HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N-acylethanolamine-hydrolyzing acid amidase

External ID: CHEMBL2066781

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 10
First Page: 4824
Last Page: 4836
DOI: 10.1021/jm300349j

Target ChEMBL ID: CHEMBL2034805
ChEMBL Target Name: N-acylethanolamine-hydrolyzing acid amidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.5	IC50	=	500	nM
15	IC50	=	15000	nM
0.22	IC50	=	220	nM
0.19	IC50	=	190	nM
0.7	IC50	=	700	nM
100	IC50	>	100000	nM
0.13	IC50	=	130	nM
49.2	IC50	=	49200	nM
10	IC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：General amino-acid permease GAP1

External ID: CHEMBL1228071

Protocol: N/A

Comment: Journal: Nat. Chem. Biol.
Year: 2009
Volume: 5
Issue: 1
First Page: 45
Last Page: 52
DOI: 10.1038/nchembio.132

Target ChEMBL ID: CHEMBL3308953
ChEMBL Target Name: General amino-acid permease GAP1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	>=	30	%
Inhibition	<	15	%
Inhibition	>=	30	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	>=	30	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	>=	30	%
Inhibition	<	15	%
Inhibition	<	15	%
Inhibition	=	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_7913_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50	>	100	>	100000	Q5KTC7	BDBM50389010	N-acylethanolamine-hydrolyzing acid amidase
IC50	>	100	>	100000	Q5KTC7	BDBM50389011	N-acylethanolamine-hydrolyzing acid amidase
IC50	>	100	>	100000	Q5KTC7	BDBM50389012	N-acylethanolamine-hydrolyzing acid amidase
IC50		15		15000	Q5KTC7	BDBM50389015	N-acylethanolamine-hydrolyzing acid amidase
IC50		0.42		420	Q5KTC7	BDBM50416509	N-acylethanolamine-hydrolyzing acid amidase
IC50	>	100	>	100000	Q5KTC7	BDBM223536	N-acylethanolamine-hydrolyzing acid amidase
IC50	>	100	>	100000	Q5KTC7	BDBM223538	N-acylethanolamine-hydrolyzing acid amidase
IC50	>	100	>	100000	Q5KTC7	BDBM223539	N-acylethanolamine-hydrolyzing acid amidase
IC50	>	100	>	100000	Q5KTC7	BDBM223540	N-acylethanolamine-hydrolyzing acid amidase

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5576385

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2024
Volume: 106
First Page: 129731
Last Page: 129731
DOI: 10.1016/j.bmcl.2024.129731

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.5	IC50	=	5500	nM
4.6	IC50	=	4600	nM
5.5	IC50	=	5500	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1

External ID: CHEMBL5576386

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2024
Volume: 106
First Page: 129731
Last Page: 129731
DOI: 10.1016/j.bmcl.2024.129731

Target ChEMBL ID: CHEMBL4685
ChEMBL Target Name: Indoleamine 2,3-dioxygenase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-5.5	%
Inhibition	=	100	%
Inhibition	=	100	%
Inhibition	=	10	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SK-OV-3

External ID: CHEMBL5576387

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2024
Volume: 106
First Page: 129731
Last Page: 129731
DOI: 10.1016/j.bmcl.2024.129731

Target ChEMBL ID: CHEMBL614925
ChEMBL Target Name: SK-OV-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

1145-80-8 靶点实验数据