells; 4 uL; Dispense 1500 HEK-293-SNCA-luc cells/well into Greiner 1536-well white / solid bottom tissue culture treated plate. The plate was covered with metal lids with gas-exchange holes.
2; Incubate; 24 hours; Incubate at 37C, 5% CO2, 95% RH.
3; Compounds; 23 nL; Compounds and controls were transferred via a Kalypsys Pin Tool (Wako USA) equipped with a 1536-slotted pin array. The plate was covered with metal lids with gas-exchange holes.
4; Incubate; 24 hours; Incubate at 37C, 5% CO2, 95% RH.
5; Dispense; 1 uL; Dispense Gly-Phe-7-amino-4-trifluoromethylcoumarin (GF-AFC, prepared at 125 uM in PBS) was added. The plate was covered with metal lids with gas-exchange holes.
6; Incubate; 30 min; Incubate at 37C, 5% CO2.
7; Detector; Fluorescence; Measure fluorescence with ViewLux microplate reader (PerkinElmer) equipped with 405/10 excitation and 540/25 emission filters.
8; Dispense; 3 uL; Dispense ONE-Glo (PerkinElmer) lucifase detection reagent was added to each well. Plates were covered with metal lids with gas-exchange holes.
9; Incubate; 15 min; Incubate at room temperature.
10; Detector; Luminescence; Measure luminescence with ViewLux microplate reader (PerkinElmer) equipped with clear filters.

NOTES (numbers refer to sequence above)
1; HEK-293-SNCA-luc were cultured and suspended in phenol-red free DMEM (4.5 g/L glucose, 25 mM HEPES, cat #21063 (Thermo)).
3; Compounds were added to the assay plate in an 11-point intra plate dose response, 1:3 titration in DMSO with a final concentration range of xxx - yyy uM. Vehicle-only plates, with DMSO being pin-transferred to every well, were inserted at the beginning of screening runs to confirm expected assay performance. Activity was normalized to wells containing medium only (-100% activity, full inhibition) and SNCA-luc cells treated with DMSO vehicle control (0% activity), contained on the same plate as test samples.
10; Signals were analyzed, and dose-response curves were fit using the Hill equation. Compounds in curve classes -1.1, -1.2, -2.1, -2.2 in the SNCA-luc assay were considered active. Compounds were eliminated from further consideration if also active (curve class -1.1, -1.2, -1.3, -1.4, -2.1, -2.2, -2.3, -2.4) in the GF-AFC cytotoxicity assay.

Comment: Disclaimer:
Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods.

Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, with a ratio activity curve class of 4, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. For a ratio activity curve class = -1.1, score = 80+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 && abs(ratio.max_response) > 6*10, score = 60+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -2.1 || ( ratio.curve_class==-2.2 && abs(ratio.max_response) > 6*10), score = 40+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 || ratio.curve_class == -2.2, score = 20+abs((log_ac50+4.5)*inf_activity/20). Inconclusive compounds, with a donor curve class other than 4, have PUBCHEM_ACTIVITY_SCORE of 10. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.079 uM	Activity at 1.068 uM	Activity at 11.39 uM	Activity at 57.25 uM	Compound QC
Inactive				-6.75	4.9549	0.9727	0.0901	17.5	4	0 0 0 1	8.9408	15.9527	-1.5916	1.4969	8.9408	QC'd by Sytravon
Inactive				-5.3	4.095	0.9996	5.5	-7.7823	4	0 0 0 1	-11.1081	-7.5736	-7.7353	5.034	-11.1081	QC'd by Sytravon
Inactive				-5.15	4.9549	0.907	-15.9207	9.5	4	0 0 0 1	17.8725	5.2874	13.9021	-13.6839	17.8725	QC'd by Sytravon
Activator	35.4813	46.4095	Single point of activity	-4.45	2.5884	1	45.9404	-0.4691	3	1 0 0 0	35.593	40.1678	-0.3909	1.933	35.593	QC'd by Sytravon
Activator	39.8107	72.2646	Single point of activity	-4.4	4.9549	0.9515	68.1912	-4.0733	3	0 0 0 0	58.0117	5.8738	-9.2278	-8.5224	58.0117	QC'd by Sytravon
Activator	14.1254	45.3319	Partial curve; partial efficacy; poor fit	-4.85	2.4064	0.9982	40.7728	-4.5591	2.4	1 0 0 0	40.0933	-24.9557	-3.8845	11.5254	40.0933	QC'd by Sytravon
Inactive				-5.75	4.9549	0.9291	-20.6086	33.1545	4	1 0 0 0	-12.8464	45.4569	28.2161	-28.42	-12.8464	QC'd by Sytravon
Inactive				-4.35	4.9549	0.855	-24.2184	-0.5	4	0 0 0 0	-18.932	-3.6477	-2.409	4.988	-18.932	QC'd by Sytravon
Inactive				-4.7	3.6272	0.8625	15	-8.5523	4	0 0 0 0	14.477	-2.951	-13.7936	-5.9646	14.477	QC'd by Sytravon
Inactive				-6.7	4.9549	0.6637	3	-16.864	4	0 0 0 0	8.8169	-15.72	6.3794	-6.3599	8.8169	QC'd by Sytravon
Inactive				-4.75	2.4064	0.9999	21.5	-2.4101	4	1 0 0 0	20.2184	33.3778	-2.4251	3.5771	20.2184	QC'd by Sytravon
Inactive				-4.4	4.9549	0.8117	2.5	-8.345	4	0 0 0 0	1.096	-8.966	-5.5054	-11.1209	1.096	QC'd by Sytravon
Activator	39.8107	38.7945	Single point of activity	-4.4	4.9549	0.6241	41.7557	2.9612	3	0 0 0 0	36.2039	21.355	-6.3904	-4.5325	36.2039	QC'd by Sytravon
Inactive				-6.05	4.095	0.9994	-6.0518	20	4	0 0 0 1	20.5156	19.7377	1.4122	-6.2932	20.5156	QC'd by Sytravon
Inactive				-5.2	4.095	1	10.5	-10.1683	4	1 0 0 1	-15.9884	36.1362	-10.1402	8.7939	-15.9884	QC'd by Sytravon
Inactive				-6.5	1.3905	0.9999	-24.241	0.2745	4	0 0 0 1	-5.5981	-4.3546	-20.7587	-23.9509	-5.5981	QC'd by Sytravon
Inactive				-6.8	4.9549	0.711	-2.4459	21	4	0 0 0 0	-3.3453	17.3219	-9.9549	5.5495	-3.3453	QC'd by Sytravon
Activator	39.8107	47.809	Partial curve; partial efficacy; poor fit	-4.4	4.9549	0.5212	50.2399	2.4309	2.4	0 0 0 0	43.4722	30.2363	-10.9855	-11.5143	43.4722	QC'd by Sytravon
Activator	22.3872	75.5081	Partial curve; high efficacy; poor fit	-4.65	1.9673	0.9829	96.5324	21.0243	2.3	0 0 0 0	86.4985	26.0932	16.3365	36.2613	86.4985	QC'd by Sytravon
Inactive				-6.8	4.9549	0.7429	-1	-13.0738	4	0 0 0 0	1.8063	-11.3115	0.8702	-5.1757	1.8063	QC'd by Sytravon

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL902335

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 2
First Page: 471
Last Page: 475
DOI: 10.1016/j.bmcl.2006.10.024

Standard Type	Standard Relation	Standard Value
Ratio	=	1.4
Ratio	>	100

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H

External ID: CHEMBL902331

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 2
First Page: 471
Last Page: 475
DOI: 10.1016/j.bmcl.2006.10.024

Target ChEMBL ID: CHEMBL1859
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1H subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	86	%
Inhibition	=	97	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H

External ID: CHEMBL831595

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 2
First Page: 283
Last Page: 286
DOI: 10.1016/j.bmcl.2004.10.078

Target ChEMBL ID: CHEMBL1859
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1H subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	86	%
Inhibition	=	97	%
Inhibition	=	91.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL831594

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 2
First Page: 283
Last Page: 286
DOI: 10.1016/j.bmcl.2004.10.078

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95.9	%
Inhibition	=	82.5	%
Inhibition	=	88.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL646647

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2000
Volume: 43
Issue: 13
First Page: 2575
Last Page: 2585
DOI: 10.1021/jm0000564

Standard Type	Standard Relation	Standard Value
LogD	=	-0.34
LogD	=	1.8
LogD	=	0.4
LogD	=	2.49
LogD	=	1.47
LogD	=	-2.66
LogD	=	-2.04
LogD	=	-1.24
LogD	=	-0.02
LogD	=	-0.08
LogD	=	0.35
LogD	=	-0.19
LogD	=	-0.02
LogD	=	-0.39
LogD	=	0.11
LogD	=	2.05
LogD	=	1.48
LogD	=	1.47
LogD	=	1.92
LogD	=	-1.34

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent N-type calcium channel subunit alpha-1B

External ID: CHEMBL831593

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 2
First Page: 283
Last Page: 286
DOI: 10.1016/j.bmcl.2004.10.078

Target ChEMBL ID: CHEMBL4478
ChEMBL Target Name: Voltage-gated N-type calcium channel alpha-1B subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	67.6	%
Inhibition	=	30.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL630098

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2003
Volume: 46
Issue: 9
First Page: 1716
Last Page: 1725
DOI: 10.1021/jm021012t

Standard Type	Standard Relation	Standard Value
LogP	=	0.4
LogP	=	0.8
LogP	=	5.8
LogP	=	2.5
LogP	=	5.3
LogP	=	1.3
LogP	=	4.7
LogP	=	5.7
LogP	=	3.3
LogP	=	5.7
LogP	=	5.2
LogP	=	6.2
LogP	=	2.9
LogP	=	4.9
LogP	=	2.8
LogP	=	6.3
LogP	=	5.5
LogP	=	1.3
LogP	=	3.8
LogP	=	5.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：Broad Institute 靶标：N/A

External ID: 7124-01_Inhibitor_SinglePoint_HTS_Activity

Protocol:
Protocol:
1) Plate 10 uL BL2-NFkB-luc cells at 12.5K cells/well, using a Multidrop Combi reagent dispenser (1,250 cells/uL).
2) Add 25 nL compound or positive control, by pin transfer; IKK inhibitor VII will be used at 50 uM.
3) Incubate at 37 masculineC for 1 hour (allowing compounds to enter cells for action).
4) Add 5 uL 192 ng/mL tCD40L per well for a final concentration of 64 ng/ml using a Thermo Multidrop Combi.
5) Incubate at 37 masculineC for 4 hrs, then leave plate at RT for 30 minutes.
6) Add 15 uL SteadyGlo luciferase substrate (Promega) per well using a Thermo Multidrop Combi.
7) Incubate at RT for 5min, then read Luminescence using LJL Analyst HT plate reader.

Comment: PRESENCE OF CONTROLS: Neutral control wells (NC) and positive control wells (PC) were included on every plate.

EXPECTED OUTCOME: Active compounds result in decreasing readout signal.

NORMALIZATION:
The raw signals of the plate wells were normalized using the 'Neutral Controls Minus Inhibitors' method in Genedata Assay Analyzer (v10.0.2):
The median raw signal of the intraplate neutral control wells was set to a normalized activity value of 0.
The median raw signal of the intraplate positive control wells was set to a normalized activity value of -100.
Experimental wells values were scaled to this range.

PATTERN CORRECTION: No plate pattern correction algorithm from Genedata Condoseo (v.10.0.2) was applied.

PUBCHEM_ACTIVITY_SCORE:
This was set as equal to the mean of the normalized sample replicate activities, rounded to the nearest integer .
The minimum PUBCHEM_ACTIVITY_SCORE required for a compound to be called a hit (the activity threshold, or AT) was set at -50.

PERCENTAGE OF ACTIVE REPLICATES:
For each sample, the percentage of replicates (PCT_ACTIVE_REP) which had activity scores >= AT was determined.
The minimum percentage of replicates required for a compound to be called a hit (PAR_T) was set at 55.

PUBCHEM_ACTIVITY_OUTCOME:
Samples passing BOTH threshold criteria were assigned an outcome of 2 (active):
PUBCHEM_ACTIVITY_SCORE >= AT, and PCT_ACTIVE_REP >= PAR_T

Samples passing NEITHER threshold criteria were assigned an outcome of 1 (inactive):
PUBCHEM_ACTIVITY_SCORE < AT, and PCT_ACTIVE_REP < PAR_T

Samples passing AT only were assigned an outcome of 1 (inactive) :
PUBCHEM_ACTIVITY_SCORE >= AT, and PCT_ACTIVE_REP < PAR_T

Samples passing PAR_T only were assigned an outcome of 1 (inactive) :
PUBCHEM_ACTIVITY_SCORE < AT, and PCT_ACTIVE_REP >= PAR_T

REPRODUCIBILITY_COSINE_TRANSFORM	REPLICATE_A_ACTIVITY_SCORE_10uM_(%)	REPLICATE_B_ACTIVITY_SCORE_10uM_(%)
0.7962	-2.349	-0.32
1	5.673	5.654
0.9921	9.247	7.171
1	10.265	10.389
0.9927	-11.538	-9.04
0	4.22
0.9884	1.7	1.248
0.859	20.454	5.179
0.5725	5.367	-0.953
0.98	-5.16	-7.79
0.955	9.686	5.096
0.6821	-13.005	0.453
0.8754	8.354	2.409
0.9468	11.738	5.785
0.9853	-15.255	-10.751
0.526	-1.759	7.464
0.8435	10	2.218
0.9897	19.16	14.325
1	-28.597	-28.833
0.9935	6.701	8.436

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL636394

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2000
Volume: 43
Issue: 13
First Page: 2575
Last Page: 2585
DOI: 10.1021/jm0000564

Standard Type	Standard Relation	Standard Value
delta logD	=	-0.82
delta logD	=	-0.9
delta logD	=	-0.89
delta logD	=	-0.89
delta logD	=	-0.75
delta logD	=	-0.9
delta logD	=	-0.89
delta logD	=	0.9
delta logD	=	-0.9
delta logD	=	-0.38
delta logD	=	-0.9
delta logD	=	0.42
delta logD	=	0.9
delta logD	=	0.65
delta logD	=	0.83
delta logD	=	0.13
delta logD	=	0.04
delta logD	=	0.89
delta logD	=	0.9
delta logD	=	0.87

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2339142

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1887
Last Page: 1890
DOI: 10.1016/j.bmcl.2012.12.072

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	1.69

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H

External ID: CHEMBL903653

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1409
Last Page: 1419
DOI: 10.1016/j.bmc.2006.11.004

Target ChEMBL ID: CHEMBL1859
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1H subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	86	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL903654

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1409
Last Page: 1419
DOI: 10.1016/j.bmc.2006.11.004

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	78.17	%
Inhibition	=	53.99	%
Inhibition	=	30.38	%
Inhibition	=	36.06	%
Inhibition	=	32.5	%
Inhibition	=	37.34	%
Inhibition	=	48.27	%
Inhibition	=	51.81	%
Inhibition	=	40.61	%
Inhibition	=	30.8	%
Inhibition	=	38.53	%
Inhibition	=	38.15	%
Inhibition	=	42.7	%
Inhibition	=	44.22	%
Inhibition	=	44.87	%
Inhibition	=	33.18	%
Inhibition	=	30.29	%
Inhibition	=	29.68	%
Inhibition	=	28.36	%
Inhibition	=	26.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL903655

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1409
Last Page: 1419
DOI: 10.1016/j.bmc.2006.11.004

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95.9	%
Inhibition	=	93.17	%
Inhibition	=	75.1	%
Inhibition	=	79.2	%
Inhibition	=	76.1	%
Inhibition	=	60.5	%
Inhibition	=	94.6	%
Inhibition	=	84.3	%
Inhibition	=	84.1	%
Inhibition	=	78	%
Inhibition	=	76.2	%
Inhibition	=	95.4	%
Inhibition	=	79.1	%
Inhibition	=	80.3	%
Inhibition	=	79.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL2339145

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1887
Last Page: 1890
DOI: 10.1016/j.bmcl.2012.12.072

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.76	IC50	=	760	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL2339144

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1887
Last Page: 1890
DOI: 10.1016/j.bmcl.2012.12.072

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	81	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2

External ID: CHEMBL2339143

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1887
Last Page: 1890
DOI: 10.1016/j.bmcl.2012.12.072

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
13.97	IC50	=	13970	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL1839503

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 19
First Page: 5910
Last Page: 5915
DOI: 10.1016/j.bmcl.2011.07.087

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	78.95	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL903656

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 3
First Page: 1409
Last Page: 1419
DOI: 10.1016/j.bmc.2006.11.004

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.47	IC50	=	4470	nM
3.63	IC50	=	3630	nM
6.01	IC50	=	6010	nM
2.64	IC50	=	2640	nM
2.61	IC50	=	2610	nM
2.78	IC50	=	2780	nM
3.52	IC50	=	3520	nM
1.8	IC50	=	1800	nM
0.37	IC50	=	370	nM
3.27	IC50	=	3270	nM
3.81	IC50	=	3810	nM
3.14	IC50	=	3140	nM
1.48	IC50	=	1480	nM
0.28	IC50	=	280	nM
0.75	IC50	=	750	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4303819

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value
Inhibition index	=	0.1602
Inhibition index	=	0.05118
Inhibition index	=	0.4224
Inhibition index	=	0.0165
Inhibition index	=	0.2502
Inhibition index	=	0.07412
Inhibition index	=	0.07718
Inhibition index	=	-0.01621
Inhibition index	=	0.222
Inhibition index	=	0.4759
Inhibition index	=	0.2023
Inhibition index	=	0.02609
Inhibition index	=	0.646
Inhibition index	=	0.2499
Inhibition index	=	2.099
Inhibition index	=	0.3518
Inhibition index	=	0.04502
Inhibition index	=	0.1687
Inhibition index	=	0.0604
Inhibition index	=	0.09117

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2

External ID: CHEMBL1839504

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 19
First Page: 5910
Last Page: 5915
DOI: 10.1016/j.bmcl.2011.07.087

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.92	IC50	=	920	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL4430306

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 21
First Page: 5028
Last Page: 5035
DOI: 10.1016/j.bmc.2016.06.006

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	79.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H

External ID: CHEMBL4430307

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 21
First Page: 5028
Last Page: 5035
DOI: 10.1016/j.bmc.2016.06.006

Target ChEMBL ID: CHEMBL1859
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1H subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	76	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 3A4

External ID: CHEMBL2185188

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 4896
Last Page: 4933
DOI: 10.1021/jm300065h

Target ChEMBL ID: CHEMBL340
ChEMBL Target Name: Cytochrome P450 3A4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	Kinact	=	0.094	/min
2.3	Ki	=	2300	nM
	Kinact	=	0.4	/min
	Kinact	=	0.08	/min
23	Ki	=	23000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：N/A

External ID: SCA2002

Protocol: HEK293 cultured cells will be dosed with titrated compounds and incubated for 72 hr at 37 degrees C. Toxicity will be assessed using the CellTiter Glo kit (Promega), which uses intracellular ATP concentration as a viability marker.

Comment: Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.091 uM	Activity at 0.457 uM	Activity at 2.290 uM	Activity at 11.40 uM	Activity at 57.10 uM	Compound QC
Cytotoxic	35.4813	61.0337	Single point of activity	-4.45	2.4729	0.9637	-64.3328	-3.2991	-3	0 0 0 0 0	-49.8733	3.1174	-5.94	-7.2573	-6.425	-49.8733	QC'd by "SigmaAldrich"
Cytotoxic	17.7828	67.679	Single point of activity	-4.75	3.0654	0.9561	-46.7507	20.9283	-3	0 0 0 0 0	-44.971	22.4039	11.1684	27.8842	7.6544	-44.971	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-12.6837	16.8271	7.7283	13.5091	6.8161	-12.6837	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-17.8401	10.8057	-6.4777	0.5573	5.2328	-17.8401	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-15.1256	6.2512	-4.3289	-0.9994	2.3229	-15.1256	QC'd by "SigmaAldrich"
Inactive									4		-7.475	-6.7939	-8.3449	-5.3761	-5.806	-7.475	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	9.1001	25.677	10.5612	34.0633	37.5801	9.1001	QC'd by "SigmaAldrich"
Cytotoxic	19.9526	117.3314	Partial curve; high efficacy; poor fit	-4.7	0.9	0.9005	-127.2239	-9.8926	-2.3	0 0 0 0 0	-100.9714	3.1608	-27.6796	-30.9309	-43.8285	-100.9714	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-4.1328	-1.1519	6.0784	-3.0376	0.8686	-4.1328	QC'd by "SigmaAldrich"
Cytotoxic	39.8107	28.7208	Partial curve; partial efficacy; poor fit	-4.4	3.6772	0.9911	-35.9992	-7.2784	-2.4	0 0 0 0 0	-29.9993	-5.6487	-7.8259	-8.1414	-7.5339	-29.9993	QC'd by "SigmaAldrich"
Cytotoxic	31.6228	97.2268	Single point of activity	-4.5	2.0437	0.973	-92.4117	4.8151	-3	0 0 0 0 0	-70.0089	13.6895	2.0458	-1.2716	-5.7764	-70.0089	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-15.2145	-2.8973	-8.6565	-5.5649	-6.8877	-15.2145	QC'd by "SigmaAldrich"
Cytotoxic	28.1838	72.8012	Single point of activity	-4.55	1.8579	0.9604	-62.5145	10.2867	-3	0 0 0 0 0	-47.4509	18.2829	5.32	6.0934	0.2154	-47.4509	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-27.5276	-7.835	-4.5068	-11.5619	-3.8922	-27.5276	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	0.7905	18.0284	4.1591	10.4155	14.9325	0.7905	QC'd by "SigmaAldrich"
Inactive									4	1 0 0 0 0	-17.8147	24.7332	1.5663	-0.1577	4.9397	-17.8147	QC'd by "SigmaAldrich"
Cytotoxic	15.8489	53.823	Partial curve; partial efficacy	-4.8	1.111	0.9948	-66.8063	-12.9833	-2.2	0 0 0 0 0	-56.0886	-14.5996	-11.8947	-19.2332	-35.0535	-56.0886	QC'd by "SigmaAldrich"
Cytotoxic	7.0795	99.3408	Single point of activity	-5.15	4.9549	0.992	-101.8303	-2.4895	-3	0 0 0 0 1	-39.6531	0.3061	-8.0065	0.6081	-94.2874	-39.6531	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-20.8827	-12.5354	-16.3567	-16.6681	-12.1166	-20.8827	QC'd by "SigmaAldrich"
Cytotoxic	22.3872	99.0917	Partial curve; high efficacy	-4.65	2.7202	0.9947	-97.0716	2.0201	-2.1	0 0 0 0 0	-89.3845	5.4144	-2.4263	3.2332	-11.8203	-89.3845	QC'd by "SigmaAldrich"

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1614670

Protocol: N/A

Comment: Journal: Drug Metab Dispos
Year: 2008
Volume: 36
Issue: 7
First Page: 1385
Last Page: 1405
DOI: 10.1124/dmd.108.020479

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	0.73	L.kg-1
Vdss	=	2.6	L.kg-1
Vdss	=	1.6	L.kg-1
Vdss	=	0.096	L.kg-1
Vdss	=	0.32	L.kg-1
Vdss	=	1.6	L.kg-1
Vdss	=	2.1	L.kg-1
Vdss	=	6.1	L.kg-1
Vdss	=	1.9	L.kg-1
Vdss	=	12	L.kg-1
Vdss	=	0.8	L.kg-1
Vdss	=	1	L.kg-1
Vdss	=	3.1	L.kg-1
Vdss	=	3.2	L.kg-1
Vdss	=	1.2	L.kg-1
Vdss	=	13	L.kg-1
Vdss	=	45	L.kg-1
Vdss	=	0.37	L.kg-1
Vdss	=	1.5	L.kg-1
Vdss	=	4.1	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1614671

Protocol: N/A

Comment: Journal: Drug Metab Dispos
Year: 2008
Volume: 36
Issue: 7
First Page: 1385
Last Page: 1405
DOI: 10.1124/dmd.108.020479

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	4.7	mL.min-1.kg-1
CL	=	18	mL.min-1.kg-1
CL	=	2.5	mL.min-1.kg-1
CL	=	1.3	mL.min-1.kg-1
CL	=	5.1	mL.min-1.kg-1
CL	=	2.4	mL.min-1.kg-1
CL	=	8.3	mL.min-1.kg-1
CL	=	9.7	mL.min-1.kg-1
CL	=	31	mL.min-1.kg-1
CL	=	13	mL.min-1.kg-1
CL	=	16	mL.min-1.kg-1
CL	=	0.38	mL.min-1.kg-1
CL	=	13	mL.min-1.kg-1
CL	=	15	mL.min-1.kg-1
CL	=	0.7	mL.min-1.kg-1
CL	=	8.2	mL.min-1.kg-1
CL	=	20	mL.min-1.kg-1
CL	=	0.65	mL.min-1.kg-1
CL	=	2.1	mL.min-1.kg-1
CL	=	13	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1614672

Protocol: N/A

Comment: Journal: Drug Metab Dispos
Year: 2008
Volume: 36
Issue: 7
First Page: 1385
Last Page: 1405
DOI: 10.1124/dmd.108.020479

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Fu	=	0.06
Fu	=	0.95
Fu	=	0.75
Fu	=	0.01
Fu	=	0.62
Fu	=	0.73
Fu	=	0.7
Fu	=	0.8
Fu	=	0.72
Fu	=	0.075
Fu	=	0.58
Fu	=	0.023
Fu	=	0.88
Fu	=	0.18
Fu	=	0.01
Fu	=	0.029
Fu	=	0.25
Fu	=	0.04
Fu	=	0.5
Fu	=	0.18

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1614673

Protocol: N/A

Comment: Journal: Drug Metab Dispos
Year: 2008
Volume: 36
Issue: 7
First Page: 1385
Last Page: 1405
DOI: 10.1124/dmd.108.020479

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	2.6	hr
MRT	=	2.4	hr
MRT	=	11	hr
MRT	=	1.2	hr
MRT	=	1	hr
MRT	=	11	hr
MRT	=	4.2	hr
MRT	=	10	hr
MRT	=	1	hr
MRT	=	15	hr
MRT	=	1	hr
MRT	=	44	hr
MRT	=	4	hr
MRT	=	3.6	hr
MRT	=	27	hr
MRT	=	26	hr
MRT	=	38	hr
MRT	=	9.5	hr
MRT	=	12	hr
MRT	=	5.3	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1614674

Protocol: N/A

Comment: Journal: Drug Metab Dispos
Year: 2008
Volume: 36
Issue: 7
First Page: 1385
Last Page: 1405
DOI: 10.1124/dmd.108.020479

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	2	hr
T1/2	=	2	hr
T1/2	=	8.9	hr
T1/2	=	1.4	hr
T1/2	=	1.1	hr
T1/2	=	8.6	hr
T1/2	=	3.8	hr
T1/2	=	7.3	hr
T1/2	=	1.69	hr
T1/2	=	16	hr
T1/2	=	0.78	hr
T1/2	=	42	hr
T1/2	=	3.6	hr
T1/2	=	2.5	hr
T1/2	=	26	hr
T1/2	=	26	hr
T1/2	=	36	hr
T1/2	=	13	hr
T1/2	=	9.6	hr
T1/2	=	5.6	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H

External ID: CHEMBL4393242

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 10
First Page: 1168
Last Page: 1172
DOI: 10.1016/j.bmcl.2019.03.026

Target ChEMBL ID: CHEMBL1859
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1H subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	76	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4393243

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 10
First Page: 1168
Last Page: 1172
DOI: 10.1016/j.bmcl.2019.03.026

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Stability				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2

External ID: CHEMBL4393244

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 10
First Page: 1168
Last Page: 1172
DOI: 10.1016/j.bmcl.2019.03.026

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Replicase polyprotein 1ab

External ID: CHEMBL4495582

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13.77	%
Inhibition	=	2.35	%
Inhibition	=	21.17	%
Inhibition	=	18.36	%
Inhibition	=	5.381	%
Inhibition	=	18.17	%
Inhibition	=	10.15	%
Inhibition	=	29.56	%
Inhibition	=	18.27	%
Inhibition	=	11.42	%
Inhibition	=	15.4	%
Inhibition	=	7.437	%
Inhibition	=	-3.216	%
Inhibition	=	18	%
Inhibition	=	1.021	%
Inhibition	=	16.4	%
Inhibition	=	2.544	%
Inhibition	=	19.11	%
Inhibition	=	26.15	%
Inhibition	=	5.133	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: SCA2001

Protocol: 4 ul of HEK293-ATXN2-FFLuc cell suspension (TBD cells/microL in phenol-red free DMEM) are dispensed into Greiner white solid bottom 1536-well assay plates, yielding a final well density of TBD cells/well. Plates are incubated for 2 hrs at 37 degrees C in 5% humidified CO2 to allow cell attachment. Compounds are then transferred via Kalypsys pin tool equipped with 1536-pin array (10nl slotted pins, V&P Scientific, San Diego, CA). In addition, duplicate serial dilutions of the control compounds ChemBridge 5553825, a previously identified ATXN2 expression inhibitor, and a known luciferase inhibitor, are pin-transferred. After incubation at 37 degrees C in 5% humidified CO2 for 24 hrs, CellTiter-Fluor reagent (1 ul) (Promega, Madison, WI) is then added and plates are incubated for 30 minutes, before being transferred to a ViewLux high-throughput CCD imager (PerkinElmer), wherein single end-point fluorescence measurements are acquired using the 405 nm excitation/525 nm emission filter set to assess cell viability. Next, Bright-Glo luciferase substrate detection reagent (3 ul) (Promega, Madison, WI) is added to each well and incubated for an additional 5 minutes. Luminescence is then measured on the ViewLux imager equipped with a clear emission filter using a 2 sec exposure.

Comment: Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.091 uM	Activity at 0.457 uM	Activity at 2.290 uM	Activity at 11.40 uM	Activity at 57.10 uM	Compound QC
Inhibitor	25.1189	32.3251	Single point of activity	-4.6	2.2526	0.9519	-37.3265	-5.0013	-3	0 0 0 0 0	-32.7721	-2.0845	-9.4243	-4.1966	-9.8488	-32.7721	QC'd by "SigmaAldrich"
Inhibitor	15.8489	86.1551	Partial curve; partial efficacy	-4.8	2.2526	0.9831	-76.8113	9.3438	-2.2	0 0 0 0 0	-70.6903	12.0835	1.9513	12.4338	-17.7233	-70.6903	QC'd by "SigmaAldrich"
Inhibitor	17.7828	48.1305	Partial curve; partial efficacy	-4.75	2.4064	0.9751	-31.5989	16.5316	-2.2	0 0 0 0 0	-28.8193	14.9752	13.3176	21.3387	3.9358	-28.8193	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-6.6363	18.2144	-12.0466	1.106	0.4089	-6.6363	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-12.5356	4.3784	-6.3143	-0.9752	2.5146	-12.5356	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	1.099	-8.996	0.2771	-1.7165	-4.9277	1.099	QC'd by "SigmaAldrich"
Inactive									4		-2.5324	11.7092	-5.338	16.9841	4.1492	-2.5324	QC'd by "SigmaAldrich"
Inhibitor	0.1	62.2751	Complete curve; high efficacy; poor fit	-7	3.6272	0.6023	-80.9362	-18.6611	-1.3	0 0 0 0 0	-96.3526	-44.7427	-80.7506	-86.7134	-60.3161	-96.3526	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	11.1048	-0.9478	10.1842	-2.642	-2.3029	11.1048	QC'd by "SigmaAldrich"
Inhibitor	25.1189	38.4189	Single point of activity	-4.6	3.0654	0.9347	-37.0363	1.3826	-3	0 0 0 0 0	-34.0012	-1.7871	-1.6511	8.347	-1.9146	-34.0012	QC'd by "SigmaAldrich"
Inhibitor	28.1838	81.8981	Single point of activity	-4.55	3.0654	0.9956	-86.0465	-4.1484	-3	0 0 0 0 0	-77.6867	-1.7089	-7.5724	-3.1708	-9.097	-77.6867	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-25.5241	-2.3053	-3.3901	18.5124	-3.8247	-25.5241	QC'd by "SigmaAldrich"
Inhibitor	14.1254	63.2086	Partial curve; partial efficacy	-4.85	2.4064	0.997	-57.2086	6	-2.2	0 0 0 0 0	-56.0868	6.9914	3.6249	5.298	-16.6421	-56.0868	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-6.4413	-5.1065	2.3605	3.099	2.5399	-6.4413	QC'd by "SigmaAldrich"
Inactive									4		7.6671	12.951	0.9859	7.263	13.989	7.6671	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 1	14.805	15.872	-3.6668	19.3074	22.4188	14.805	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	7.2744	-8.4147	-8.0803	-9.3101	-8.653	7.2744	QC'd by "SigmaAldrich"
Inhibitor	4.4668	81.1301	Complete curve; high efficacy; poor fit	-5.35	4.9549	0.9504	-82.3177	-1.1877	-1.3	0 0 0 0 0	-68.2561	-0.1456	-3.7369	-2.3223	-95.2752	-68.2561	QC'd by "SigmaAldrich"
Inactive									4	0 0 0 0 0	-14.833	-9.0881	-9.8183	-8.0979	-11.1419	-14.833	QC'd by "SigmaAldrich"
Inhibitor	15.8489	106.7713	Partial curve; high efficacy	-4.8	2.2526	0.9896	-102.0021	4.7692	-2.1	0 0 0 0 0	-96.0471	9.9358	-2.0726	5.7106	-31.0661	-96.0471	QC'd by "SigmaAldrich"

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL4393241

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 10
First Page: 1168
Last Page: 1172
DOI: 10.1016/j.bmcl.2019.03.026

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	81	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL1175152

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 14
First Page: 4219
Last Page: 4222
DOI: 10.1016/j.bmcl.2010.05.030

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1.94	IC50	=	1940	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL1175150

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 14
First Page: 4219
Last Page: 4222
DOI: 10.1016/j.bmcl.2010.05.030

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL1121058

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 9
First Page: 2705
Last Page: 2708
DOI: 10.1016/j.bmcl.2010.03.084

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.17	IC50	=	3170	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633100

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2000
Volume: 43
Issue: 13
First Page: 2575
Last Page: 2585
DOI: 10.1021/jm0000564

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL1121057

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 9
First Page: 2705
Last Page: 2708
DOI: 10.1016/j.bmcl.2010.03.084

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	78.92	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sphingomyelin phosphodiesterase

External ID: CHEMBL943086

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 2
First Page: 219
Last Page: 237
DOI: 10.1021/jm070524a

Target ChEMBL ID: CHEMBL2760
ChEMBL Target Name: Sphingomyelin phosphodiesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	92.1	%
Activity	=	112.1	%
Activity	=	86.1	%
Activity	=	34.8	%
Activity	=	42.4	%
Activity	=	123.9	%
Activity	=	118.8	%
Activity	=	108.3	%
Activity	=	22.2	%
Activity	=	33.6	%
Activity	=	21.8	%
Activity	=	118.2	%
Activity	=	11.7	%
Activity	=	12.7	%
Activity	=	26.2	%
Activity	=	109.1	%
Activity	=	79.1	%
Activity	=	95.1	%
Activity	=	117.9	%
Activity	=	49.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2

External ID: CHEMBL889313

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 13
First Page: 2931
Last Page: 2941
DOI: 10.1021/jm0700565

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: HERG
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	0.77
Ratio Ki	=	0.91
Ratio Ki	=	4.4
Ratio Ki	=	1.85
Ratio Ki	=	1.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1H

External ID: CHEMBL909720

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 19
First Page: 5244
Last Page: 5248
DOI: 10.1016/j.bmcl.2006.05.031

Target ChEMBL ID: CHEMBL1859
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1H subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	86	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL909721

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 19
First Page: 5244
Last Page: 5248
DOI: 10.1016/j.bmcl.2006.05.031

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	89.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent T-type calcium channel subunit alpha-1G

External ID: CHEMBL910266

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 19
First Page: 5244
Last Page: 5248
DOI: 10.1016/j.bmcl.2006.05.031

Target ChEMBL ID: CHEMBL4641
ChEMBL Target Name: Voltage-gated T-type calcium channel alpha-1G subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.48	IC50	=	1480	nM

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	2.6	hr
MRT	=	2.4	hr
MRT	=	11	hr
MRT	=	1.2	hr
MRT	=	1	hr
MRT	=	11	hr
MRT	=	4.2	hr
MRT	=	10	hr
MRT	=	1	hr
MRT	=	15	hr
MRT	=	1	hr
MRT	=	44	hr
MRT	=	4	hr
MRT	=	3.6	hr
MRT	=	27	hr
MRT	=	26	hr
MRT	=	38	hr
MRT	=	9.5	hr
MRT	=	12	hr
MRT	=	5.3	hr

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	2.6	hr
MRT	=	2.4	hr
MRT	=	11	hr
MRT	=	1.2	hr
MRT	=	1	hr
MRT	=	11	hr
MRT	=	4.2	hr
MRT	=	10	hr
MRT	=	1	hr
MRT	=	15	hr
MRT	=	1	hr
MRT	=	44	hr
MRT	=	4	hr
MRT	=	3.6	hr
MRT	=	27	hr
MRT	=	26	hr
MRT	=	38	hr
MRT	=	9.5	hr
MRT	=	12	hr
MRT	=	5.3	hr

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%

116644-53-2 靶点实验数据

Standard Type	Standard Relation	Standard Value	Standard Units
MRT	=	2.6	hr
MRT	=	2.4	hr
MRT	=	11	hr
MRT	=	1.2	hr
MRT	=	1	hr
MRT	=	11	hr
MRT	=	4.2	hr
MRT	=	10	hr
MRT	=	1	hr
MRT	=	15	hr
MRT	=	1	hr
MRT	=	44	hr
MRT	=	4	hr
MRT	=	3.6	hr
MRT	=	27	hr
MRT	=	26	hr
MRT	=	38	hr
MRT	=	9.5	hr
MRT	=	12	hr
MRT	=	5.3	hr

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%
F	=	79	%