HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL871721

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Standard Type	Standard Relation	Standard Value	Standard Units
E	=	-270	mV
E	=	-292	mV
E	=	-346	mV
E	=	-225	mV
E	=	-277	mV
E	=	-164	mV
E	=	-314	mV
E	=	-280	mV

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL637979

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	7.3	hr
T1/2	=	14	hr
T1/2	=	4.3	hr
T1/2	=	0.91	hr
T1/2	=	4.8	hr
T1/2	=	18	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL847159

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Standard Type	Standard Relation	Standard Value	Standard Units
E	=	-303	mV
E	=	-321	mV
E	=	-361	mV
E	=	-325	mV
E	=	-354	mV
E	=	-244	mV
E	=	-334	mV
E	=	-314	mV

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632268

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Standard Type	Standard Relation	Standard Value
pKa	=	6.21
pKa	=	6.29
pKa	=	6.61
pKa	=	5
pKa	=	5.41
pKa	=	6.47
pKa	=	6.53
pKa	=	6.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL637981

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	0.84	hr
T1/2	=	0.99	hr
T1/2	=	5.2	hr
T1/2	=	0.68	hr
T1/2	=	0.77	hr
T1/2	=	3.9	hr
T1/2	=	2.3	hr
T1/2	=	8.4	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL845955

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value
Ratio	=	14.9
Ratio	=	9
Ratio	=	7.8
Ratio	=	13
Ratio	=	21
Ratio	=	1.5
Ratio	=	2.1
Ratio	=	4.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL653926

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	9.9
Ratio	=	10
Ratio	=	16
Ratio	=	13.6
Ratio	=	5.3
Ratio	=	0.32
Ratio	=	16
Ratio	=	6
Ratio	=	11.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL626445

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Standard Type	Standard Relation	Standard Value
Rm	=	-0.85
Rm	=	-0.76
Rm	=	-0.88
Rm	=	-0.25
Rm	=	-0.46
Rm	=	-0.63
Rm	=	-0.74
Rm	=	-0.29

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL811263

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Standard Type	Standard Relation	Standard Value
CT10	=	0.47
CT10	=	2
CT10	=	22
CT10	=	0.68
CT10	=	2
CT10	=	8
CT10	=	720
CT10	=	540
CT10	=	575

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL624081

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Standard Type	Standard Relation	Standard Value	Standard Units
K	=	18	M-1
K	=	8.8	M-1
K	=	1.9	M-1
K	=	7	M-1
K	=	2.4	M-1
K	=	175	M-1
K	=	5.3	M-1
K	=	11.7	M-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL640106

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value
A0	=	0.98
A0	=	1.12
A0	=	0.78
A0	=	0.56
A0	=	0.84
A0	=	0.45
A0	=	0.68
A0	=	1.03

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL640107

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value
A0	=	0.86
A0	=	0.65
A0	=	0.76
A0	=	0.79
A0	=	0.64
A0	=	0.78
A0	=	1.11

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UV4

External ID: CHEMBL813693

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Target ChEMBL ID: CHEMBL612800
ChEMBL Target Name: UV4
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.2E-4	IC50	=	0.62	nM
0.002	IC50	=	2	nM
0.59	IC50	=	590	nM
0.41	IC50	=	410	nM
3.45	IC50	=	3450	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：UV4

External ID: CHEMBL813692

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Target ChEMBL ID: CHEMBL612800
ChEMBL Target Name: UV4
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0033	IC50	=	3.3	nM
0.012	IC50	=	12	nM
1.95	IC50	=	1950	nM
6.2	IC50	=	6200	nM
19.4	IC50	=	19400	nM
11.6	IC50	=	11600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO-AA8

External ID: CHEMBL658555

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Target ChEMBL ID: CHEMBL614555
ChEMBL Target Name: CHO-AA8
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.033	IC50	=	33	nM
0.25	IC50	=	250	nM
2.9	IC50	=	2900	nM
18.9	IC50	=	18900	nM
62	IC50	=	62000	nM
43	IC50	=	43000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL852202

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value
Ratio	=	3.8
Ratio	=	4.6
Ratio	=	4.2
Ratio	=	4.9
Ratio	=	1.4
Ratio	=	1.2
Ratio	=	2.3
Ratio	=	4.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL881847

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

Standard Type	Standard Relation	Standard Value
Ratio	=	35.54
Ratio	=	5
Ratio	=	5.3
Ratio	=	3.7
Ratio	=	1.3
Ratio	=	1.2
Ratio	=	3.3
Ratio	=	4.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL641597

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 31
Last Page: 38
DOI: 10.1021/jm00121a007

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	CO	=	0.04	mM
100	CO	=	0.1	mM
10	CO	=	10	uM
30000	CO	=	30	mM
50000	CO	=	50	mM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nucleic Acid

External ID: CHEMBL665229

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 1
First Page: 23
Last Page: 30
DOI: 10.1021/jm00121a006

Target ChEMBL ID: CHEMBL345
ChEMBL Target Name: Nucleic Acid
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Log K	=	6.92	M-1
Log K	=	7.23	M-1
Log K	=	6.76	M-1
Log K	=	5.95	M-1
Log K	=	6.15	M-1
Log K	=	6.06	M-1
Log K	=	7.11	M-1
Log K	=	6.5	M-1

116374-65-3 靶点实验数据