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100-82-3 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Replicase polyprotein 1ab
External ID: CHEMBL5346746
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 3
First Page: 1015
Last Page: 1021
DOI: 10.1039/d3md00719g

Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
0.077IC50=77nM
0.052IC50=52nM
0.045IC50=45nM
0.034IC50=34nM
0.028IC50=28nM
0.00181IC50=1.81nM
0.05IC50=50nM
0.982IC50=982nM
0.077IC50=77nM
0.062IC50=62nM
IC50Not Active
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Phenylethanolamine N-methyltransferase
External ID: CHEMBL759748
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 2
First Page: 433
Last Page: 444
DOI: 10.1021/jm00397a029

Target ChEMBL ID: CHEMBL2331
ChEMBL Target Name: Phenylethanolamine N-methyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
3820000pI50=3.82M
4000000pI50=4M
3120000pI50=3.12M
5070000pI50=5.07M
6230000pI50=6.23M
4070000pI50=4.07M
4370000pI50=4.37M
5170000pI50=5.17M
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Phenylethanolamine N-methyltransferase
External ID: CHEMBL759749
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 2
First Page: 433
Last Page: 444
DOI: 10.1021/jm00397a029

Target ChEMBL ID: CHEMBL2331
ChEMBL Target Name: Phenylethanolamine N-methyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard Value
pKa=9.51
pKa=9.54
pKa=9.3
pKa=9.45
pKa=9.04
pKa=9.38
pKa=9.01
pKa=7.35
pKa=9.14
pKa=9.13
pKa=8.98
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Phenylethanolamine N-methyltransferase
External ID: CHEMBL821668
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 8
First Page: 1104
Last Page: 1109
DOI: 10.1021/jm00362a003

Target ChEMBL ID: CHEMBL4617
ChEMBL Target Name: Phenylethanolamine N-methyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
pI50=4.82M l-1
pI50=4.97M l-1
pI50=2.78M l-1
pI50=6.82M l-1
pI50=5.64M l-1
pI50=3.16M l-1
pI50=3.17M l-1
pI50=5.2M l-1
pI50=3.82M l-1
pI50=3.87M l-1
pI50=3.93M l-1
pI50=4M l-1
pI50=3.12M l-1
pI50=4.66M l-1
pI50=5.07M l-1
pI50=4.08M l-1
pI50=4.17M l-1
pI50=6.23M l-1
pI50=4.07M l-1
pI50=4.24M l-1