HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutrophil cytosol factor 1

External ID: CHEMBL4381025

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 3
First Page: 1156
Last Page: 1177
DOI: 10.1021/acs.jmedchem.9b01492

Target ChEMBL ID: CHEMBL1613743
ChEMBL Target Name: Neutrophil cytosol factor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
63	Ki	=	63000	nM
1520	Ki	=	1520000	nM
428	Ki	=	428000	nM
594	Ki	=	594000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
1370	Ki	=	1370000	nM
1380	Ki	=	1380000	nM
302	Ki	=	302000	nM
1250	Ki	=	1250000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
2000	Ki	>	2000000	nM
583	Ki	=	583000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Phospholipase D1

External ID: CHEMBL998623

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 8
First Page: 2240
Last Page: 2243
DOI: 10.1016/j.bmcl.2009.02.125

Target ChEMBL ID: CHEMBL2536
ChEMBL Target Name: Phospholipase D1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.9	IC50	=	1900	nM
2.1	IC50	=	2100	nM
0.15	IC50	=	150	nM
5.9	IC50	=	5900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-4

External ID: CHEMBL750233

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 23
First Page: 3946
Last Page: 3955
DOI: 10.1021/jm010901y

Target ChEMBL ID: CHEMBL1907596
ChEMBL Target Name: Neuronal acetylcholine receptor; alpha4/beta2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>	10000	nM
0.022	Ki	=	22	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
0.6	Ki	=	600	nM
0.0045	Ki	=	4.5	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
0.09	Ki	=	90	nM
0.18	Ki	=	180	nM
0.853	Ki	=	853	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
0.8	Ki	=	800	nM
0.04	Ki	=	40	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
1.2	Ki	=	1200	nM
1.2	Ki	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5342441

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 10
First Page: 6523
Last Page: 6541
DOI: 10.1021/acs.jmedchem.3c00034

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
56	Kd	=	56000	nM
0.068	Kd	=	68	nM
49	Kd	=	49000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-2 adrenergic receptor

External ID: CHEMBL2445017

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med. Chem. Lett.
Year: 2013
Volume: 4
Issue: 10
First Page: 1005
Last Page: 1010
DOI: 10.1021/ml400312j

Target ChEMBL ID: CHEMBL210
ChEMBL Target Name: Beta-2 adrenergic receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0842	Kd	=	84.2	nM
8	Kd	=	8000	nM
1.8	Kd	=	1800	nM
67.1	Kd	=	67100	nM
0.3483	Kd	=	348.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutrophil cytosol factor 1

External ID: CHEMBL4381035

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 3
First Page: 1156
Last Page: 1177
DOI: 10.1021/acs.jmedchem.9b01492

Target ChEMBL ID: CHEMBL1613743
ChEMBL Target Name: Neutrophil cytosol factor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Rmax	<	20	%
Rmax	>=	20	%
Rmax	>=	20	%
Rmax	>=	20	%
Rmax	<	20	%
Rmax	>=	20	%
Rmax	>=	20	%
Rmax	>=	20	%
Rmax	>=	20	%

1008-91-9 靶点实验数据