HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL957595

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1885
Last Page: 1902
DOI: 10.1021/jm801354e

Target ChEMBL ID: CHEMBL225
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	100	%
Emax	=	124	%
Emax	=	69	%
Emax	=	108	%
Emax	=	102	%
Emax	=	96	%
Emax	=	104	%
Emax	<=	12	%
Emax	=	116	%
Emax	=	90	%
Emax	=	87	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B

External ID: CHEMBL957593

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1885
Last Page: 1902
DOI: 10.1021/jm801354e

Target ChEMBL ID: CHEMBL1833
ChEMBL Target Name: Serotonin 2b (5-HT2b) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	100	%
Emax	=	92	%
Emax	<=	12	%
Emax	=	111	%
Emax	=	72	%
Emax	=	93	%
Emax	=	20	%
Emax	=	6	%
Emax	=	102	%
Emax	=	74	%
Emax	=	51	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL957594

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1885
Last Page: 1902
DOI: 10.1021/jm801354e

Target ChEMBL ID: CHEMBL225
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.128	EC50	=	128	nM
0.003	EC50	=	3	nM
0.011	EC50	=	11	nM
3.019	EC50	=	3019	nM
	Activity				Not Active
0.634	EC50	=	634	nM
	Activity				Not Active
3.416	EC50	=	3416	nM
0.023	EC50	=	23	nM
0.016	EC50	=	16	nM
0.902	EC50	=	902	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL957591

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1885
Last Page: 1902
DOI: 10.1021/jm801354e

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.774	EC50	=	774	nM
0.091	EC50	=	91	nM
0.349	EC50	=	349	nM
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
	Activity				Not Active
1.606	EC50	=	1606	nM
0.613	EC50	=	613	nM
	Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B

External ID: CHEMBL957592

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1885
Last Page: 1902
DOI: 10.1021/jm801354e

Target ChEMBL ID: CHEMBL1833
ChEMBL Target Name: Serotonin 2b (5-HT2b) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.459	EC50	=	459	nM
0.022	EC50	=	22	nM
0.014	EC50	=	14	nM
10	EC50	>	10000	nM
	Activity				Not Active
10	EC50	>	10000	nM
	Activity				Not Active
	Activity				Not Active
0.053	EC50	=	53	nM
0.075	EC50	=	75	nM
	Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL957590

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 7
First Page: 1885
Last Page: 1902
DOI: 10.1021/jm801354e

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	100	%
Emax	=	26	%
Emax	<=	12	%
Emax	=	79	%
Emax	<=	12	%
Emax	=	74	%
Emax	<=	12	%
Emax	<=	12	%
Emax	=	76	%
Emax	=	55	%
Emax	=	26	%

1007-08-5 靶点实验数据