HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1

External ID: CHEMBL3380787

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL216
ChEMBL Target Name: Muscarinic acetylcholine receptor M1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanin-concentrating hormone receptor 1

External ID: CHEMBL3380786

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL344
ChEMBL Target Name: Melanin-concentrating hormone receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1B) dopamine receptor

External ID: CHEMBL3380789

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL1850
ChEMBL Target Name: Dopamine D5 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL3380788

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL2056
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A2a

External ID: CHEMBL3380791

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL251
ChEMBL Target Name: Adenosine A2a receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A1

External ID: CHEMBL3380790

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL226
ChEMBL Target Name: Adenosine A1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3388597

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2014
Volume: 24
Issue: 21
First Page: 5050
Last Page: 5054
DOI: 10.1016/j.bmcl.2014.09.028

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
725	IC50	=	725000	nM	Outside typical range
6338	IC50	=	6338000	nM	Outside typical range
681783	IC50	=	681783000	nM	Outside typical range
9590000	IC50	=	9590000000	nM	Outside typical range
1727620	IC50	=	1727617000	nM	Outside typical range
77986	IC50	=	77986000	nM	Outside typical range
12	IC50	=	12000	nM
11	IC50	=	11000	nM
387	IC50	=	387000	nM	Outside typical range
18450	IC50	=	18450000	nM	Outside typical range
302180	IC50	=	302180000	nM	Outside typical range
191	IC50	=	191000	nM	Outside typical range
2815900	IC50	=	2815900000	nM	Outside typical range
96650	IC50	=	96650000	nM	Outside typical range
214777	IC50	=	214777000	nM	Outside typical range
4232	IC50	=	4232000	nM	Outside typical range
115160	IC50	=	115160000	nM	Outside typical range
113000	IC50	=	113000000	nM	Outside typical range
6103	IC50	=	6103000	nM	Outside typical range
190000	IC50	=	190000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Parathyroid hormone/parathyroid hormone-related peptide receptor

External ID: CHEMBL3380793

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL1793
ChEMBL Target Name: Parathyroid hormone receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adenosine receptor A3

External ID: CHEMBL3380792

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL256
ChEMBL Target Name: Adenosine A3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuropeptide Y receptor type 5

External ID: CHEMBL3380795

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL4561
ChEMBL Target Name: Neuropeptide Y receptor type 5
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：C5a anaphylatoxin chemotactic receptor 1

External ID: CHEMBL3380794

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL2373
ChEMBL Target Name: C5a anaphylatoxin chemotactic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucagon receptor

External ID: CHEMBL3380796

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL1985
ChEMBL Target Name: Glucagon receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuromedin-U receptor 2

External ID: CHEMBL3377680

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL1075144
ChEMBL Target Name: Neuromedin-U receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
1.2	EC50	=	1200	nM
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active
6.1	EC50	=	6100	nM
37.3	EC50	=	37300	nM
31.1	EC50	=	31100	nM
14	EC50	=	14000	nM
	EC50				Not Active
	EC50				Not Active
	EC50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adrenocorticotropic hormone receptor

External ID: CHEMBL3377682

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL1965
ChEMBL Target Name: Melanocortin receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocyte-stimulating hormone receptor

External ID: CHEMBL3377681

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL3795
ChEMBL Target Name: Melanocortin receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocortin receptor 4

External ID: CHEMBL3377684

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL259
ChEMBL Target Name: Melanocortin receptor 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocortin receptor 3

External ID: CHEMBL3377683

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL4644
ChEMBL Target Name: Melanocortin receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Adrenocorticotropic hormone receptor

External ID: CHEMBL3377686

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL2279
ChEMBL Target Name: Melanocortin receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocyte-stimulating hormone receptor

External ID: CHEMBL3377685

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL4077
ChEMBL Target Name: Melanocortin receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocortin receptor 4

External ID: CHEMBL3377688

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL3719
ChEMBL Target Name: Melanocortin receptor 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocortin receptor 3

External ID: CHEMBL3377687

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL4774
ChEMBL Target Name: Melanocortin receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase II subunit alpha

External ID: CHEMBL2447759

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 21
First Page: 6681
Last Page: 6689
DOI: 10.1016/j.bmc.2013.08.013

Target ChEMBL ID: CHEMBL2095191
ChEMBL Target Name: Casein kinase II
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	77	%
Activity	=	66	%
Activity	=	50	%
Activity	=	64	%
Activity	=	86	%
Activity	=	80	%
Activity	=	0.8	%
Activity	=	73	%
Activity	=	73	%
Activity	=	39	%
Activity	=	35	%
Activity	=	1.1	%
Activity	=	49	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuromedin-U receptor 1

External ID: CHEMBL3380783

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL1075178
ChEMBL Target Name: Neuromedin-U receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase II subunit alpha

External ID: CHEMBL2447758

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 21
First Page: 6681
Last Page: 6689
DOI: 10.1016/j.bmc.2013.08.013

Target ChEMBL ID: CHEMBL2095191
ChEMBL Target Name: Casein kinase II
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.25	IC50	=	250	nM
0.8	IC50	=	800	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
26	IC50	=	26000	nM
19	IC50	=	19000	nM
23	IC50	=	23000	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
30	IC50	>	30000	nM
2.2	IC50	=	2200	nM
0.18	IC50	=	180	nM
2	IC50	=	2000	nM
0.09	IC50	=	90	nM
30	IC50	>	30000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Melanocortin receptor 5

External ID: CHEMBL3380782

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL4489
ChEMBL Target Name: Melanocortin receptor 5
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：15621 靶标：G protein-activated inward rectifier potassium channel 2

External ID: VANDERBILT_HTS_GIRK2_MPD

Protocol: To screen for modulators of the G protein-gated inwardly-rectifying potassium channel subunit 2 (GIRK2) homomeric channels, HEK293 cells were engineered to overexpress GIRK2. These cells were screened using a high-throughput thallium-flux assay in a 384-well format. High-throughput thallium flux assays are based on three principles: (1) extracellular thallium can permeate through potassium channels into cells, (2) the fluorescent dye Thallos enters and stays in the cytoplasm of HEK293 cells, and (3) the fluorescence of Thallos increases dramatically when it interacts with thallium ions. Compounds that modulate the activity of an overexpressed channel, in this case GIRK2, are identified by the change in fluorescence that results from changes in thallium influx into cells through the overexpressed channel.

The screening protocol was conducted as follows. One hour prior to screening, cells were loaded with 1.5 micromolar (muM) Thallos in assay buffer (1x Hank's Balanced Salt Solution and 20 millimolar (mM) HEPES). The liquid handling and imaging was conducted using a kinetic-imaging plate reader, Panoptic (WaveFront Biosciences). Before screening, Thallos-containing buffer was removed from cells and replaced with 20 microliters (muL) per well of assay buffer. Compounds were dissolved in assay buffer at 20 muM. After 8 seconds of imaging, 20 muL of compound solution was added per well and allowed to incubate for 150 seconds. Next, 10 muL of a solution containing 2.0 mM thallium in Base Buffer (125 mM NaHCO3, 1 mM MgSO4, 1.8 mM CaSO4, 5mM Glucose, and 20 mM HEPES) was added to the wells. 30 seconds later, 12 muL of base buffer containing 2.0 mM thallium and 50 mM 2-methyl-2,4-pentanediol (MPD), a partially-activating concentration, was added to each well. MPD has is a previously-described GIRK2 channel activator. Data was collected for 60 seconds after this final addition. The positive control for this screen was 30 muM ivermectin, a natural product previously identified as a GIRK2 activator as part of a small-scale pilot screen. Microsoft Excel was utilized for data analysis. Data were normalized, F/Fo, on a well-to-well basis to account for differences in cell number. Compound activity was analyzed by comparing the sums of control-subtracted amplitudes of fluorescence intensity at 20 seconds after each thallium addition. The top 0.2% compounds corresponding to wells that demonstrated the largest increases in fluorescence were selected as "hits" for counter screening, as described below.

All 63,228 compounds screened using the method described above are listed in column OUTCOME_SCREEN_HITS. The 133 compounds selected as hits based on the above criteria are labelled with "100" in the ACTIVITY column. Fluorescent compounds were included in the inactive compounds and marked with "0" in the ACTIVITY column.

The 133 active compounds from column OUTCOME_SCREEN_HITS were tested for non-specific activity in untransfected HEK293 cells using assay conditions otherwise identical to the primary screen. Column OUTCOME_HEK_COUNTERSCREEN lists the 23 compounds that displayed an increase in fluorescence upon thallium addition with "100" in the ACTIVITY column.

The 110 compounds which were identified as hits in the primary screen but inactive when tested in untransfected HEK293 cells were tested for activity in GIRK2-overexpressing HEK293 cells that did not express NPY4 receptor. Column OUTCOME_GIRK2_COUNTERSCREEN lists the 44 compound that displayed an increase in fluorescence upon thallium addition with "100" in the ACTIVITY column.

The 44 active compounds from column OUTCOME_GIRK2_COUNTERSCREEN were tested at various concentrations to determine if compound activity was concentration dependent. Column OUTCOME_GIRK2_DOSE_RESPONSE provides the efficacy of these compounds; activity of all compounds at the provided concentrations was normalized to the activity of VU0537695 at 25 muM, which was the highest efficacy observed during this screening. For each compound concentration listed, the efficacy of that compound provided refers to the normalized, control-subtracted fluorescence intensity at 15 seconds after the addition of thallium. The 28 compounds that demonstrated >5% efficacy and concentration-dependent activity were labelled as "100" in the ACTIVITY column.

Finally, column PUBCHEM_ACTIVITY_OUTCOME combines all of the information from the above counterscreens together, indicating the 28 hits from this GIRK2 screen.

Comment:

OUTCOME_SCREEN_HITS	OUTCOME_HEK_COUNTERSCREEN	OUTCOME_GIRK2_COUNTERSCREEN	OUTCOME_GIRK2_DOSE_RESPONSE	% Efficacy @ 25uM	% Efficacy @ 8.3uM	% Efficacy @ 2.8uM	% Efficacy @ 0.94uM	% Efficacy @ 0.15uM	% Efficacy @ 0.024uM
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Orexin receptor type 2

External ID: CHEMBL3380785

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL4792
ChEMBL Target Name: Orexin receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL3380784

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 21
First Page: 6117
Last Page: 6123
DOI: 10.1016/j.bmc.2014.08.038

Target ChEMBL ID: CHEMBL225
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：24983 靶标：Huntingtin

External ID: KUHTS-Muma KU-CaM-Htt INH-01

Protocol: 1; Dispense 45 nl compounds (10 mM stocks) using ECHO 555 to Alpha 384 well assay plates. Dispense 45 nl DMSO to control columns 1 and 2 of 384 well plates.
2; Incubate 5 ul of 6XHis-mHTT (Final, 13 nM) with the compounds for 40 mins at room temperature in buffer containing 10 mM Tris.HCl pH 7.4, 1 mM calcium chloride, 150 mM sodium chloride, 0.1% BSA and 20% glycerol.
3; Dispense 5 ul of 6XGST-CaM (Final 13 nM) in buffer A.
4; Incubation; 1 hour (dark at 25C)
5; Dispense 20 ul of Nickel chelate acceptor beads (Final, 20 ugs/ml) and Glutathione donor beads (Final, 30 ugs/ml). Incubate for 2h, room temperature.
6; Detector: Perkin Elmer Enspire, Alphascreen Module (Excitation 680nm/Emission 570nm).

NOTES (numbers refer to Sequence numbers above)
1. Alphascreen bead incubations were performed in green light, TiterTek setting 400rpm.
2. All incubation and addition steps were followed by mixing and centrifugation at 400g,1 min.
3. The percent inhibition for each compound was calculated as follows:
100- [100 *((Test Compound-Median Low Control) / (Median High Control - Median Low Control))]

Where:
Test_Compound is defined as wells containing His mHTT + GST CaM in the presence of test compound

High_Control is defined as wells containing His mHTT + GST CaM and DMSO.

Low_Control is defined as wells containing His mHTT and DMSO.

Comment: All percent inhibition data reported were normalized to high and low controls on a per-plate basis. The results of primary screening data include compounds contributing to assay signal interference, interference with tags binding to Alpha beads, chelators, process related artifacts etc.. The actives were defined as compounds that inhibited Alphascreen reads to greater than 50%.

Activity at 15 uM	Phenotype
-3.1
4.2
-4.8
-0.6
-3.9
-6
75.3	Inhibitor
-10.3
-7
-2
-3.8
17.6
-4.8
-4.1
-7.8
-7.5
15.2
7.8
-2.5
-13.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters 靶标：Stargazin (mouse)

External ID: WaveGuideAssay:441

Protocol: For initial screening, TetON human embryonic kidney cells (HEK293) expressing GluA2 and stargazin, gamma-2, were plated in 384-well BD purecoat amine-coated plates at 16k cells/well. Cells were induced with 8 ug/mL doxycycline in the presence of 30 uM NBQX and incubated O/N at 37deg in 5% CO2. They were washed with Hank's Balanced Salt Solution (HBSS) containing 20 mM HEPES, pH 7.4 and FLIPR VSD dye solution was added and incubated on the cells at room temperature for 45 minutes. The cell plate was loaded into the Hamamatsu Functional Drug Screening System 6000 (FDSS), 10 seconds of background were collected before addition of compound at 30 uM final concentration. Data collection continued at 1Hz sampling and experimentally determined EC50 glutamate stimulus was added at 300 seconds. Controls of 1 mM glutamate (maximal effect) and NBQX (antagonist) were used to calculate a Z' score per plate.

Data were processed using the Vanderbilt screening analysis platform, WaveGuide. Data were normalized by dividing the raw fluorescence for all time points by an average of the baseline fluorescence. For each well, 4 values were calculated as follows:

1. CMPDslope was the slope of the normalized value within the timeframe 11-18 seconds,
2. CMPDmaxmin was the difference in maximal and minimal normalized value within the timeframe 8-100 seconds
3. GLUslope was the slope of the normalized value within the timeframe 310-315 seconds, and
4. GLUmaxmin was the difference in maximal and minimal normalized value within the timeframe 301-380 seconds.

Compounds were marked as hits where any of the above calculated results for a compound differed by at least three standard deviations from the mean for that calculation across all compounds in the plate.

Compounds denoted as 'hits' were given the score of '100' and outcome of 'active'. All other compounds were denoted as 'inactive' and given a score of '0'.

Comment:

Bioactivity outcome comment	Glumaxmin	pctMAX	GluSlope	CMPDSlope	CMPDmaxmin	BaselineReturn	pctMAXslope	Glumaxmin_mean_MAX	Glumaxmin_stddev_MAX	pctMAX_mean_MAX	pctMAX_stddev_MAX	GluSlope_mean_MAX	GluSlope_stddev_MAX	CMPDSlope_mean_MAX	CMPDSlope_stddev_MAX	BaselineReturn_mean_MAX	BaselineReturn_stddev_MAX	pctMAXslope_mean_MAX	pctMAXslope_stddev_MAX	Glumaxmin_mean_VHL	Glumaxmin_stddev_VHL	pctMAX_mean_VHL	pctMAX_stddev_VHL	GluSlope_mean_VHL	GluSlope_stddev_VHL	CMPDSlope_mean_VHL	CMPDSlope_stddev_VHL	BaselineReturn_mean_VHL	BaselineReturn_stddev_VHL	pctMAXslope_mean_VHL	pctMAXslope_stddev_VHL	Glumaxmin_mean_NBQX	Glumaxmin_stddev_NBQX	pctMAX_mean_NBQX	pctMAX_stddev_NBQX	GluSlope_mean_NBQX	GluSlope_stddev_NBQX	CMPDSlope_mean_NBQX	CMPDSlope_stddev_NBQX	BaselineReturn_mean_NBQX	BaselineReturn_stddev_NBQX	pctMAXslope_mean_NBQX	pctMAXslope_stddev_NBQX	Glumaxmin_mean_EC50	Glumaxmin_stddev_EC50	pctMAX_mean_EC50	pctMAX_stddev_EC50	GluSlope_mean_EC50	GluSlope_stddev_EC50
Inactive	0.307925602862406	32.0313314448044	1.88437069751112E-5	-2.88279138815798E-6	0.0860203671162111	-0.0473486051418853	59.3532292079311	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.290657584242576	29.9681281291992	2.14120073293302E-5	-2.01926632261843E-6	0.0737401138577924	-0.0224640805774035	67.9667335538074	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.300454704442112	31.1386996535925	2.11534775653923E-5	-4.89932335853874E-6	0.132922438798619	-0.104801071222897	67.0996826103462	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.283443348414052	29.1061626884232	2.04764823327379E-5	-3.71052183375265E-6	0.100798889607018	-0.054707338694582	64.8291921791834	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Active	0.159063510438705	14.2451123412521	1.23736767907725E-5	-5.11418311448796E-6	0.145337511476588	-0.126964991417508	37.6541966087243	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.270565212792215	27.5674677924566	1.58755888722537E-5	-4.57565136481408E-6	0.162897552977681	-0.160601265822785	49.3988256522724	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.277723151953747	28.422706840787	1.69581465173563E-5	-3.95840815035629E-6	0.129669033057364	-0.111289846807339	53.0294816094057	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.240367821242029	23.9594476865814	1.50377212556125E-5	-3.90630495329076E-6	0.119000501989288	-0.104606685169743	46.5888052645274	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.275899996582832	28.2048740778656	1.66888017505881E-5	-1.76633252300691E-6	0.0991598038545654	-0.0900060654729361	52.1261595679296	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.3054652026588	31.7373599145695	1.77217317407455E-5	-1.72812055867267E-7	0.0615123814178843	-0.0113602200278913	55.5903754820032	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.301077187663622	31.2130746861196	1.95944597223501E-5	-1.87892764596737E-6	0.105055702740916	-0.0819215631673592	61.8710858287105	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.296062751290573	30.6139438895564	1.99452757984663E-5	-4.48846583659991E-6	0.122591567128481	-0.110650541391703	63.0476444003224	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.271242199952128	27.6483550200944	1.71203962456755E-5	-3.36341632737126E-6	0.136815112656534	-0.117388053193404	53.5736308704914	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.27871626288019	28.5413649104422	1.89434752517081E-5	-4.63317122595513E-6	0.163954805381364	-0.145630749468217	59.6878296695308	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.290153169587839	29.9078600688614	1.85304371188737E-5	-5.33240863331885E-6	0.156104495446866	-0.140662049228533	58.3025922511979	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.298745003637127	30.9344225765752	1.85215781512018E-5	-2.71541230270632E-6	0.109771873382978	-0.0848256803677623	58.2728812571483	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.301003338306326	31.2042510774483	1.75264269239369E-5	-2.15470854603906E-6	0.106225719729981	-0.0714449253312456	54.935366855155	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.282990962536469	29.0521110879987	1.7463200513485E-5	-2.88740753434109E-6	0.127085483958898	-0.104332671512206	54.7233196308859	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.328664455531888	34.5092341232499	1.9184613549304E-5	-5.77579804270117E-6	0.145879497919913	-0.113602410327524	60.4965535288281	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6
Inactive	0.296141214010587	30.6233187082688	1.87153193401078E-5	-4.76251434991042E-6	0.155274330611945	-0.13919800268356	58.9226458261074	0.876790641658573	0.054521778860061	100	6.51432670958531	3.09634101332233E-5	2.27782570203395E-6	-4.17627712382558E-6	1.55062041253073E-6	-0.0778624059876154	0.0163032324323551	100	7.63931739969116	0.0398387770884933	0.0060114263453128	1.88737914186277E-16	0.718252339207191	1.1462735638481E-6	2.24102815382179E-6	-3.84292098153968E-6	6.88990503927857E-7	-0.0796199695219915	0.0123217627017518	2.22044604925031E-17	7.51590666195466	0.12849434285856	0.00791817185586392	10.5926719950145	0.946072551010002	-6.17125318143313E-6	1.73316648226419E-6	-3.67225401912487E-6	7.98533790902206E-7	-0.0856785014075449	0.0109810110440722	-24.5413463102187	5.81265232572432	0.230933766772514	0.0369530138527891	22.8322556855981	4.41518985942769	1.53683416783816E-5	2.15218589787257E-6

101442-35-7 靶点实验数据