373-02-4

• 常用中文名：醋酸镍
• 常用英文名：Nickel-acetic acid (1:1)
• CAS号：373-02-4
• 分子式：C₂H₄NiO₂
• 分子量：118.745
• 相关类别： 有机原料 羧酸类化合物及衍生物 羧酸酯及其衍生物的盐
• 发布时间：2018-05-05 08:00:00
• 更新时间：2024-01-02 14:58:08

• 该物用媒染剂，电镀等。

名称

• 中文名: 醋酸镍
• 英文名: Nickelous acetate
• 中文别名: 乙酸镍(II)盐; 乙酸镍
• 英文别名: anhydrous nickel acetate; Acetic acid, nickel salt (1:1); nickelous diacetate; Nickel diacetate; Nickel - acetic acid (1:1); EINECS 206-761-7

物化性质

• 密度: 9.50 lb/gal
• 沸点: 117.1ºC at 760 mmHg
• 熔点: 1555°C
• 分子式: C₂H₄NiO₂
• 分子量: 118.745
• 闪点: 40ºC
• 精确质量: 117.956474
• PSA: 37.30000
• LogP: 0.09090
• 外观性状: 绿色结晶粉末
• 稳定性:

  浅绿色柱状结晶，具吸湿性。加热至熔点分解，溶于水，在100g水中溶解度为16.6g。不溶于乙醇。有毒，应密闭保存。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积80.3

  7.重原子数量:9

  8.表面电荷:0

  9.复杂度:25.5

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

MSDS

Name: Nickel (II) acetate Material Safety Data Sheet Synonym: Acetic acid, Nickel (II) salt; Nickelous acetat CAS: 373-02-4 Section 1 - Chemical Product MSDS Name:Nickel (II) acetate Material Safety Data Sheet Synonym:Acetic acid, Nickel (II) salt; Nickelous acetat Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 373-02-4 Nickel(ii) acetate 206-761-7 Hazard Symbols: XN Risk Phrases: 20/22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation and if swallowed.Carcinogen. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: May cause respiratory tract irritation. Chronic: May cause cancer according to animal studies. May cause reproductive and fetal effects. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately. Skin: Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. Autoignition Temperature: Not available. Flash Point: Not available. NFPA Rating: Not published. Explosion Limits, Lower: Not available. Upper: Not available. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use with adequate ventilation. Storage: Store in a cool, dry place. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Appearance: green Odor: None reported pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Decomposition Temperature: Not available. Solubility: Soluble in water. Specific Gravity/Density: 1.798 Molecular Formula: C4H6O4Ni Molecular Weight: 176.7296 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: None reported. Incompatibilities with Other Materials: None reported. Hazardous Decomposition Products: Irritating and toxic fumes and gases. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 373-02-4: QR6125000 LD50/LC50: CAS# 373-02-4: Oral, mouse: LD50 = 410 mg/kg; Oral, rat: LD50 = 350 mg/kg. Carcinogenicity: Nickel(ii) acetate - NTP: Suspect carcinogen OSHA: Possible Select carcinogen See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION For further information, contact Fisher Scientific. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION CDG/CPL IMO No information available. IATA No information available. RID/ADR No information available. Canadian TDG No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/22 Harmful by inhalation and if swallowed. Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 373-02-4: Canada CAS# 373-02-4 is listed on Canada's DSL/NDSL List. WHMIS: Not available. CAS# 373-02-4 is listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 373-02-4 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QR6125000 CAS REGISTRY NUMBER : 373-02-4 LAST UPDATED : 199712 DATA ITEMS CITED : 34 MOLECULAR FORMULA : C4-H6-O4.Ni MOLECULAR WEIGHT : 176.81 WISWESSER LINE NOTATION : QV1 &-NI- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 410 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1581 mg/kg/6W-C TOXIC EFFECTS : Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - changes in iron Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25297 mg/kg/4W-C TOXIC EFFECTS : Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15912 ug/kg female 16-18 day(s) after conception TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Endocrine - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 420 mg/kg/47W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95 mg/kg/78W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 360 mg/kg/8W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 225 mg/kg/46W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15912 ug/kg female 17 day(s) after conception TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Endocrine - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 10 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : Unscheduled DNA synthesis MUTATION DATA TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Kidney REFERENCE : IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 53,193,1984 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,264,1987 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,257,1990 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 5,51,1972 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Ni,168,1975 TOXICOLOGY REVIEW ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 3,156,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,178,1971 OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81906 No. of Facilities: 128 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 2489 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81906 No. of Facilities: 481 (estimated) No. of Industries: 18 No. of Occupations: 12 No. of Employees: 6772 (estimated) No. of Female Employees: 281 (estimated)

安全

• 海关编码: 2915299090

合成路线

6018-89-9 ~% 373-02-4

文献：Markgraf, H. Diss. Leipzig 1923, S. 11

1295-35-8 108-05-4 ~0% 54509-73-8 373-02-4

文献：Yamamoto, Takakazu; Ishizu, Junichi; Yamamoto, Akio Journal of the American Chemical Society, 1981 , vol. 103, # 23 p. 6863 - 6869

719261-06-0 64-19-7 ~% 373-02-4

文献：Gmelin Handbook: Ni: MVol.B3, 41, page 859 - 861

108-05-4 15133-82-1 ~41% 54509-73-8 100-40-3 详细

文献：Yamamoto, Takakazu; Ishizu, Junichi; Yamamoto, Akio Journal of the American Chemical Society, 1981 , vol. 103, # 23 p. 6863 - 6869

7664-41-7 6018-89-9 ~% 373-02-4

文献：Gmelin Handbook: Ni: MVol.B3, 41, page 859 - 861

7440-02-0 64-19-7 ~% 373-02-4

文献：Gmelin Handbook: Ni: MVol.AII2, 13, page 934 - 996

481711-38-0 64-19-7 ~% 373-02-4

文献：Guseva; Antina; Berezin Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya, 2003 , vol. 29, # 10 p. 690 - 693

108-24-7 ~% 373-02-4

文献：Spaeth Monatshefte fuer Chemie, vol. 33, p. 246

上下游产品

上游产品  8
6018-89-9 1295-35-8 108-05-4 64-19-7
15133-82-1 108-24-7 7664-41-7 7440-02-0
下游产品  10
3615-17-6 15158-90-4 14266-60-5 1271-28-9
97-61-0 142-62-1 3264-82-2 541-59-3
111-65-9 1313-99-1

制备

制法1 Ni(NO₃)₂·6H₂O+6(CH₃CO)₂O→Ni(CH₃COO)₂+2NO₂+12O₂+10CH₃COOH+H₂O

6g六水硝酸镍加到35mL醋酸酐中，将此混合物加热至开始激烈反应，再煮沸10min。冷却，吸滤至干，用少量乙酸酐洗涤，再用乙醚洗涤。在真空中于80～90℃干燥。

制法2 Ni(CH₃COO)₂·4H₂O+4(CH₃CO) ₂O→Ni(CH₃COO) ₂+8CH₃COOH

将15g四水醋酸镍和150mL醋酸酐加热回流16h，分离出来的结晶用醋酸酐洗涤后抽干，置于盛有氢氧化钠固体的真空干燥器中干燥。

也可用碳酸镍与醋酸反应制取。

海关

海关编码	2915299090
中文概述	HS: 2915299090 其他乙酸盐 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 增值税率:17.0% 最惠国关税:5.5% 普通关税:50.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2915299090 salts of acetic acid。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:50.0%