849068-50-4

• 常用中文名：6-氯-吡咯并[2,3-b]吡啶-1-羧酸乙酯
• 常用英文名：ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
• CAS号：849068-50-4
• 分子式：C₁₀H₉ClN₂O₂
• 分子量：224.644
• 发布时间：2018-12-18 09:36:24
• 更新时间：2025-08-26 11:11:22

名称

• 中文名: 6-氯-吡咯并[2,3-b]吡啶-1-羧酸乙酯
• 英文名: ethyl 6-chloropyrrolo[2,3-b]pyridine-1-carboxylate
• 英文别名: 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 6-chloro-, ethyl ester; Ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 6-Chloro-1-ethoxycarbonyl-7-azaindole; 6-chloro-pyrrolo[2,3-b]pyridine-1-carboxylic acid ethyl ester; 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid,6-chloro-,ethyl ester

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 343.8±45.0 °C at 760 mmHg
• 分子式: C₁₀H₉ClN₂O₂
• 分子量: 224.644
• 闪点: 161.7±28.7 °C
• 精确质量: 224.035248
• PSA: 44.12000
• LogP: 2.43
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.613

合成路线

541-41-3 55052-24-9 ~69% 849068-50-4

文献：VERTEX PHARMACEUTICALS INCORPORATED Patent: WO2005/28475 A2, 2005 ; Location in patent: Page/Page column 175 ; WO 2005/028475 A2

271-63-6 ~% 849068-50-4

文献：Chowdhury, Sarwat; Sessions, E. Hampton; Pocas, Jennifer R.; Grant, Wayne; Schroeter, Thomas; Lin, Li; Ruiz, Claudia; Cameron, Michael D.; Schuerer, Stephan; Lograsso, Philip; Bannister, Thomas D.; Feng, Yangbo Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7107 - 7112

272-49-1 ~% 849068-50-4

文献：ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta Patent: WO2013/10880 A1, 2013 ;

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