660847-06-3

• 常用中文名：(S)-6-乙酰氨基-2-(2-((S)-2-乙酰氨基-4-甲基戊酰胺基)乙酰氨基)-N-(4-甲基-2-氧代-2H-色烯-7-基)己酰胺
• 常用英文名：HDAC inhibitor
• CAS号：660847-06-3
• 分子式：C₂₈H₃₉N₅O₇
• 分子量：557.639
• 发布时间：2016-06-07 10:46:42
• 更新时间：2026-08-14 07:51:23

名称

• 中文名: (S)-6-乙酰氨基-2-(2-((S)-2-乙酰氨基-4-甲基戊酰胺基)乙酰氨基)-N-(4-甲基-2-氧代-2H-色烯-7-基)己酰胺
• 英文名: (2S)-6-acetamido-2-[[2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]acetyl]amino]-N-(4-methyl-2-oxochromen-7-yl)hexanamide
• 中文别名: N-乙酰基-L-亮氨酰甘氨酰-N6-乙酰基-N-(4-甲基-2-氧代-2H-1-苯并吡喃-7-基)-L-赖氨酰胺; (S)-6-乙酰氨基-2-(2-((S)-2-乙酰氨基-4-甲基戊酰胺基)乙酰氨基)-N-(4-甲基-2-氧代-2H-色烯-7-基)己酰胺 660-3
• 英文别名: N-Acetyl-L-leucylglycyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide; N-Acetyl-L-leucylglycyl-N6-acetyl-N-(4-Methyl-2; (S)-6-Acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chro; (2S)-6-Acetamido-2-[[2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]acetyl]amino]-N-(4-methyl-2-oxochromen-7-yl)hexanamide; L-Lysinamide, N-acetyl-L-leucylglycyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl); HDAC inhibitor/(S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide; Ac-Leu-Gly-Lys(Ac)-(7-amino-4-methylcoumarin); HDAC-IN-21; (S)-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)-6-(2,2,2-trifluoroacetamido)hexanamide; Ac-Leu-Gly-Lys (Ac)-AMC; Ac-Leu-Gly-Lys(Ac)-AMC; (S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide; N-Acetyl-L-leucylglycyl-N-acetyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; cc-560

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 980.1±65.0 °C at 760 mmHg
• 分子式: C₂₈H₃₉N₅O₇
• 分子量: 557.639
• 闪点: 546.5±34.3 °C
• 精确质量: 557.284973
• PSA: 193.16000
• LogP: 1.06
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.557
• 储存条件: 室温，干燥密封

合成路线

1379469-23-4 108-24-7 ~% 660847-06-3

文献：Madsen, Andreas S.; Olsen, Christian A. Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590

1379469-22-3 ~% 660847-06-3

文献：Madsen, Andreas S.; Olsen, Christian A. Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590

26093-31-2 ~% 660847-06-3

文献：Madsen, Andreas S.; Olsen, Christian A. Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590

1188-21-2 ~% 660847-06-3

文献：Madsen, Andreas S.; Olsen, Christian A. Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590

71989-26-9 ~% 660847-06-3

文献：Madsen, Andreas S.; Olsen, Christian A. Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5582 - 5590

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