HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL1909180

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL236
ChEMBL Target Name: Delta-type opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, inducible

External ID: CHEMBL1909179

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3464
ChEMBL Target Name: Nitric oxide synthase, inducible
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mu-type opioid receptor

External ID: CHEMBL1909182

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL233
ChEMBL Target Name: Mu-type opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Kappa-type opioid receptor

External ID: CHEMBL1909181

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL237
ChEMBL Target Name: Kappa-type opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909184

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909183

Protocol: N/A

Comment: Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cGMP-specific 3',5'-cyclic phosphodiesterase

External ID: CHEMBL1909186

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL1827
ChEMBL Target Name: cGMP-specific 3',5'-cyclic phosphodiesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
11.476	IC50	=	11476		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909185

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
11.59	IC50	=	11590		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M3

External ID: CHEMBL1909172

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL245
ChEMBL Target Name: Muscarinic acetylcholine receptor M3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
2.39E-4	Ki	=	0.239		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2

External ID: CHEMBL1909171

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL211
ChEMBL Target Name: Muscarinic acetylcholine receptor M2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5

External ID: CHEMBL1909174

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL2035
ChEMBL Target Name: Muscarinic acetylcholine receptor M5
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
0.32	IC50	=	320		nM
0.23	Ki	=	230		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M4

External ID: CHEMBL1909173

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL1821
ChEMBL Target Name: Muscarinic acetylcholine receptor M4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
2.066	IC50	=	2066		nM
0.288	Ki	=	288		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuropeptide Y receptor type 2

External ID: CHEMBL1909176

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4018
ChEMBL Target Name: Neuropeptide Y receptor type 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuropeptide Y receptor type 1

External ID: CHEMBL1909175

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4777
ChEMBL Target Name: Neuropeptide Y receptor type 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase 1

External ID: CHEMBL1909178

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL3048
ChEMBL Target Name: Nitric oxide synthase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909177

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
0.004123	Ki	=	4.123		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Interstitial collagenase

External ID: CHEMBL1909196

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL332
ChEMBL Target Name: Interstitial collagenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutrophil elastase

External ID: CHEMBL1909195

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL248
ChEMBL Target Name: Neutrophil elastase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein kinase C alpha type

External ID: CHEMBL1909198

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL299
ChEMBL Target Name: Protein kinase C alpha type
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans

External ID: HMS1625

Protocol: The fix-reporter plasmid was conjugated into this strain which the stably integrates into the chromosome using the mini-Tn7 system (PMID: 15908923). This plasmid consists of the fixK promoter, which is a target of the fixLJ pathway driving expression of GFP.
The day before screen an overnight culture of B. multivorans strain VC7102, with fix reporter, is set up in tryptic soy broth (TSB) at 37 degrees C with shaking. The day of the screen the overnight culture is diluted 1:100 in fresh tryptic soy broth.
The day of the screen, 30 microL of tryptic soy broth (TSB) is pipetted into columns 1-22 of a 384-well plate (Corning 3764) using the Combi multidrop dispenser. To column 24, 30 microL of TSB containing 78 microM of Benserazide TSB is added for a positive control. To column 23, 30 microL of TSB containing with DMSO (0.078% v/v in TSB) is added for a negative control. 300 nL of each compound are pin-transferred to each plate. For every compound plate 2 replicate assay plates are set up. 30 microL of the 1:100 diluted-B. multivorans strain VC7102 is added to each well using the Combi. Initial OD600 and GFP are measured using the PerkinElmer EnVision. Plates are stacked 5 high, covered with lids and incubated at 37 degrees C overnight (~18 h).
The following day, assay plates are read using a PerkinElmer EnVision (600 nm filter and GFP).
Positive control: Benserazide 39 microM in column 24 (No positive control was used for plates 2089 & 2090; Plates 2091-2093: columns 1 & 24)
Negative control: DMSO 300 nL/well in column 23 (For plates 2089 & 2090 negative controls were located in columns 2 & 24; plates 2091-2093: columns 2 & 23)

Comment: Analysis method:
For each compound well, the initial GFP value was subtracted from overnight GFP value to calculate the deltaGFP. The mean and standard deviation of the negative control wells deltaGFP (column 23) on both replicate plates was calculated. Wells with replicate average deltaGFP at least 3 standard deviations above the plate negative control deltaGFP average were scored as potential positives.

To determine activity scores, Z-scores were calculated for each replicate separately based on the replicate negative control deltaGFP plate average and standard deviation. The replicate average deltaGFP Z-scores were used for activity scores, with activity score of 100 set to Z-score = 4 and activity score = 0 (no activity) set to Z-score = 0. Z-scores > 4 were considered activity score = 100, and Z-scores < 0 were considered activity score = 0.

Avg_deltaGFP_Z-score	Absorbance_T0_A	GFP_T0_A	Absorbance_T0_B	GFP_T0_B	Absorbance_A	GFP_A	Absorbance_B	GFP_B	deltaGFP_A	deltaGFP_B	Avg_deltaGFP	deltaGFP_A_Z-score	deltaGFP_B_Z-score
-1.27	0.058	2540356	0.057	2547765	0.323	2653767	0.324	2670642	113411	122877	118144	-1.02538	-1.51489
0.67	0.06	2426612	0.06	2412710	0.332	2588935	0.334	2587049	162323	174339	168331	0.387734	0.95318
-0.33	0.059	2520773	0.059	2509075	0.354	2673282	0.353	2672667	152509	163592	158050	-0.303321	-0.354548
1	0.059	2468903	0.06	2466127	0.341	2639381	0.343	2657312	170478	191185	180832	0.740141	1.26456
0.74	0.106	2047221	0.107	2046542	0.568	2660762	0.571	2649109	613541	602567	608054	0.543696	0.932316
-0.66	0.092	2123400	0.091	2148341	0.529	2717562	0.527	2686607	594162	538266	566214	-0.115128	-1.20669
-2.8	0.084	2199147	0.086	2231265	0.513	2727386	0.51	2708166	528239	476901	502570	-2.3563	-3.24802
-1.96	0.11	2144558	0.109	2153923	0.5	2687675	0.492	2666280	543117	512357	527737	-1.8505	-2.06856
-1.14	0.104	2099367	0.101	2142517	0.523	2681778	0.518	2664243	582411	521726	552068	-0.514625	-1.7569
-1.27	0.06	2163951	0.06	2189032	0.479	2724714	0.479	2724846	560763	535814	548288	-1.25059	-1.28825
0.44	0.112	2063589	0.11	2102127	0.548	2685220	0.536	2678343	621631	576216	598924	0.818731	0.0557383
-2.91	0.08	2158004	0.079	2170268	0.457	2669594	0.457	2657682	511590	487414	499502	-2.92231	-2.8983
-0.49	0.095	2076005	0.096	2131985	0.526	2666805	0.524	2683829	590800	551844	571322	-0.229425	-0.755007
-0.9	0.062	2090554	0.062	2141637	0.497	2673509	0.491	2677205	582955	535568	559262	-0.496131	-1.29644
-0.25	0.116	2079590	0.115	2121566	0.524	2677549	0.525	2680407	597959	558841	578400	0.0139578	-0.522249
-2.52	0.062	2255876	0.061	2287219	0.513	2783828	0.509	2781307	527952	494088	511020	-2.36606	-2.67629
-0.99	0.065	2156875	0.064	2185148	0.514	2718354	0.514	2737090	561479	551942	556710	-1.22625	-0.751747
0.2	0.076	2248749	0.074	2236287	0.498	2854236	0.494	2844008	605487	607721	606604	0.425044	-0.0214336
-0.39	0.059	2155193	0.061	2158543	0.53	2739701	0.526	2750103	584508	591560	588034	-0.243403	-0.538384
2.08	0.08	2151673	0.079	2156007	0.528	2802359	0.525	2836180	650686	680173	665430	1.86521	2.29612

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Matrix metalloproteinase-9

External ID: CHEMBL1909197

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL321
ChEMBL Target Name: Matrix metalloproteinase-9
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 1

External ID: CHEMBL1909200

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4040
ChEMBL Target Name: Mitogen-activated protein kinase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 3

External ID: CHEMBL1909199

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL3385
ChEMBL Target Name: Mitogen-activated protein kinase 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein phosphatase 3 catalytic subunit alpha

External ID: CHEMBL1909202

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4445
ChEMBL Target Name: Protein phosphatase 3 catalytic subunit alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 14

External ID: CHEMBL1909201

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL260
ChEMBL Target Name: Mitogen-activated protein kinase 14
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
0.159	IC50	=	159		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909188

Protocol: N/A

Comment: Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet-activating factor receptor

External ID: CHEMBL1909187

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL250
ChEMBL Target Name: Platelet-activating factor receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-gated inwardly rectifying potassium channel KCNH2

External ID: CHEMBL1909190

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL240
ChEMBL Target Name: Voltage-gated inwardly rectifying potassium channel KCNH2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Translocator protein

External ID: CHEMBL650074

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 26
First Page: 5246
Last Page: 5256
DOI: 10.1021/jm960536o

Target ChEMBL ID: CHEMBL5742
ChEMBL Target Name: Translocator protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
555904	IC50	=	5.5590425727E8	nM	Outside typical range
142889	IC50	=	1.4288939585E8	nM	Outside typical range
2630.27	IC50	=	2630267.99	nM	Outside typical range
2857.59	IC50	=	2857590.54	nM	Outside typical range
76913	IC50	=	7.691304403E7	nM	Outside typical range
454988	IC50	=	4.5498806015E8	nM	Outside typical range
263027	IC50	=	2.6302679919E8	nM	Outside typical range
100000	IC50	=	100000000	nM	Outside typical range
106414	IC50	=	1.0641430182E8	nM	Outside typical range
55590.4	IC50	=	5.559042573E7	nM	Outside typical range
285759	IC50	=	2.8575905434E8	nM	Outside typical range
62517.3	IC50	=	6.251726928E7	nM	Outside typical range
10864.3	IC50	=	1.086425624E7	nM	Outside typical range
500035	IC50	=	5.0003453498E8	nM	Outside typical range
666807	IC50	=	6.6680676921E8	nM	Outside typical range
195884	IC50	=	1.9588446735E8	nM	Outside typical range
285759	IC50	=	2.8575905434E8	nM	Outside typical range
1614.36	IC50	=	1614358.56	nM	Outside typical range
23280.9	IC50	=	2.328091258E7	nM	Outside typical range
41686.9	IC50	=	4.168693835E7	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909189

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Angiotensin-converting enzyme

External ID: CHEMBL1909192

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4074
ChEMBL Target Name: Angiotensin-converting enzyme
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Progesterone receptor

External ID: CHEMBL1909191

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL1909044
ChEMBL Target Name: Progesterone receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin G

External ID: CHEMBL1909194

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4071
ChEMBL Target Name: Cathepsin G
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Caspase-1

External ID: CHEMBL1909193

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL4801
ChEMBL Target Name: Caspase-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL1909212

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
5.847	IC50	=	5847		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
6.9071	IC50	=	6907.1		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL1909211

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: 5-hydroxytryptamine receptor 2A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
2.991	Ki	=	2991		nM
10.469	IC50	=	10469		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
2.286	IC50	=	2286		nM
0.653	Ki	=	653		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
0.075	IC50	=	75		nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL1909214

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL251
ChEMBL Target Name: Adenosine receptor A2a
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit theta

External ID: CHEMBL650082

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 4
First Page: 715
Last Page: 724
DOI: 10.1021/jm00004a017

Target ChEMBL ID: CHEMBL2093872
ChEMBL Target Name: GABA-A receptor; anion channel
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
555904	IC50	=	5.5590425727E8	nM	Outside typical range
142889	IC50	=	1.4288939585E8	nM	Outside typical range
2630.27	IC50	=	2630267.99	nM	Outside typical range
2857.59	IC50	=	2857590.54	nM	Outside typical range
76913	IC50	=	7.691304403E7	nM	Outside typical range
454988	IC50	=	4.5498806015E8	nM	Outside typical range
263027	IC50	=	2.6302679919E8	nM	Outside typical range
100000	IC50	=	100000000	nM	Outside typical range
106414	IC50	=	1.0641430182E8	nM	Outside typical range
62517.3	IC50	=	6.251726928E7	nM	Outside typical range
10864.3	IC50	=	1.086425624E7	nM	Outside typical range
500035	IC50	=	5.0003453498E8	nM	Outside typical range
666807	IC50	=	6.6680676921E8	nM	Outside typical range
195884	IC50	=	1.9588446735E8	nM	Outside typical range
285759	IC50	=	2.8575905434E8	nM	Outside typical range
1614.36	IC50	=	1614358.56	nM	Outside typical range
23280.9	IC50	=	2.328091258E7	nM	Outside typical range
41686.9	IC50	=	4.168693835E7	nM	Outside typical range
20417.4	IC50	=	2.041737945E7	nM	Outside typical range
10423.2	IC50	=	1.042317429E7	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL1909213

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL226
ChEMBL Target Name: Adenosine receptor A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
2.95	IC50	=	2950		nM
1.721	Ki	=	1721		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909084

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
5.923	IC50	=	5923		nM
2.026	Ki	=	2026		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A3

External ID: CHEMBL1909215

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL256
ChEMBL Target Name: Adenosine receptor A3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1B adrenergic receptor

External ID: CHEMBL1909086

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL315
ChEMBL Target Name: Alpha-1B adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
0.119	IC50	=	119		nM
0.066	Ki	=	66		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1A adrenergic receptor

External ID: CHEMBL1909085

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL319
ChEMBL Target Name: Alpha-1A adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
0.224	IC50	=	224		nM
0.091	Ki	=	91		nM
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase Fyn

External ID: CHEMBL1909204

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL1841
ChEMBL Target Name: Tyrosine-protein kinase Fyn
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Epidermal growth factor receptor

External ID: CHEMBL1909203

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL203
ChEMBL Target Name: Epidermal growth factor receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：23209 靶标：N/A

External ID: UIHTS20180925

Protocol: Assay overview:
The purpose of this assay is to identify test compounds that differentially kill either epithelial cells or mesenchymal cells, critical components of EMT. The PC-3E+ and TEM4-18 cell lines, characterized as epithelial cells and mesenchymal cells respectively, were established in Henry Lab (Ref 1). For potential discriminative modulators of EMT, the two cells lines were labeled with GFP and mCherry respectively, and co-cultured together to eliminate those hits that non-discriminatingly kill both epithelial cells and mesenchymal cells by cytotoxicity irrelevant to the EMT properties.
Protocol for the EMT project:
The primary screening data were generated as described in HTS assay protocol table (Ref 2).

Table 1: HTS assay protocol table
Step Parameter Value Description
1. Plate cells 200 uL By MultiFlo. PC3E GFP 2,000 cells/ well and TEM418 mCherry 2,000 cells/well (1:1). Overnight incubation
2. Remove media Flip the plate
3. Add fresh media 150 uL By MultiFlo
4. Controls 200 uL C01-H01, C12 -H12, Hygromycin dose response from H to C were positive control. Wells A01, B01, A12 and B12 were negative control
5. Library 50 uL MSSP library 1 uM final from middle plate in full media
6. Incubation 72 hrs 37 C and 5% CO2
7. Assay readout GFP and mCherry channel imaging Perkin Elmer Operetta high content imaging system, with Harmony image analysis software.
8. Image analysis Green cells and Read cells counting Normalized to the average cell number of well B1 and B12 (no inhibition of cell viability) controls on each plate to get relative cell viability for each well.
9. Hit selection 11 hits The hit criteria for preferential cell killing are compounds that Redcells_Normalized is lower or equal 0.41, GreenCells_Normalized is higher or equal
0.55, RedCells/GreenCells_Normalized ratio is lower or equal 0.65, and Non-fluorescent by itself for Red cell killing OR Greencells_Normalized is
lower or equal 0.41, RedCells_Normalized is higher or equal 0.46, RedCells/GreenCells_Normalized ratio is higher or equal 1.8 and Non-fluorescent
by itself for Green cell killing.

The primary screening data (imaging data) were translated into Green or Red cell numbers in each well in the data file.

Comment: Preferential killing compounds are considered as active hits (score of 100) when meeting one of two groups of criteria:

1. Compounds that Redcells_Normalized is lower or equal 0.41, GreenCells_Normalized is higher or equal 0.55, RedCells/GreenCells_Normalized ratio is lower or equal 0.65, and Non-fluorescent by itself for Red cell killing.

OR

2. Greencells_Normalized is lower or equal 0.41, RedCells_Normalized is higher or equal 0.46, RedCells/GreenCells_Normalized ratio is higher or equal 1.8 and Non-fluorescent by itself for Green cell killing.

No. of GreenCells	No. of RedCells	GreenCells_Normalized	RedCells_Normalized	RedCells/GreenCells_Normalized
1789	1180	0.88	1.08	1.22
1961	1081	0.97	0.99	1.02
1876	1291	0.93	1.18	1.27
2244	1094	1.11	1	0.9
2275	1210	1.12	1.11	0.98
1995	1398	0.98	1.28	1.3
2123	1293	1.05	1.18	1.13
2281	1227	1.13	1.12	1
1964	1090	0.97	1	1.03
2110	1295	1.04	1.18	1.14
2342	1361	1.16	1.24	1.08
2014	1316	0.99	1.2	1.21
2021	1270	1	1.16	1.16
2160	1287	1.07	1.18	1.1
2022	1197	1	1.09	1.1
1798	1082	0.89	0.99	1.11
1938	1199	1.08	1.06	0.98
2000	1260	1.12	1.11	0.99
1971	1201	1.1	1.06	0.96
2100	1130	1.17	1	0.85

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein kinase Lck

External ID: CHEMBL1909206

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL258
ChEMBL Target Name: Tyrosine-protein kinase Lck
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
0.2938	IC50	=	293.8		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-2

External ID: CHEMBL1909205

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL1824
ChEMBL Target Name: Receptor tyrosine-protein kinase erbB-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: DrugMatrix

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	Activity Comment
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
18.896	IC50	=	18896		nM
	Ki					Note: corresponding IC50 reported as Active
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	Ki			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
	IC50			Not Active		Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1909208

Protocol: N/A

Comment: Data Source: DrugMatrix

Standard Type	Standard Text Value	Activity Comment
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
IC50	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured
Ki	Not Active	Inhibition < 50% @ 10 uM and thus dose-reponse curve not measured

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL844236

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 7
First Page: 1229
Last Page: 1239
DOI: 10.1021/jm00390a019

Standard Type	Standard Relation	Standard Value
Ratio	>	10000
Ratio	>	58000
Ratio	>	58000
Ratio	=	5.7
Ratio	<	0.0027
Ratio	<	0.012

106955-87-7 靶点实验数据