97747-88-1

• 常用中文名：利洛司酮
• 常用英文名：lilopristone
• CAS号：97747-88-1
• 分子式：C₂₉H₃₇NO₃
• 分子量：447.609
• 发布时间：2018-08-21 19:17:39
• 更新时间：2024-01-14 18:21:42

名称

• 中文名: 利洛司酮
• 英文名: lilopristone
• 中文别名: 磷酸川芎嗪; 盐酸川芎嗪
• 英文别名: Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-3-hydroxy-1-propen-1-yl]-, (11β,17β)-; (8S,11R,13S,14S,17R)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-3-hydroxy-1-propen-1-yl]-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name); Ligustrazine Phosphate; 11b-(p-(Dimethylamino)phenyl)-17b-hydroxy-17-((Z)-3-hydroxypropenyl)estra-4,9-dien-3-one; (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-3-hydroxyprop-1-en-1-yl]estra-4,9-dien-3-one; Ligustrazine Hydrochloride; Ligustrazine HCl

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 658.3±55.0 °C at 760 mmHg
• 分子式: C₂₉H₃₇NO₃
• 分子量: 447.609
• 闪点: 351.9±31.5 °C
• 精确质量: 447.277344
• PSA: 60.77000
• LogP: 4.07
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.628

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG2940000 CHEMICAL NAME : Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(3-hydroxy -1-propenyl)-, (11-beta,17-beta,17(Z))- CAS REGISTRY NUMBER : 97747-88-1 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C29-H37-N-O3 MOLECULAR WEIGHT : 447.67 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1250 ug/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 40,549,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 45 mg/kg SEX/DURATION : female 5-7 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 83,73,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 37500 ug/kg SEX/DURATION : female 24-26 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 38,528,1988