HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_3190_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.5	500	P27338	BDBM29152	Amine oxidase [flavin-containing] B
IC50	25.36	25360	P27338	BDBM29153	Amine oxidase [flavin-containing] B
IC50	7.68	7680	P27338	BDBM29156	Amine oxidase [flavin-containing] B
IC50	0.91	910	P27338	BDBM29157	Amine oxidase [flavin-containing] B
IC50	0.6	600	P27338	BDBM29158	Amine oxidase [flavin-containing] B
IC50	0.64	640	P27338	BDBM29159	Amine oxidase [flavin-containing] B
IC50	0.25	250	P27338	BDBM29160	Amine oxidase [flavin-containing] B
IC50	0.25	250	P27338	BDBM29161	Amine oxidase [flavin-containing] B
IC50	19.45	19450	P21397	BDBM29162	Amine oxidase [flavin-containing] A
IC50	0.71	710	P27338	BDBM29162	Amine oxidase [flavin-containing] B
IC50	15.67	15670	P21397	BDBM29163	Amine oxidase [flavin-containing] A
IC50	0.89	890	P27338	BDBM29163	Amine oxidase [flavin-containing] B
IC50	15.98	15980	P21397	BDBM29165	Amine oxidase [flavin-containing] A
IC50	0.82	820	P27338	BDBM29166	Amine oxidase [flavin-containing] B
IC50	14.76	14760	P21397	BDBM29167	Amine oxidase [flavin-containing] A
IC50	2.84	2840	P27338	BDBM29167	Amine oxidase [flavin-containing] B
IC50	13.06	13060	P21397	BDBM29168	Amine oxidase [flavin-containing] A
IC50	0.067	67	P27338	BDBM29168	Amine oxidase [flavin-containing] B
IC50	9.97	9970	P21397	BDBM29169	Amine oxidase [flavin-containing] A
IC50	1.14	1140	P27338	BDBM29169	Amine oxidase [flavin-containing] B

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL964046

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1935
Last Page: 1942
DOI: 10.1021/jm801496u

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	6.5E-5
Ratio IC50	=	3362
Ratio IC50	<	0.36
Ratio IC50	=	17
Ratio IC50	>	3.9
Ratio IC50	>	31
Ratio IC50	>	110
Ratio IC50	=	24
Ratio IC50	>	156
Ratio IC50	>	400
Ratio IC50	>	400
Ratio IC50	=	27
Ratio IC50	=	23
Ratio IC50	<	0.16
Ratio IC50	>	122
Ratio IC50	=	5.2
Ratio IC50	=	195
Ratio IC50	=	6664
Ratio IC50	=	0.71
Ratio IC50	=	0.89

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A

External ID: CHEMBL964041

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1935
Last Page: 1942
DOI: 10.1021/jm801496u

Target ChEMBL ID: CHEMBL1951
ChEMBL Target Name: Monoamine oxidase A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.56	IC50	=	6560	nM
13.12	IC50	=	13120	nM
59.56	IC50	=	59560	nM
52.62	IC50	=	52620	nM
15.14	IC50	=	15140	nM
15.98	IC50	=	15980	nM
13.06	IC50	=	13060	nM
9.97	IC50	=	9970	nM
9.67	IC50	=	9670	nM
9.33	IC50	=	9330	nM
20.63	IC50	=	20630	nM
9.79	IC50	=	9790	nM
12.76	IC50	=	12760	nM
18.77	IC50	=	18770	nM
9.45	IC50	=	9450	nM
61.46	IC50	=	61460	nM
16.04	IC50	=	16040	nM
11.43	IC50	=	11430	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B

External ID: CHEMBL964042

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1935
Last Page: 1942
DOI: 10.1021/jm801496u

Target ChEMBL ID: CHEMBL2039
ChEMBL Target Name: Monoamine oxidase B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.76	IC50	=	760	nM
41.64	IC50	=	41640	nM
21.56	IC50	=	21560	nM
0.91	IC50	=	910	nM
0.6	IC50	=	600	nM
0.25	IC50	=	250	nM
0.25	IC50	=	250	nM
0.71	IC50	=	710	nM
0.89	IC50	=	890	nM
0.65	IC50	=	650	nM
0.82	IC50	=	820	nM
0.067	IC50	=	67	nM
1.14	IC50	=	1140	nM
0.0014	IC50	=	1.4	nM
0.8	IC50	=	800	nM
22.45	IC50	=	22450	nM
1.29	IC50	=	1290	nM
9.23	IC50	=	9230	nM
0.38	IC50	=	380	nM
0.86	IC50	=	860	nM

1136858-52-0 靶点实验数据