HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3362182

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3362180

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3362181

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3362186

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	34.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca fascicularis

External ID: CHEMBL3362187

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL613847
ChEMBL Target Name: Cynomolgus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	30.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3362185

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	89.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macaca fascicularis

External ID: CHEMBL3362190

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL613847
ChEMBL Target Name: Cynomolgus monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	4960	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3362188

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	7120	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL3362189

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
AUC	=	17100	ng.hr.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL3362194

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	21	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL3362195

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	59	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL3362198

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	78	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL3362197

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	45	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL3362200

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1.02	mg/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cavia porcellus

External ID: CHEMBL3362201

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL369
ChEMBL Target Name: Cavia porcellus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1.09	mg/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytosolic phospholipase A2

External ID: CHEMBL3361803

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL3816
ChEMBL Target Name: Cytosolic phospholipase A2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.13	IC50	=	130	nM
0.57	IC50	=	570	nM
0.058	IC50	=	58	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3361804

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Standard Type	Standard Relation	Standard Value
LogP	=	9.4
LogP	=	8.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3362178

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	26.6	%
Inhibition	=	30.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3362179

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3361805

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2014
Volume: 57
Issue: 17
First Page: 7244
Last Page: 7262
DOI: 10.1021/jm500494y

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined
0.54	IC50	=	540	nM
0.28	IC50	=	280	nM

1069046-00-9 靶点实验数据