78-28-4

• 常用中文名：依米氨酯
• 常用英文名：emylcamate
• CAS号：78-28-4
• 分子式：C₇H₁₅NO₂
• 分子量：145.19900
• 相关类别： 原料药 神经系统用药 抗焦虑药
• 发布时间：2018-07-29 04:52:20
• 更新时间：2025-08-25 13:47:12
• Emylcamate是一种有效的肌肉松弛剂。Emylcamate在神经系统疾病的研究中具有潜力[1]。

名称

• 中文名: 依米氨酯
• 英文名: 3-methylpentan-3-yl carbamate
• 英文别名: 1-ethyl-1-methylpropyl carbamate; Carbamidsaeure-<1-methyl-1-aethyl-propylester>; Stratran; Emilcamato; Emylcamat; Statran; 3-Carbamoyloxy-3-methyl-pentan; Restetal; Striatran; Emylcamate; Striatan; Nuncital; Psicoplegil

物化性质

• 密度: 0.959g/cm3
• 沸点: 233.3ºC at 760 mmHg
• 熔点: 56-58.5°
• 分子式: C₇H₁₅NO₂
• 分子量: 145.19900
• 闪点: 92.7ºC
• 精确质量: 145.11000
• PSA: 52.32000
• LogP: 2.36070
• 折射率: 1.438

生物活性

• 描述: Emylcamate是一种有效的肌肉松弛剂。Emylcamate在神经系统疾病的研究中具有潜力[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. B. Melander. Emylcamate, A Potent Tranquillizing Relaxant

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : FA9625000 CHEMICAL NAME : Carbamic acid, 1-ethyl-1-methylpropyl ester CAS REGISTRY NUMBER : 78-28-4 BEILSTEIN REFERENCE NO. : 1755436 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C7-H15-N-O2 MOLECULAR WEIGHT : 145.23 WISWESSER LINE NOTATION : ZVOX2&2&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,413,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 760 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,413,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJSAAP Quarterly Journal of Studies on Alcohol. (New Brunswick, NJ) V.1-28, 1940-67. For publisher information, see QJSOAX. Volume(issue)/page/year: 21,223,1960

合成路线

77-74-7 143-33-9 ~% 78-28-4

文献：Loev,B.; Kormendy,M.F. Journal of Organic Chemistry, 1963 , vol. 28, p. 3421 - 3426

77-74-7 463-72-9 ~% 78-28-4

文献：Chininfabr.Zimmer and Co. Patent: DE245491 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 1168

77-74-7 1885-14-9 ~% 78-28-4

文献：Melander Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 443,444

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