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1045708-93-7 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1118305
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 8
First Page: 3227
Last Page: 3246
DOI: 10.1021/jm9018788
Standard TypeStandard RelationStandard ValueActivity Comment
pKa=9.9
pKa=9.9
pKa=9.6
pKa=9.9
pKa=9.9
pKa=9.6
pKa=7.2
pKa=6.1
pKa=8.3
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1118304
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 8
First Page: 3227
Last Page: 3246
DOI: 10.1021/jm9018788
Standard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
CL=420000mL.min-1.g-1Outside typical range
CL=43000mL.min-1.g-1Outside typical range
CL=68000mL.min-1.g-1Outside typical range
CL=50000mL.min-1.g-1Outside typical range
CL=27000mL.min-1.g-1Outside typical range
CL=150000mL.min-1.g-1Outside typical range
CL=580000mL.min-1.g-1Outside typical range
CL=580000mL.min-1.g-1Outside typical range
CL=22000mL.min-1.g-1Outside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Liver microsomes
External ID: CHEMBL1118303
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 8
First Page: 3227
Last Page: 3246
DOI: 10.1021/jm9018788

Target ChEMBL ID: CHEMBL613373
ChEMBL Target Name: Liver microsomes
ChEMBL Target Type: SUBCELLULAR - Target is a subcellular fraction
Relationship Type: S - Subcellular target assigned
Confidence: Target assigned is subcellular fraction
Standard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
CL=16000mL.min-1.g-1Outside typical range
CL=0mL.min-1.g-1
CL=0mL.min-1.g-1
CL=6000mL.min-1.g-1
CL=2000mL.min-1.g-1
CL=0mL.min-1.g-1
CL=13000mL.min-1.g-1Outside typical range
CL=100000mL.min-1.g-1Outside typical range
CL=6000mL.min-1.g-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1118302
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 8
First Page: 3227
Last Page: 3246
DOI: 10.1021/jm9018788
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
300000Solubility=300000000nM
24000Solubility=24000000nM
4Solubility<4000nM
980Solubility=980000nM
solubilityNot Determined
4Solubility=4000nM
10000Solubility=10000000nM
27000Solubility=27000000nM
36000Solubility=36000000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1118301
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 8
First Page: 3227
Last Page: 3246
DOI: 10.1021/jm9018788
Standard TypeStandard RelationStandard ValueActivity Comment
LogP=5
LogP=3.3
LogPNot Determined
LogP=2
LogP=2.4
LogP=3.9
LogP=3.6
LogP=-0.1
LogP=2
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1118300
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 8
First Page: 3227
Last Page: 3246
DOI: 10.1021/jm9018788
Standard TypeStandard RelationStandard ValueActivity Comment
LogD=2.5
LogD=0.8
LogDNot Determined
LogD=-0.5
LogD=-0.1
LogD=1.7
LogD=3.3
LogD=0.1
LogD=1