HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3993358

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 3
First Page: 1076
Last Page: 1088
DOI: 10.1021/acs.jmedchem.6b01285

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity				Not Determined
Activity	=	30.5	%
Activity	=	21.8	%
Activity				Not Determined
Activity				Not Determined
Activity	=	59.4	%
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity	=	36.6	%
Activity	=	119.5	%
Activity	=	67.5	%
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity	=	45.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3993357

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 3
First Page: 1076
Last Page: 1088
DOI: 10.1021/acs.jmedchem.6b01285

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity				Not Determined
Activity	=	34.8	%
Activity	=	34.6	%
Activity				Not Determined
Activity				Not Determined
Activity	=	21.4	%
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity	=	77.4	%
Activity	=	56.4	%
Activity	=	93.2	%
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity				Not Determined
Activity	=	55.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Potassium channel subfamily K member 2

External ID: CHEMBL3993351

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 3
First Page: 1076
Last Page: 1088
DOI: 10.1021/acs.jmedchem.6b01285

Target ChEMBL ID: CHEMBL2321615
ChEMBL Target Name: Potassium channel subfamily K member 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
FC	=	1.14
FC	=	2.64
FC	=	2.76
FC	=	1.05
FC	=	1.29
FC	=	1.23
FC	=	1.5
FC	=	1.6
FC	=	1.7
FC	=	1.37
FC	=	1.43
FC	=	1.44
FC	=	1.5
FC	=	1.62
FC	=	1.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3993354

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 3
First Page: 1076
Last Page: 1088
DOI: 10.1021/acs.jmedchem.6b01285

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	52.8	%
Inhibition	=	50.8	%
Inhibition	=	57.8	%
Inhibition	=	6.4	%
Inhibition	=	43.1	%
Inhibition	=	24.1	%
Inhibition	=	17.8	%
Inhibition	=	18	%
Inhibition	=	29.4	%
Inhibition	=	30.7	%
Inhibition	=	44.7	%
Inhibition	=	25.8	%
Inhibition	=	23.3	%
Inhibition	=	34	%
Inhibition	=	-39.8	%	Outside typical range
Inhibition	=	7.5	%
Inhibition	=	30.8	%
Inhibition	=	1.8	%

106988-34-5 靶点实验数据