478-84-2

• 常用中文名：(8β)-2-Bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carbox amide
• 常用英文名：(8β)-2-Bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carbox amide
• CAS号：478-84-2
• 分子式：C₂₀H₂₄BrN₃O
• 分子量：402.32800
• 发布时间：2016-10-28 09:15:14
• 更新时间：2024-01-27 21:24:57

名称

• 英文名: (8β)-2-Bromo-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carbox amide
• 英文别名: Bromolysergide; 6-Bromo-3-pyridylmethyl bromide; 2-bromo-lysergide; 2-bromo-5-pyridylmethyl bromide; 2-bromo-6-methyl-9,10-didehydro-ergoline-8-carboxylic acid diethylamide; 2-Brom-lysergsaeurediethylamid; 2-bromo-5-bromoethylpyridine; 2-bromo-5-bromomethylpyridine; 2-bromo-5R,8R-lysergic acid diethyl amide

物化性质

• 密度: 1.44g/cm3
• 沸点: 580.7ºC at 760mmHg
• 分子式: C₂₀H₂₄BrN₃O
• 分子量: 402.32800
• 闪点: 305ºC
• 精确质量: 401.11000
• PSA: 39.34000
• LogP: 3.60640
• 蒸汽压: 1.77E-13mmHg at 25°C
• 折射率: 1.676
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KE2625000 CHEMICAL NAME : Ergoline-8-beta-carboxamide, 2-bromo-9,10-didehydro-N,N-diethyl-6-methyl- CAS REGISTRY NUMBER : 478-84-2 LAST UPDATED : 199106 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C20-H26-Br-N3-O MOLECULAR WEIGHT : 404.40 WISWESSER LINE NOTATION : T C6656 1A P GN LN CUTT&&J EVN2&2 G1 KE L1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 75 ug/kg TOXIC EFFECTS : Vascular - regional or general arteriolar or venous dilation REFERENCE : PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 1,20,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 6 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - body temperature increase REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 66,668,1957 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 158,265,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 158,265,1967

合成路线

50-37-3 ~73% 478-84-2

文献：Stanovnik, Branko; Tisler, Miha; Jurgec, Milan; Rucman, Rudolf Heterocycles, 1981 , vol. 16, # 5 p. 741 - 745